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11.发明公开SUBSTITUIERTE ISOINDOLONE UND IHRE VERWENDUNG ALS CYCLISCHE GMP MODULATOREN IN ARZNEIMITTELN 有权取代的异吲哚酮及其作为cGMP的调节剂药品
公开(公告)号：EP1064262A1
公开(公告)日：2001-01-03
申请号：EP99907548.4
申请日：1999-02-12
IPC分类号： C07D209/48 , A61K31/40 , C07D401/04 , C07D409/04
CPC分类号： C07D209/48 , C07D401/04 , C07D409/04
摘要： The invention relates to substituted isoindolon derivatives of formula (I), wherein R?1, R2, R3, R4, R5, R6 and R7¿ have the meanings cited in the description. Said derivatives represent valuable active substances in medicaments for the therapy and prophylaxis of diseases, e.g. cardiovascular diseases such a hypertension, angina pectoris, heart failures, thrombosis or atherosclerosis. The compounds of formula (I) are capable of modulating endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of pathological states associated with disorders of the cGMP metabolism. The invention also relates to a method for the production of compounds of formula (I), their use in the therapy and prophylaxis of the above-mentioned pathological states and in the production of medicaments for such states. The invention further relates to pharmaceutical preparations containing the compounds of formula (I).
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