公开(公告)号：EP4416133A1

公开(公告)日：2024-08-21

申请号：EP22801308.2

申请日：2022-10-11

申请人： Baylor College of Medicine

发明人： YOUNG, Damian Winston ,  CHAMAKURI, Srinivas ,  SANTINI, Conrad ,  MATZUK, Martin M. ,  TRAN, Kevin A. ,  JAIN, Prashi ,  GUDURU, Shiva Krishna Reddy ,  RAJI, Idris O. ,  SAMUEL, Errol L.G. ,  MACKENZIE, Kevin R.

IPC分类号： C07D241/04 ,  A61K31/495 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00

CPC分类号： C07D241/04 ,  A61P3/00 ,  A61P25/00 ,  A61P35/00 ,  A61P11/00 ,  A61P13/00 ,  A61P31/00 ,  A61P29/00 ,  A61P9/00

公开(公告)号：EP4380959A1

公开(公告)日：2024-06-12

申请号：EP22854080.3

申请日：2022-08-03

申请人： Baylor College of Medicine

发明人： ROSENGART, Todd ,  PINNAMANENI, Jayapratap ,  SINGH, Vivek P. ,  YANG, Jiangchang

IPC分类号： C07K14/47 ,  A61K38/00 ,  C12N15/79 ,  A61P35/00 ,  A61P9/00

CPC分类号： A61P9/00 ,  A61P35/00 ,  C07K14/475 ,  C12N2740/1604320130101 ,  C12N2710/1034320130101 ,  A61K38/1758

公开(公告)号：EP4290238A2

公开(公告)日：2023-12-13

申请号：EP23205747.1

申请日：2016-09-19

申请人： Baylor College of Medicine

发明人： LEEN, Ann, Marie ,  AGUAYO-HIRALDO, Pailbel ,  TZANNOU, Ifigeneia ,  VERA, Juan, F., Valdes

IPC分类号： G01N33/569

摘要： Embodiments of the disclosure concern methods of identifying whether or not antigens from a particular pathogen are immunogenic, including the order of their immunogenicity. Other embodiments concern correlations between attributes of T cells and their clinical efficacy, such as mathematical representations thereof.

公开(公告)号：EP4254045A2

公开(公告)日：2023-10-04

申请号：EP23192572.8

申请日：2017-04-13

申请人： Baylor College of Medicine ,  Texas Heart Institute

发明人： BURT, Bryan, M. ,  KHAN, Mahmood ,  COHN, William

IPC分类号： G02B27/00

摘要： One aspect of the invention provides a trocar, comprising: a central cylinder defining a central channel and having a distal end configured for insertion within a body cavity of a subject; one or more outlets located within the central cylinder, wherein the one or more outlets are configured to dispense a liquid when an endoscope is withdrawn from a distally extended position within the central channel of the trocar to a position proximate to the one or more outlets, the one or more outlets having a shape or size sufficient to generate sufficient flow to reach a center of the central cylinder and clean a lens of the endoscope; a sensor configured to detect when a distal end of the endoscope has been withdrawn to the position proximate to the one or more outlets; and a controller in communication with the sensor, the controller configured to control the flow to the one or more outlets to expel the liquid from the one or more outlets when the distal end of the endoscope is proximate to the one or more outlets.

公开(公告)号：EP4238573A1

公开(公告)日：2023-09-06

申请号：EP23168971.2

申请日：2017-04-15

申请人： Baylor College of Medicine

发明人： COSTA-MATTIOLI, Mauro ,  BUFFINGTON, Shelly Alexandra

IPC分类号： A61K35/74 ,  A61P25/00 ,  A61P25/20 ,  A61P25/28

摘要： Embodiments of the disclosure concern methods and compositions related to manipulation of the microbiome in an individual having at least one social behavior deficit. In particular embodiments, an individual has at least one social behavior deficit and was born from a mother who during pregnancy was obese, overweight, or on a high-fat diet during pregnancy or carries mutations associated with neurodevelopmental disorders. In specific embodiments, the individual having at least one social behavior deficit is provided an effective amount of Lactobacillus reuteri for the improvement of at least one symptom of a social behavior deficit.

公开(公告)号：EP4221566A1

公开(公告)日：2023-08-09

申请号：EP21876687.1

申请日：2021-09-27

申请人： Baylor College of Medicine

发明人： SOLYMAN, Omar

IPC分类号： A61B3/10 ,  A61B3/12 ,  A61B3/13 ,  A61B3/14 ,  H04N13/10 ,  H04N13/189 ,  A61B3/18 ,  H04N13/239

公开(公告)号：EP4185213A1

公开(公告)日：2023-05-31

申请号：EP21847000.3

申请日：2021-07-21

申请人： Baylor College Of Medicine ,  Texas Children's Hospital

发明人： STAROSOLSKI, Zbigniew ,  ADMANE, Prasad ,  DUNN, James ,  KAZINY, Brent ,  ANNAPRAGADA, Ananth

IPC分类号： A61B10/00 ,  A61B10/02 ,  C12Q1/68 ,  C12Q1/6806

公开(公告)号：EP4142750A1

公开(公告)日：2023-03-08

申请号：EP21729195.4

申请日：2021-04-27

申请人： Baylor College of Medicine

发明人： QUACH, David H. ,  ROONEY, Cliona M. ,  RAMOS, Carlos A.

IPC分类号： A61K35/17 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C07K14/705

公开(公告)号：EP4142747A1

公开(公告)日：2023-03-08

申请号：EP21725957.1

申请日：2021-04-27

申请人： Baylor College of Medicine

发明人： QUACH, David H. ,  ROONEY, Cliona M. ,  RAMOS, Carlos A.

IPC分类号： A61K35/17 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C07K14/705

公开(公告)号：EP4082538A1

公开(公告)日：2022-11-02

申请号：EP22166195.2

申请日：2014-07-18

申请人： Baylor College of Medicine

发明人： TWEARDY, David ,  KASEMBELI, Moses ,  XU, Marvin ,  ECKOLS, Thomas

IPC分类号： A61K31/18 ,  A61K31/4196 ,  A61K45/06 ,  A61P21/00 ,  A61P21/06

摘要： Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.