公开(公告)号：EP4067369B1

公开(公告)日：2024-05-22

申请号：EP19945395.2

申请日：2019-11-29

IPC: C07K7/04 ,  G01N33/68 ,  G01N33/574

CPC classification number: G01N33/574 ,  G01N33/54386 ,  G01N33/54387 ,  C07K5/0806 ,  C07K5/0812

公开(公告)号：EP4357342A1

公开(公告)日：2024-04-24

申请号：EP22866556.8

申请日：2022-09-05

Applicant: Guangdong Raynovent Biotech Co., Ltd.

Inventor： CHEN, Xiaoxin ,  WANG, Jingjing ,  HUANG, Jianzhou ,  LIU, Zhuowei ,  LONG, Chaofeng ,  CHEN, Shuhui ,  CHEN, Kevin X

IPC: C07D413/12 ,  C07D207/27 ,  A61K31/4015 ,  A61P31/00

CPC classification number: A61K31/4015 ,  A61K31/427 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/513 ,  A61K31/635 ,  A61K38/06 ,  A61P31/00 ,  A61P31/14 ,  C07D207/27 ,  C07D413/12 ,  C07K5/0804 ,  C07K5/0812

Abstract: A class of ketoamide derivatives and an application thereof are disclosed. Specifically disclosed are a compound of formula (IV) and a pharmaceutically acceptable salt thereof.

公开(公告)号：EP3368544A1

公开(公告)日：2018-09-05

申请号：EP16785469.4

申请日：2016-10-24

Applicant: F. Hoffmann-La Roche AG

Inventor： ALANINE, Alexander ,  BEIGNET, Julien ,  BLEICHER, Konrad ,  FASCHING, Bernhard ,  HILPERT, Hans ,  HU, Taishan ,  MACDONALD, Dwight ,  JACKSON, Stephen ,  KOLCZEWSKI, Sabine ,  KROLL, Carsten ,  SCHAEUBLIN, Adrian ,  SHEN, Hong ,  STOLL, Theodor ,  THOMAS, Helmut ,  WAHHAB, Amal ,  ZAMPALONI, Claudia

IPC: C07K5/02 ,  A61P31/04 ,  A61K38/00

CPC classification number: C07K5/0827 ,  A61K38/00 ,  C07K5/02 ,  C07K5/06086 ,  C07K5/08 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/081 ,  C07K5/0812 ,  C07K5/0815 ,  C07K5/0821

Abstract: The present invention provides compounds of formula (I) wherein X1 to X8 and R1 to R8 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.

公开(公告)号：EP3352775A1

公开(公告)日：2018-08-01

申请号：EP16775555.2

申请日：2016-09-21

Applicant: Assistance Publique - Hôpitaux de Paris ,  Université Paris Descartes ,  Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Centre National de la Recherche Scientifique

Inventor： WOLF, Jean-Philippe ,  LOMBÈS, Anne ,  BOMSEL, Morgane

IPC: A61K38/12 ,  C07K14/705 ,  C07K5/12 ,  C07K7/64 ,  A61P15/08 ,  A61K8/64

CPC classification number: A61K38/12 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/0048 ,  A61P15/08 ,  B63B21/00 ,  B63B2021/004 ,  C07K5/0812 ,  C07K7/64 ,  C07K14/705

Abstract: The present invention relates to the use of a cyclic peptide comprising the tripeptide reproducing a binding site of fertilin beta to the oocyte integrin, for improving cellular energy metabolism. More particularly, the invention concerns the use of a cyclic peptide comprising the tripeptide FEEc for stimulating the energy metabolism of gametes or embryonic cells in the context of medically assisted procreation (MAP) protocols, in particular promoting the in vitro maturation of the oocyte, the fertilisation rate and the birth rate.

公开(公告)号：EP2612856B1

公开(公告)日：2018-07-18

申请号：EP12197779.7

申请日：2008-10-03

Applicant: Onyx Therapeutics, Inc.

Inventor： Phiasivongsa, Pasit ,  Sehl, Louis C. ,  Fuller, William Dean ,  Laidig, Guy J.

IPC: A61P19/08 ,  A61P25/28 ,  A61P31/00 ,  A61P33/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  C07D303/36 ,  C07D301/03 ,  C07K5/087

CPC classification number: C07K5/1016 ,  A61K38/00 ,  C07C51/412 ,  C07C53/18 ,  C07D301/00 ,  C07D301/03 ,  C07D303/36 ,  C07K1/1075 ,  C07K1/306 ,  C07K5/0812 ,  C07K5/1008

Abstract: The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.

公开(公告)号：EP3133073B1

公开(公告)日：2018-05-02

申请号：EP16189661.8

申请日：2013-01-03

Applicant: Curis, Inc. ,  GENENTECH, INC.

