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公开(公告)号：EP1771453B1
公开(公告)日：2012-05-30
申请号：EP05763539.3
申请日：2005-07-15
发明人： BAILEY, Murray, D. , BHARDWAJ, Punit , GHIRO, Elise , GOUDREAU, Nathalie , HALMOS, Teddy , LLINAS-BRUNET, Montse , POUPART, Marc-André , RANCOURT, Jean
IPC分类号： C07D491/048 , C07D413/04 , C07D405/14 , C07D401/12 , C07D413/12 , C07D417/14 , C07D471/04 , C07D207/16 , A61P31/14 , A61K31/40 , A61K31/47 , A61K31/5377 , C07D207/48
CPC分类号： C07D413/04 , A61K38/00 , C07K5/06139 , C07K5/06191
摘要： The present invention relates to compounds of formula (I): wherein R1, R2, R4, n and m are as defined herein and R3 is selected from: (i) -C(O)OR31 wherein R31 is (C1-6)alkyl or aryl, wherein the (C1-6)alkyl is optionally substituted with one to three halogen substituents; (ii) -C(O)NR32R33, wherein R32 and R33 are each independently selected form H, (C1-6)alkyl, and Het; (iii) -SOvR34, wherein v is 1 or 2 and R34 is selected from: (C1-6)alkyl, aryl, Het, and NR32R33 wherein R32 and R33 are as defined above; and (iv) -CO(O)-R35, wherein R35 is selected from (C1-8)alkyl, (C3-7)cycloalkyl-(C1-4)alkyl, aryl, aryl-(C1-6)alkyl, Het and Het-(C1-6)alkyl, each of which are optionally substituted with one or more substituents each independently selected from halo, (C1-6)alkyl, (C3-7)cycloalkyl, aryl, Het, hydroxyl, -O-(C1-6)alkyl, -S-(C1-6)alkyl, -SO-(C1-6)alkyl, -SO2-(C1-6)alkyl, -O-aryl, -S-aryl, -SO-aryl and -SO2-aryl, wherein the aryl portion of the -O-aryl, -S-aryl, -SO-aryl and -SO2-aryl are each optionally substituted with one to five halo substituents. The present invention further relates to pharmaceutical compositions containing the compounds of formula (I) and methods for using these analogs in the treatment of HCV infection.
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公开(公告)号：EP2417140A1
公开(公告)日：2012-02-15
申请号：EP10761139.4
申请日：2010-04-07
发明人： STURINO, Claudio , DEROY, Patrick , DUPLESSIS, Martin , EDWARDS, Paul J. , FAUCHER, Anne-Marie , HALMOS, Teddy , JAMES, Clint , LACOSTE, Jean-Eric , MALENFANT, Eric , MINVILLE, Joannie , MORENCY, Louis , MORIN, Sebastien , TREMBLAY, Martin , YOAKIM, Christiane
IPC分类号： C07D491/048 , A61K31/519 , A61K31/549 , A61P31/18 , C07D487/04 , C07D491/147 , C07D513/04
CPC分类号： C07D491/048 , C07D487/04 , C07D491/147 , C07D513/04 , C07D519/00
摘要： Compounds of formula (I): wherein R
1 , R
2 , A
1 , A
2 , A
3 , A
4 , X and Y are as defined herein, are useful as inhibitors of HIV replication.摘要翻译： 式（I）化合物：其中R 1，R 2，A 1，A 2，A 3，A 4，X和Y如本文所定义，可用作HIV复制的抑制剂。
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公开(公告)号：EP2220076B1
公开(公告)日：2012-01-18
申请号：EP08848765.7
申请日：2008-11-03
发明人： TSANTRIZOS, Youla S. , BAILEY, Murray D. , BILODEAU, François , CARSON, Rebekah J. , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , SIMONEAU, Bruno
IPC分类号： C07D413/04 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D215/02 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/06
CPC分类号： C07D413/14 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds of formula I : wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
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公开(公告)号：EP1771454B1
公开(公告)日：2011-06-15
申请号：EP05768319.5
申请日：2005-07-18
发明人： BAILEY, Murray, D. , BHARDWAJ, Punit , GHIRO, Elise , GOUDREAU, Nathalie , HALMOS, Teddy , LLINAS-BRUNET, Montse , POUPART, Marc-André , RANCOURT, Jean
IPC分类号： C07D495/04 , C07D401/04 , C07D401/12 , A61P31/14 , A61K31/40 , A61K31/47 , C07D413/12 , C07D417/12 , C07D417/04 , C07D413/04
CPC分类号： C07D401/04 , A61K38/00 , C07D401/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07K5/0205
摘要： The invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infection in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compounds of the formula (III) which can be reacted with an amide anion to produce the compounds of formula (I).
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公开(公告)号：EP1763531A1
公开(公告)日：2007-03-21
申请号：EP05759498.8
申请日：2005-06-22
发明人： BAILEY, Murray, D. , BHARDWAJ, Punit , FORGIONE, Pasquale , GHIRO, Elise , GOUDREAU, Nathalie , HALMOS, Teddy , LLINAS-BRUNET, Montse , POUPART, Marc-André , RANCOURT, Jean
IPC分类号： C07D495/04 , C07D413/04 , C07D207/16 , C07D403/12 , A61P31/14 , A61K31/422 , A61K31/4353 , A61K31/47 , A61K31/495 , A61K31/40 , C07D413/12 , C07D215/22 , C07D215/227
CPC分类号： C07D413/04 , C07D207/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/04 , C07D495/04 , C07D498/04 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C07K5/0827
摘要： The invention relates to compounds of formula (I) wherein R', R2, R3, R4, R5, R6, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infections in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compounds of the formula (III) which can be reacted with an amide anion to produce the compounds of formula (I).
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公开(公告)号：EP1673385A1
公开(公告)日：2006-06-28
申请号：EP04761821.0
申请日：2004-09-20
发明人： LLINAS-BRUNET, Montse , BAILEY, Murray , BHARDWAJ, Punit , FORGIONE, Pasquale , GHIRO, Elise , GOUDREAU, Nathalie , HALMOS, Teddy , RANCOURT, Jean
CPC分类号： C07K5/0827 , A61K38/00 , C07K5/0802 , C07K5/0812 , Y02A50/463
摘要： Compounds of formula I: wherein D, R4, R3, L0, L1, L2, R2 and RC are defined herein; or a pharmaceutically acceptable salt thereof, useful as inhibitors of the HCV NS3 protease.
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