-
11.发明公开
公开(公告)号：EP3807295A1
公开(公告)日：2021-04-21
申请号：EP19729797.1
申请日：2019-06-17
申请人： College de France , Ecole Normale Supérieure , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , SORBONNE UNIVERSITE , Centre National de la Recherche Scientifique (CNRS)
-
12.发明公开UTILISATION D'UN INHIBITEUR DE TRANSCRIPTASE INVERSE DANS LA PREVENTION ET LE TRAITEMENT DES MALADIES DEGENERATIVES 审中-公开利用联合国禁止转录酶反转染色体防止染色体畸变的方法
公开(公告)号：EP3212200A1
公开(公告)日：2017-09-06
申请号：EP15798211.7
申请日：2015-10-30
申请人： Centre National de la Recherche Scientifique , College de France , INSERM - Institut National de la Santé et de la Recherche Médicale , Université Pierre et Marie Curie
发明人： PROCHIANTZ, Alain , FUCHS, Julia , JOSHI, Rajiv , BLAUDIN DE THE, François Xavier , REKAIK, Hocine , MASSIANI-BEAUDOIN, Olivia
IPC分类号： A61K31/7072 , A61P25/28
CPC分类号： C12N15/113 , A61K31/7072 , C12N15/63 , C12N2740/00011 , C12Q1/25 , C12Q1/68
摘要： The invention relates to the use of a reverse-transcriptase inhibitor in the prevention or treatment of a degenerative disease.
摘要翻译： 本发明涉及逆转录酶抑制剂在预防或治疗退行性疾病中的用途。
-
13.发明公开UTILISATION DE LA PROTEINE A HOMEODOMAINE ENGRAILED COMME ANXIOLYTIQUE 有权Verwendung ENGRAILEDHOMEODOMÄNEN蛋白ALS ANXIOLYTIKUM的
公开(公告)号：EP1993587A2
公开(公告)日：2008-11-26
申请号：EP07731062.1
申请日：2007-02-28
CPC分类号： A61K38/1709
摘要： The present invention relates to the use of an Engrailed transcription factor for producing a medicament for anxiolytic purposes.
-
公开(公告)号：EP1625152A2
公开(公告)日：2006-02-15
申请号：EP04742777.8
申请日：2004-05-19
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Ecole Normale Superieure , Universite Paris 13
CPC分类号： C07K7/08 , A61K38/00 , C07K19/00 , C07K2319/00
摘要： The invention relates to peptides which can become fixed to the engrailed transcription factor and which can modulate the activity thereof.
摘要翻译： 本发明涉及可以固定到有刻痕的转录因子并且可以调节其活性的肽。
-
公开(公告)号：EP3352777A1
公开(公告)日：2018-08-01
申请号：EP16777596.4
申请日：2016-09-23
申请人： Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale (INSERM) , College de France , Sorbonne Université
发明人： PROCHIANTZ, Alain
CPC分类号： A61K38/17
摘要： The present invention relates to the use of a homeoprotein or a recombinant vector encoding said protein for treating or preventing DNA damage and/or cellular aging. In particular, the invention concerns the use of Engrailed for the treatment of Parkinson disease.
-
公开(公告)号：EP1351648B1
公开(公告)日：2014-04-16
申请号：EP01996347.9
申请日：2001-11-20
发明人： JOLIOT, Alain , DUPONT, Edmond , PROCHIANTZ, Alain
CPC分类号： B82Y5/00 , A61K38/1709 , A61K47/64 , A61K47/665
-
公开(公告)号：EP2387579B1
公开(公告)日：2014-03-12
申请号：EP10704386.1
申请日：2010-01-19
CPC分类号： A61K38/465 , A61K38/1709 , A61K47/62 , C07K14/47 , C07K14/4702 , C07K2319/33 , C12N9/16 , C12Y301/03001
-
18.发明公开POLYPEPTIDES D'ADRESSAGE SPECIFIQUE A DES CELLULES-CIBLES D'OTX2 有权多肽FÜRDAS SPEZIFISCHE TARGETING GEGEN OTX2-TARGETZELLEN
公开(公告)号：EP2387579A1
公开(公告)日：2011-11-23
申请号：EP10704386.1
申请日：2010-01-19
IPC分类号： C07K7/08
CPC分类号： A61K38/465 , A61K38/1709 , A61K47/62 , C07K14/47 , C07K14/4702 , C07K2319/33 , C12N9/16 , C12Y301/03001
摘要： The invention relates to polypeptides which enable the specific targeting of a molecule of interest to homeoprotein Otx2 target cells. These polypeptides are defined by the general sequence: B
1 B
2 X
1 B
3 B
4 X
2 B
5 X
3 X
4 X
5 X
6 B
6 X
7 X
8 X
9 (SEQ ID NO: 1), in which: B
1 , B
2 , B
3 , B
4 , B
5 and B
6 are independently arginine or lysine; X
1 and X
8 are independently asparagine or glutamine; X
2 is aspartic acid or glutamic acid; X
3 , X
4 and X
6 are independently threonine or serine; X
5 is phenylalanine, tyrosine or tryptophan; X
7 represents alanine or glycine; X
9 is leucine, isoleucine or valine.摘要翻译： 本公开提供了将多肽分子递送至Otx2靶细胞的方法，包括使靶细胞与嵌合多肽接触，所述嵌合多肽具有（i）由SEQ ID NO：2组成的靶向肽和（ii）多肽分子。
-
19.发明公开UTILISATION D'UNE HOMEOPROTEINE DE LA FAMILLE BICOÏD POUR LA PREVENTION OU LE TRAITEMENT DE LA DEGENERESCENCE DES NEURONES GANGLIONNAIRES RETINIENS 有权THE homeoprotein bicoid家庭为预防和治疗视网膜GANGL离子神经元变性的使用
公开(公告)号：EP2240197A2
公开(公告)日：2010-10-20
申请号：EP09715010.6
申请日：2009-01-09
CPC分类号： A61K38/17
摘要： The invention relates to the use of a homeoprotein of the bicoid family, in particular of the Otx family, for enhancing the survival of cultivated retinal ganglion neurones, and for preventing or treating ganglion neurone degeneration particularly occurring in glaucoma.
-
20.发明授权APPLICATIONS DE PEPTIDES ISSUS DU DOMAINE CYTOPLASMIQUE DU PRECURSEUR DE LA PROTEINE AMYLOIDE (APP) 有权肽从域细胞质的淀粉样前体蛋白中的应用（APP）
公开(公告)号：EP1200458B1
公开(公告)日：2007-02-14
申请号：EP00958641.3
申请日：2000-07-28
CPC分类号： C07K14/4711 , A61K38/00
摘要： The invention concerns novel uses of peptides derived from the cytoplasmic domain of the amyloid protein precursor (APP); said peptides are in particular sequences including the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP) (one-letter code), selected in the group consisting of the sequences Y1KQYTSIHHGY0 (SEQ ID NO:2), Y1KKQYTSIHHGY0 (SEQ ID NO:3) and Y1KKKQYTSIHHGY0 (SEQ ID NO:4), wherein Y0 is nil or represents V, VV, VVE, VVEV or VVVED and Y1 represents an internalisation and addressing peptide, derived from the 3 helix of homeodomains and structurally related peptides. The invention also concerns the use of a peptide comprising the membrane domain juxtaposed to the cytoplasmic domain of the amyloid protein precursor (APP), for selecting and screening products capable of inhibiting apoptosis.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.017 秒)
