公开(公告)号：EP4437972A2

公开(公告)日：2024-10-02

申请号：EP24178269.7

申请日：2014-12-12

申请人： Case Western Reserve University

发明人： MARKOWITZ, Sanford ,  CHAK, Amitabh ,  WILLIS, Joseph ,  TAGGART, Jeffrey Silver ,  BLICE, Rebecca ,  SECREST, Dean ,  SIEDLAK, Dennis

IPC分类号： A61B10/02

CPC分类号： A61B2010/021620130101 ,  A61B10/02 ,  A61B2010/022520130101

摘要： A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：EP4157097A1

公开(公告)日：2023-04-05

申请号：EP21734601.4

申请日：2021-05-26

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： MARKOWITZ, Sanford ,  CHAK, Amitabh ,  WILLIS, Joseph ,  AKLOG, Lishan ,  YAZBECK, Richard ,  BOUTILLETTE, Michael ,  DEGUZMAN, Brian ,  WURTMAN, David

IPC分类号： A61B10/00 ,  A61B10/02

公开(公告)号：EP4106748A1

公开(公告)日：2022-12-28

申请号：EP21756279.2

申请日：2021-02-22

申请人： CASE WESTERN RESERVE UNIVERSITY ,  Inje Industry Academic Cooperation Foundation

发明人： MARKOWITZ, Sanford ,  BAE, KiBeom ,  KIM, Hye Jung ,  KIM, Sun-Hee

IPC分类号： A61K31/395 ,  A61K31/4365 ,  A61P13/12

公开(公告)号：EP3622894A1

公开(公告)日：2020-03-18

申请号：EP19208108.1

申请日：2014-12-12

申请人： Case Western Reserve University

发明人： MARKOWITZ, Sanford ,  CHAK, Amitabh ,  WILLIS, Joseph ,  TAGGART, Jeffrey Silver ,  BLICE, Rebecca ,  SECREST, Dean ,  SIEDLAK, Dennis

IPC分类号： A61B10/02

摘要： A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：EP4278012A1

公开(公告)日：2023-11-22

申请号：EP22740108.0

申请日：2022-01-14

申请人： CASE WESTERN RESERVE UNIVERSITY ,  The Johns Hopkins University

发明人： MARKOWITZ, Sanford ,  CHAK, Amitabh ,  WILLIS, Joseph ,  MOINOVA, Helen ,  VOGELSTEIN, Bert ,  KINZLER, Kenneth ,  PAPADOPOULOS, Nickolas ,  BETTEWGOWDA, Chetan ,  DOUVILLE, Christopher

IPC分类号： C12Q1/6883 ,  C12Q1/6844 ,  C12Q1/6869

公开(公告)号：EP3327139A1

公开(公告)日：2018-05-30

申请号：EP17191835.2

申请日：2010-04-06

申请人： The Johns Hopkins University ,  Case Western Reserve University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth ,  LI, Ming ,  DIAZ, Luis ,  PAPADOPOULOS, Nickolas ,  MARKOWITZ, Sanford

IPC分类号： C12Q1/68 ,  C12N15/11 ,  G01N33/52

CPC分类号： C12Q1/6816 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2565/501 ,  C12Q2527/125 ,  C12Q2523/125

摘要： Abnormal DNA methylation can be used as a biomarker in cancer patients. For such purposes, it is important to determine precisely the fraction of methylated molecules in an analyzed sample. A technology we term Methyl-BEAMing achieves this goal. Individual bisulfite-treated DNA molecules can be PCR-amplified within aqueous nanocompartments containing beads, resulting in a population of beads each containing thousands of copies of the template molecule. After hybridization with probes specific for methylated sequences, the beads can be analyzed by flow cytometry. This approach enables detection and enumeration of one methylated molecule in a population of ∼5000 unmethylated molecules. Methyl-BEAMing provides digital quantification of rare methylation events and is generally applicable to the assessment of methylated genes in clinical samples.

公开(公告)号：EP3079598A1

公开(公告)日：2016-10-19

申请号：EP14870556.9

申请日：2014-12-12

申请人： Case Western Reserve University

发明人： MARKOWITZ, Sanford ,  CHAK, Amitabh ,  WILLIS, Joseph ,  TAGGART, Jeffrey Silver ,  BLICE, Rebecca ,  SECREST, Dean ,  SIEDLAK, Dennis

IPC分类号： A61B10/02

CPC分类号： A61B10/02 ,  A61B2010/0216 ,  A61B2010/0225

摘要： A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：EP3781154A1

公开(公告)日：2021-02-24

申请号：EP19780850.4

申请日：2019-04-04

申请人： CASE WESTERN RESERVE UNIVERSITY ,  Inje Industry Academic Cooperation Foundation

发明人： MARKOWITZ, Sanford ,  BAE, Ki Beom ,  KIM, Hye Jung ,  KIM, Sun-Hee

IPC分类号： A61K31/395 ,  A61K31/41 ,  A61K31/426 ,  A61K31/4365

公开(公告)号：EP3630773A1

公开(公告)日：2020-04-08

申请号：EP18806116.2

申请日：2018-05-29

申请人： Case Western Reserve University ,  Board of Regents, The University of Texas System

发明人： MARKOWITZ, Sanford ,  ANTCZAK, Monika ,  READY, Joseph ,  ZHANG, Youngyou

IPC分类号： C07D487/04

公开(公告)号：EP3618724A1

公开(公告)日：2020-03-11

申请号：EP18794027.5

申请日：2018-05-03

申请人： Case Western Reserve University

发明人： MARKOWITZ, Sanford ,  SECREST, Dean ,  CHAK, Amitabh ,  WILLIS, Joseph ,  SIEDLAK, Dennis

IPC分类号： A61B10/02 ,  A61B17/22 ,  A61B17/32