公开(公告)号：EP1092035A2

公开(公告)日：2001-04-18

申请号：EP99932760.4

申请日：1999-06-30

申请人： Austrian Nordic Biotherapeutics AG

发明人： GÜNZBURG, Walter ,  SALMONS, Brian ,  GOLLER, Sabine ,  KLEIN, Dieter

IPC分类号： C12N15/86 ,  C12N5/10 ,  A61K48/00

CPC分类号： C12N15/86 ,  C12N2740/13043

摘要： To achieve the foregoing and other objects, the present invention provides a retroviral vector comprising in its LTRs sequences, preferably sequences of an adeno-associated virus, for a targeted integration.

公开(公告)号：EP1115879A1

公开(公告)日：2001-07-18

申请号：EP99950543.1

申请日：1999-09-23

申请人： Austrian Nordic Biotherapeutics AG

发明人： GÜNZBURG, Walter ,  SALMONS, Brian ,  BAUMANN, Jörg

IPC分类号： C12N15/86 ,  C12N15/12 ,  C12N15/48 ,  C12N5/10 ,  C12N7/01 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K35/12 ,  A61K48/00 ,  C12N15/86 ,  C12N2740/13052

摘要： The present invention relates to retroviral particles which are specifically applicable as safe gene transfer vehicles for targeted gene therapy and which are protected against complement mediated destruction in host organisms. For producing such retroviral particles a packaging cell is provided according to the present invention comprising a DNA construct coding for one or more complement inhibitors. Said inhibitors are derived from the complement system of the organism to be infected by the retroviral particle generated by the packaging cell.