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公开(公告)号：EP3044587A1
公开(公告)日：2016-07-20
申请号：EP14842237.1
申请日：2014-09-09
申请人： Chu Sainte-Justine
IPC分类号： G01N33/48 , A61F5/02 , A61K31/4045 , A61K31/7105 , A61K33/04 , A61K38/08
CPC分类号： G01N33/6893 , A61F5/02 , A61F5/026 , A61K31/4045 , A61K31/713 , A61K33/04 , A61K38/19 , A61K45/06 , C12N15/1138 , C12N2310/14 , C12N2320/30 , G01N33/48728 , G01N2333/47 , G01N2333/726 , G01N2800/10 , G01N2800/50 , G01N2800/52 , A61K2300/00
摘要： The present invention provides a method of treating a subject in need thereof comprising classifying the subject into functional group FG1, FG2 or FG3, wherein i) when the subject is classified into the FG1 functional group, (A) the level of OPN or the activity of OPN in said subject is increased; (B) the subject is not treated with a brace; or (C) a combination of (A) and (B); and ii) when the subject is classified into the FG2 or FG3 functional group, (A) the level of OPN or the activity of OPN in said subject is decreased; (B) the subject is treated with a brace; or (C) a combination of (A) and (B).
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12.发明公开GI PROTEIN PHOSPHORYLATION AS MARKER FOR SCOLIOSIS AND SCOLIOSIS PROGRESSION, METHODS OF INCREASING GIPCR SIGNALING IN SCOLIOTIC SUBJECTS 审中-公开GI蛋白质磷酸化作为标记物时脊柱侧弯脊柱侧弯的进展和方法以增加GIPCR信令脊柱侧弯PEOPLE
公开(公告)号：EP3011331A1
公开(公告)日：2016-04-27
申请号：EP14813743.3
申请日：2014-06-16
申请人： CHU Sainte-Justine
IPC分类号： G01N33/48 , A61K31/18 , A61K31/404 , A61K31/4439 , A61K31/472 , A61K31/473
CPC分类号： G01N33/6872 , A61K31/18 , A61K31/4188 , A61K31/4427 , A61K31/4745 , G01N33/6893 , G01N2333/4704 , G01N2440/14 , G01N2800/10 , G01N2800/38 , G01N2800/50 , G01N2800/52
摘要： Kits for stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's Giα protein serine phosphorylation profile and/or the degree of imbalance in G-protein coupled receptor responses to Giα and Gsα protein stimulation. In some embodiments, the methods involve detecting or determining the level of serine phosphorylated Giα1 and/or Giα3 proteins in the cell sample, and/or determining a ratio between the response to Giα protein stimulation and the response to Gsα protein stimulation from a biological sample from the subject. Kits for predicting the risk of an AIS subject for developing a severe scoliosis, for predicting the subject's responsiveness to bracing treatment, and for identifying therapeutically useful compounds are also provided.
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13.发明公开METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS THROUGH THE USE OF GI PROTEIN RECEPTOR 有权分类程序脊柱侧弯诊断中的应用一GI蛋白偶联受体
公开(公告)号：EP2331962A1
公开(公告)日：2011-06-15
申请号：EP09818732.1
申请日：2009-10-13
申请人： Chu Sainte-Justine
IPC分类号： G01N33/567 , G01N27/02 , C12Q1/00
CPC分类号： G01N33/74 , G01N33/5008 , G01N33/566 , G01N33/6872 , G01N2333/4719 , G01N2333/726 , G01N2800/10 , G01N2800/38
摘要： Methods for diagnosing a predisposition to developing a scoliosis (e g, adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protem-coupled receptor activity are described The methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand If the impedance is higher in the presence of the test compound when compared to in the absence of the test compound, then the test compound is useful in treating the scoliosis.
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