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11.发明公开
公开(公告)号：EP1622906A1
公开(公告)日：2006-02-08
申请号：EP04729415.2
申请日：2004-04-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
IPC分类号： C07D471/08 , A61K31/4995 , A61P13/12
摘要： The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives, tetrahydropyridine derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP1622901A1
公开(公告)日：2006-02-08
申请号：EP04729423.6
申请日：2004-04-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas , SIFFERLEN, Thierry
IPC分类号： C07D451/02 , A61K31/46
CPC分类号： C07D451/02
摘要： The invention relates to novel tropane derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP2029542A2
公开(公告)日：2009-03-04
申请号：EP07735020.5
申请日：2007-03-01
发明人： BEZENCON, Olivier , BUR, Daniel , CORMINBOEUF, Olivier , GRISOSTOMI, Corinna , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
IPC分类号： C07D213/64 , C07D277/34 , C07D401/04 , C07D417/04 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4436 , A61P9/12
CPC分类号： C07D277/34 , C07D213/64 , C07D401/04 , C07D417/04
摘要： The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP1994026A2
公开(公告)日：2008-11-26
申请号：EP07713218.1
申请日：2007-03-07
发明人： BEZENCON, Olivier , BUR, Daniel , CORMINBOEUF, Olivier , GRISOSTOMI, Corinna , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , WELLER, Thomas
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The invention relates to novel amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP1893578A2
公开(公告)日：2008-03-05
申请号：EP06765703.1
申请日：2006-05-23
发明人： BEZENCON, Olivier , BOSS, Christoph , BUR, Daniel , CHEN, Austin, Chih-Yu , CORMINBOEUF, Olivier , DUBE, Daniel , FISCHLI, Walter , GRISOSTOMI, Corinna , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , SIFFERLEN, Thierry , THERIEN, Michel , WELLER, Thomas
IPC分类号： C07D211/78 , C07D471/08 , C07D401/10 , A61K31/451 , C07D401/12 , A61P9/00
CPC分类号： C07D471/08 , C07D211/78 , C07D401/10 , C07D401/12
摘要： The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
摘要翻译： 本发明涉及新的哌啶羧酸酰胺衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及相关方面，包括制备这些新化合物的方法，包含此类化合物的药物组合物，特别是这类化合物作为肾素抑制剂的用途。
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16.发明公开7-{4-[2-(2,6-DICHLORO-4-METHYLPHENOXY)ETHOXY]PHENYL}-3,9-DIAZABICYCLO[3.3.31]NON-6-ENE-6-CARBOXYLIC ACID CYCLOPROPYL-(2,3-DIMETHYLBENZYL)AMIDE AS INHIBITORS OF RENIN FOR THE TREATMENT OF HYPERTENSION. 有权7- {4- [2-（2,6-二氯-4-甲基苯氧基）乙氧基]苯基} -3,9-二氮杂双环[3.3.1]壬-6-烯-6-羧酸环丙基 - （2,3- 甲基苄基）AMID ALS肾素抑制剂用于治疗高血压的治疗
公开(公告)号：EP1846407A1
公开(公告)日：2007-10-24
申请号：EP06710758.1
申请日：2006-01-26
发明人： BEZENCON, Olivier , BUR, Daniel , FISCHLI, Walter , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia , SIFFERLEN, Thierry , WELLER, Thomas
IPC分类号： C07D471/08 , A61K31/504 , A61P9/12
CPC分类号： C07D471/08
摘要： The invention relates to a novel 3,9-diazabicyclα [3.3. ljnonene derivative of formula (I) and the enantiomers thereof and the use thereof as active ingredients in the preparation of pharmaceutical compositions . The invention also concerns related aspects including pharmaceutical compositions containing at least one compound of formula (I) or (I') and especially their use as inhibitors of renin.(I).
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公开(公告)号：EP1786814B1
公开(公告)日：2010-03-31
申请号：EP05777694.0
申请日：2005-08-22
发明人： BEZENCON, Olivier , BOSS, Christoph , BUR, Daniel , CORMINBOEUF, Olivier , FISCHLI, Walter , GRISOSTOMI, Corinna , REMEN, Lubos , RICHARD, Sylvia , SIFFERLEN, Thierry , WELLER, Thomas
IPC分类号： C07D471/08 , A61K31/4995 , A61P13/12 , A61P9/12
CPC分类号： C07D471/08 , C07D513/08
摘要： The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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18.发明公开AZABICYCLOOCTENE AND OTHER TETRAHYDROPYRIDINE DERIVATIVES WITH A NEW SIDE-CHAIN 审中-公开AZABICYCLOOCTEN和一个新的页面链中的其他四氢
公开(公告)号：EP1692132A2
公开(公告)日：2006-08-23
申请号：EP04803362.5
申请日：2004-11-30
发明人： BEZENCON, Olivier , SIFFERLEN, Thierry , BUR, Daniel , FISCHLI, Walter , WELLER, Thomas , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia
IPC分类号： C07D471/08 , A61K31/46 , A61P9/00
摘要： The invention relates to novel bicyclic derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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19.发明公开DIAZABICYCLONONENE AND TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS 审中-公开DIAZABICYCLONONEN- AND四氢吡啶衍生物作为肾素抑制剂
公开(公告)号：EP1680427A1
公开(公告)日：2006-07-19
申请号：EP04765982.6
申请日：2004-10-18
发明人： BEZENCON, Olivier , SIFFERLEN, Thierry , BUR, Daniel , FISCHLI, Walter , WELLER, Thomas , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia
IPC分类号： C07D487/08 , A61K31/4995 , A61P13/12
CPC分类号： C07D513/08 , A01N43/90 , A01N55/00 , C07D471/08 , C07D487/08
摘要： The invention relates to novel bicyclic derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
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公开(公告)号：EP1673341A1
公开(公告)日：2006-06-28
申请号：EP04765809.1
申请日：2004-10-05
发明人： BEZENCON, Olivier , SIFFERLEN, Thierry , BUR, Daniel , FISCHLI, Walter , WELLER, Thomas , REMEN, Lubos , RICHARD-BILDSTEIN, Sylvia
IPC分类号： C07D211/78 , A61K31/451 , A61P9/00
摘要： The invention relates to novel tetrahydropyridine derivatives and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. (I) wherein X and Y represent independently hydrogen, fluorine or a methyl group; X and Y do not represent both hydrogen at the same time or X and Y may together form a cyclopropyl ring; W represents a phenyl or a heteroaryl, the heteroaryl ring being a six-membered and non-fused ring, the phenyl ring and the heteroaryl are substituted with V in position 3 or 4; A and B independently represent -O-;-S-;-SO- or -SO2-; U represents aryl or heteroaryl; T represents -CONR1-;-(CH2)pOCO-; -(CH2)pN(R1)CO-; -(CH2)pN(R1)SO2-; -COO-; -(CH2)pOCONR1 - or -(CH2) pN(R2)CONR1-; R1 and R2 independently respresent hydrogen; lower alkyl; lower alkenyl; lower alkynil; cycloalkyl; aryl-lower alkyl, heteroaryl-lower alkyl or cycloalkyl - lower alkyl; Q represents lower alkylene or lower alkenylene; M represents hydrogen; cycloalkyl; aryl; heterocyclyl or heteroaryl:
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