Inventor： COHEN, Frederick ,  FLYGARE, John A. ,  GAZZARD, Lewis J. ,  TSUI, Vickie Hsiao-Wei

IPC: C07D417/14

CPC classification number: A61K38/06 ,  A61K38/00 ,  A61K45/06 ,  C07K5/08 ,  C07K5/0804 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0815

Abstract: Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: wherein R 1 ,R 2 ,R 3 ,R 4 ,R 5 and R 6 are as described herein.

公开(公告)号：EP3204402A1

公开(公告)日：2017-08-16

申请号：EP15784441.6

申请日：2015-10-09

Applicant: University of Strathclyde

Inventor： ULIJN, Rein ,  TUTTLE, Tell ,  FREDERIX, Pim ,  SCOTT, Gary ,  ABUL-HAIJA, Yousef

IPC: C07K5/09 ,  C07K5/087 ,  B82Y40/00 ,  G06F19/16

CPC classification number: A61K38/06 ,  A61K9/0014 ,  A61K47/48784 ,  A61L15/60 ,  B82Y40/00 ,  C07K5/0812 ,  C07K5/0815 ,  G06F19/16

Abstract: The present invention relates to a method of predicting the propensity of tripeptides to from aggregates in solution. The present invention also provides tripeptides which are able to form aggregates in solution, as well as uses thereof. The present invention also provides nanostructures formed by self-aggregation of tripeptides of the present invention. The present invention also provides pH responsive aggregates as well as methods of screening for the ability of a tripeptide to form a pH dependent aggregate or gel.

Abstract translation: 本发明涉及预测溶液中三肽从聚集体倾向的方法。 本发明还提供了能够在溶液中形成聚集体的三肽及其用途。 本发明还提供了通过本发明三肽的自聚集形成的纳米结构。 本发明还提供了pH响应性聚集体以及筛选三肽形成pH依赖性聚集体或凝胶的能力的方法。

公开(公告)号：EP2457893B1

公开(公告)日：2017-08-16

申请号：EP11009050.3

申请日：2005-06-13

Applicant: Ocera Therapeutics, Inc.

Inventor： Hoveyda, Hamid ,  Peterson, Mark L. ,  Fraser, Graeme ,  Ramaseshan, Mahesh

IPC: C07C271/16 ,  C07C271/20 ,  C07D213/64

CPC classification number: C07K5/0827 ,  A61K38/00 ,  C07D273/00 ,  C07D498/08 ,  C07K5/0808 ,  C07K5/0812

公开(公告)号：EP3160984A1

公开(公告)日：2017-05-03

申请号：EP15738001.5

申请日：2015-06-24

Applicant: Flamma S.P.A.

Inventor： ZHAO, Xinjun ,  ZHENG, Minyu ,  YU, Xiaozhong ,  GAO, Hanrong ,  CORNILLE, Fabrice

IPC: C07K5/11 ,  C07K5/068 ,  C07K5/087

CPC classification number: C07K5/1019 ,  C07K5/06034 ,  C07K5/06086 ,  C07K5/0812

Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.

Abstract translation: 本发明涉及D-精氨酰-2,6-二甲基-L-酪氨酰-L-赖氨酰-L-苯丙氨酰胺的溶液相合成方法，该活性成分用于常见和罕见疾病，包括线粒体靶向治疗 缺血再灌注损伤。

公开(公告)号：EP3127913A1

公开(公告)日：2017-02-08

申请号：EP15002304.2

申请日：2015-08-03

Applicant: Ruprecht-Karls-Universität Heidelberg

Inventor： Krämer, Roland ,  Arian, Dumitru ,  Harenberg, Job

IPC: C07K5/087 ,  C07K5/09 ,  G01N33/68

CPC classification number: C07K5/0812 ,  C07K5/06026 ,  C07K5/06165 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0815 ,  C07K5/0817 ,  C07K5/0819 ,  C07K5/0823 ,  C07K5/1008 ,  C07K5/101 ,  C12Q1/37

Abstract: The present invention relates to chromogenic and fluorogenic substrates that can be used for the highly sensitive and selective detection of the activity of serine proteases. The present invention further relates to methods for the detection of the activity of serine proteases, said methods using the substrates of the present invention. Furthermore, the present invention relates to diagnostic kits and test strips using the above substrates, as well as uses of said substrates.

Abstract translation: 本发明涉及可用于高灵敏度和选择性检测丝氨酸蛋白酶活性的显色和荧光底物。 本发明还涉及用于检测丝氨酸蛋白酶活性的方法，所述方法使用本发明的底物。 此外，本发明涉及使用上述底物的诊断试剂盒和测试条以及所述基底的用途。