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    IN SITU BIOPROSTHETIC FILLER AND METHODS, PARTICULARLY FOR THE IN SITU FORMATION OF VERTEBRAL DISC BIOPROSTHETICS
    11.
    发明公开
    IN SITU BIOPROSTHETIC FILLER AND METHODS, PARTICULARLY FOR THE IN SITU FORMATION OF VERTEBRAL DISC BIOPROSTHETICS 有权
    人工生物填料和方法，特别是对于BANDSCHEIBENBIOPROTHESEN的原地地层

    公开(公告)号：EP1328220A2

    公开(公告)日：2003-07-23

    申请号：EP01984004.0

    申请日：2001-10-24

    申请人： CryoLife, Inc.

    发明人： YUKSEL, K., Umit ,  WALSH, Steven, P. ,  BLACK, Kirby, S.

    IPC分类号： A61F2/44

    CPC分类号： A61L27/3691 ,  A61F2002/4445 ,  A61F2002/445 ,  A61L27/18 ,  A61L27/22 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/3658 ,  A61L27/40 ,  C08L71/02

    摘要： Bioprosthetic devices (10) include an exterior biological tissue member (10-1) which at least partly defines a cavity, and a proteinaceous biopolymer (10-2) which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device (10) is a bioprosthetic vertebral disc, having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer (10-2). Preferably, the proteinaceous biopolymer (10-2) is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.