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    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    11.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    方法和组合物诊断和预后判断肾功能衰竭和肾损害

    公开(公告)号：EP3153863A1

    公开(公告)日：2017-04-12

    申请号：EP16196505.8

    申请日：2010-11-05

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James Patrick

    IPC分类号： G01N33/68

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect soluble Transmembrane glycoprotein NMB, and optionally further a kidney injury marker of C-C motif chemokine 23, Brain-derived neurotrophic factor, Cathepsin S, Transforming growth factor beta-2, Urokinase-type plasminogen activator, Angiopoietin-2, Matrilysin, Carcinoembryonic antigen-related cell adhesion molecule 1, Creatine kinase MB, Insulin, Immunoglobulin M, Immunoglobulin E, Macrophage migration inhibitory factor, Galectin-3, Transforming growth factor beta-3, Heparan sulfate, soluble Cadherin-3, Complement C5, Platelet factor 4, Platelet basic protein, and Stromelysin-2 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及一种使用经配置以检测可溶性跨膜糖蛋白NMB一个一种或多种测定，并且任选地进一步肾损伤标记物CC基序趋化因子23，脑源性神经营养因子，组织蛋白酶S的，转化生长因子β-2， 尿激酶型纤维蛋白溶酶原活化剂，血管生成素-2，基质溶素，癌胚抗原相关细胞粘附分子1，肌酸激酶MB，胰岛素，免疫球蛋白男，免疫球蛋白E，巨噬细胞迁移抑制因子，半乳糖凝集素-3，转化生长因子β-3，类肝素 硫酸盐，可溶性钙粘蛋白3，补体C5，血小板因子4，血小板碱性蛋白，和溶基质蛋白酶-2在肾损伤作为诊断和预后标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    13.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2820146A1

    公开(公告)日：2015-01-07

    申请号：EP13755796.3

    申请日：2013-02-27

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： C12Q1/00 ,  G01N33/50 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  A61M1/1601 ,  A61M2202/0413 ,  A61M2205/75 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of SPARC, Follistatin-related protein 1, Tumor necrosis factor receptor superfamily member 21, Growth arrest-specific protein 1, MHC class I polypeptide-related sequence A, Syndecan-1, and WNTl-inducible-signaling pathway protein 1 as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用一种或多种配置成检测选自SPARC，Follistatin相关蛋白1，肿瘤坏死因子受体超家族成员21，生长停滞特异性蛋白1，MHC I类多肽相关序列A，Syndecan-1和WNT1诱导型信号传导通路蛋白1作为肾损伤中的诊断和预后生物标志物。

    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
    17.
    发明公开
    METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
    肾损伤和肾功能衰竭的诊断和预后的方法和组合物

    公开(公告)号：EP2480882A1

    公开(公告)日：2012-08-01

    申请号：EP10818036.5

    申请日：2010-09-21

    申请人： Astute Medical, Inc.

    发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

    IPC分类号： G01N33/48 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

    摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of metalloproteinase inhibitor 2, soluble oxidized low-density lipoprotein receptor 1, interleukin-2, von Willebrand factor, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor receptor superfamily member 11B, neutrophil elastase, interleukin-1 beta, heart-type fatty acid-binding protein, beta-2-glycoprotein 1, soluble CD40 ligand, coagulation factor VII, C—C motif chemokine 2, IgM, CA 19-9, IL-10, TNF-α, and myoglobin as diagnostic and prognostic biomarkers in renal injuries.

    摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用多种测定法，其中一种或多种测定法被配置为检测选自由金属蛋白酶抑制剂2，可溶性氧化低密度脂蛋白受体1，白细胞介素-2，von Willebrand因子，粒细胞 - 巨噬细胞集落刺激因子，肿瘤坏死因子受体超家族成员11B，嗜中性粒细胞弹性蛋白酶，白细胞介素-1β，心型脂肪酸结合蛋白，β-2-糖蛋白1，可溶性CD40配体，凝血因子VII ，C-motif趋化因子2，IgM，CA 19-9，IL-10，TNF-α和肌红蛋白作为肾损伤中的诊断和预后生物标志物。