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11.发明授权Modified live pseudorabies viruses, vaccines for pseudorabies disease containing same, methods for production of same and methods for use of same 失效修饰的活体染色体病毒，含有其的PSEUDORABIES疾病的疫苗，其生产方法和使用它们的方法
公开(公告)号：EP0149040B1
公开(公告)日：1993-06-09
申请号：EP84113424.0
申请日：1984-11-07
发明人： Kit, Malon , Kit, Saul
IPC分类号： A61K39/245 , C12N7/04 , C12N15/38
CPC分类号： C12N15/00 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N2710/16734 , Y10S424/822
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12.发明授权Thymidine kinase deletion mutants of bovine herpesvirus-1, vaccines against infectious bovine rhinotracheitis containing same and methods for the production and use of the same 失效牛血清白蛋白脱乙酰壳多糖脱氧核糖核酸酶，含有其的感染性牛血清白蛋白的疫苗及其生产和使用方法
公开(公告)号：EP0226029B1
公开(公告)日：1992-03-11
申请号：EP86115455.7
申请日：1986-11-07
发明人： Kit, Malon , Kit, Saul
IPC分类号： A61K39/265
CPC分类号： C12N15/00 , A61K39/12 , A61K39/245 , C12N2710/16734 , Y10S424/813 , Y10S424/822 , Y10S930/224
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13.发明公开Infectious bovine rhinotracheitis virus insertion mutants, vaccins containing same, and methods for the production and use of same 失效感染性牛血清病毒载体突变体，含有疫苗的疫苗及其生产和使用方法
公开(公告)号：EP0326127A3
公开(公告)日：1990-03-28
申请号：EP89101338.5
申请日：1989-01-26
发明人： Kit, Malon , Kit, Saul , Otsuka, Haruki
IPC分类号： C12N7/04 , A61K39/265 , C12N15/00
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/265 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N15/00 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743
摘要： The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against infectious bovine rhinotracheitis containing the same and methods for production and use of same. The present invention also relates to infectious bovine rhinotracheitis-based viral vectors useful for the coexpression of foreign genes.
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14.发明公开Infectious bovine rhinotracheitis virus insertion mutants, vaccins containing same, and methods for the production and use of same 失效传染性牛鼻气管炎病毒插入突变体，含有它们的疫苗，其制备方法和它们的用途。
公开(公告)号：EP0326127A2
公开(公告)日：1989-08-02
申请号：EP89101338.5
申请日：1989-01-26
发明人： Kit, Malon , Kit, Saul , Otsuka, Haruki
IPC分类号： C12N7/04 , A61K39/265 , C12N15/00
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/265 , A61K2039/5254 , A61K2039/552 , C07K14/005 , C12N15/00 , C12N2710/16722 , C12N2710/16734 , C12N2710/16743
摘要： The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against infectious bovine rhinotracheitis containing the same and methods for production and use of same. The present invention also relates to infectious bovine rhinotracheitis-based viral vectors useful for the coexpression of foreign genes.
摘要翻译： 本发明涉及感染性牛鼻气管炎病毒哪不能产生任何功能胸苷激酶如胸苷激酶基因中的插入的结果，针对感染性牛鼻气管炎疫苗包含用于生产和使用的相同的相同和方法。 因此，本发明涉及用于外源基因的共表达是有用的传染性牛鼻气管炎基于病毒载体。
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15.发明公开Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same 失效PSEUDORABIES VIRUS MUTANTS，VACCINES含有它们的疫苗，其生产方法和使用它们的方法
公开(公告)号：EP0232798A3
公开(公告)日：1987-10-14
申请号：EP87101134
申请日：1987-01-28
发明人： Kit, Malon , Kit, Saul
IPC分类号： C12N15/00 , C12N07/00 , A61K39/245
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/245 , C12N15/00 , C12N2710/16722 , C12N2710/16734
摘要： The present invention relates to pseudorabies virus mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced. As a re- sutt. animals vaccinated with such do not develop antibodies to the viral glycoprotein and can be distinguished from animals infected with pseudorabies virus field strains and known pseudorabies virus vaccine strains. The present invention also relates to vaccines for pseudorabies disease containing the same, methods for production of the same and methods for use of the same.
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16.发明公开Modified live pseudorabies viruses, vaccines for pseudorabies disease containing same, methods for production of same and methods for use of same 失效改良的活体染色体病毒，含有其的PSEUDORABIES疾病的疫苗，其生产方法和使用它们的方法
公开(公告)号：EP0149040A3
公开(公告)日：1986-06-11
申请号：EP84113424
申请日：1984-11-07
发明人： Kit, Malon , Kit, Saul
IPC分类号： A61K39/245 , C12N07/04 , C12N15/00
CPC分类号： C12N15/00 , A61K39/12 , A61K39/245 , A61K2039/5254 , C12N2710/16734 , Y10S424/822
摘要： Temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of mutagen-induced mutation and temperature-resistant pseudorabies viruses which fail to produce any functional TK as a result of a deletion in the tk gene, vaccines containing same, methods for production of same and methods for use of same.
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17.发明公开Thymidine kinase-negative temperature resistant bovine herpesvirus-1 mutant as a vaccine against infectious bovine rhinotracheitis 失效甲胺激酶阴性耐药猪Hervirus-1突变体作为一种疫苗对抗感染性牛血清白蛋白
公开(公告)号：EP0119025A3
公开(公告)日：1986-03-26
申请号：EP84301158
申请日：1984-02-23
发明人： Kit, Saul
IPC分类号： A61K39/245 , A61K39/265 , C12N05/00
CPC分类号： A61K39/265 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2710/16734
摘要： Described are thymidine kinase negative temperature resistant mutants of bovine herpesvirus effective in inducing resistance to infectious bovine rhinotracheitis, methods for their production, methods for maintaining them in viable form, and methods for administering them to animals in immunologically effective doses to induce reistance to infectious bovine rhinotracheitis.
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