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    A METHOD OF INCREASING GIPCR SIGNALIZATION IN THE CELLS OF A SCOLIOTIC SUBJECT
    2.
    发明公开
    A METHOD OF INCREASING GIPCR SIGNALIZATION IN THE CELLS OF A SCOLIOTIC SUBJECT 审中-公开
    DEN ZELLEN EINER SKOLIOTICHEN PERSON VERFAHREN ZURERHÖHUNGDER GIPCR-SIGNALISIERUNG

    公开(公告)号：EP3010541A1

    公开(公告)日：2016-04-27

    申请号：EP14814185.6

    申请日：2014-06-17

    申请人： Chu Sainte-Justine

    发明人： MOREAU, Alain ,  AKOUME NDONG, Marie-Yvonne

    IPC分类号： A61K39/395 ,  A61K31/713 ,  A61P19/08 ,  C07H21/00 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/53

    CPC分类号： C07K16/2839 ,  A61K31/713 ,  A61K39/3955 ,  C07K16/24 ,  C07K16/2884 ,  C07K2317/76 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N33/74 ,  G01N2333/70585 ,  G01N2800/10 ,  G01N2800/50

    摘要： There is provided a method of increasing GIPCR signalization in the cells of a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of integrin alpha5beta1 expression and/or activity, whereby GiPCR signalization is increased in the cells of the subject. An inhibitor of integrin alph5beta1 may be, for example, an agent that inhibits the interaction between f osteopontin (OPN) and integrin alpha5beta1. Also provided are methods of determining the risk of developing a scoliosis and based on the presence of at least one copy of a CD44 risk allele and methods of stratifying a subject having a scoliosis and kits for performing these methods. In particular, the method of determining risk identifies SNP rs1467558; an isoleucine to threonine mutation at position 230 of CD44.

    摘要翻译： 提供了在有需要的受试者的细胞中增加GIPCR信号传导的方法，包括向受试者施用有效量的整合素α5β1表达和/或活性的抑制剂，由此在受试者的细胞中GiPCR信号传导增加。 整合素α1bβ1的抑制剂可以是例如抑制骨桥蛋白（OPN）和整联蛋白α5β1之间相互作用的药剂。 还提供了确定发展脊柱侧凸的风险的方法，并且基于CD44风险等位基因的至少一个拷贝的存在以及分层具有脊柱侧凸的受试者的方法和用于进行这些方法的试剂盒的方法。 特别是，确定风险的方法识别SNP rs1467558; CD44的位置230处的异亮氨酸与苏氨酸突变。

    NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS
    4.
    发明公开
    NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS 审中-公开

    公开(公告)号：EP3647789A1

    公开(公告)日：2020-05-06

    申请号：EP19186693.8

    申请日：2014-09-09

    申请人： Chu Sainte-Justine

    发明人： MOREAU, Alain ,  AKOUME NDONG, Marie-Yvonne

    IPC分类号： G01N33/68 ,  A61F5/02 ,  A61K31/4045 ,  A61K31/7105 ,  A61K33/04 ,  A61K38/08

    摘要： A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS or a method of determining the risk of developing IS in a subject, wherein the IS is preferably adolescent IS (AIS), comprising: A) a) contacting a cell sample from the subject with i) an agonist of cluster I or cluster II GiPCR; and ii) Pertussis toxin (PXT); b) determining the cellular response to Gi stimulation; and c) classifying said subject into a IS functional group according to the subject's cellular response profile; or B) a) contacting a cell sample from the subject with an agonist of a cluster II GiPCR; b) determining the cellular response to Gi protein stimulation by cellular impedance; and c) classifying the subject into a IS functional group according to the subject's cellular impedance profile. A corresponding kit is also disclosed. A method of selecting a preventive measure, treatment or follow-up schedule for a subject suffering from IS or at risk of developing IS, wherein the IS is preferably adolescent IS (AIS), comprising classifying the subject using at least one of the method as defined above and classifying the subject in functional groups FG1-FG3 based on levels of OPN, HA,CD44, the frequency a of scoliosis assessment or the prescription of corrective surgery prior to reaching a Cobb's angle of 45 degrees.