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13 条记录 (耗时 0.015 秒)

    BIOPROSTHETIC FILLER AND METHODS, PARTICULARLY FOR THE IN SITU FORMATION OF VERTEBRAL DISC BIOPROSTHETICS
    2.
    发明授权
    BIOPROSTHETIC FILLER AND METHODS, PARTICULARLY FOR THE IN SITU FORMATION OF VERTEBRAL DISC BIOPROSTHETICS 有权
    人工生物填料和方法，特别是对于BANDSCHEIBENBIOPROTHESEN的原地地层

    公开(公告)号：EP1328220B1

    公开(公告)日：2011-01-05

    申请号：EP01984004.0

    申请日：2001-10-24

    申请人： CryoLife, Inc.

    发明人： YUKSEL, K., Umit ,  WALSH, Steven, P. ,  BLACK, Kirby, S.

    IPC分类号： A61L27/22 ,  A61L27/36 ,  A61F2/44

    CPC分类号： A61L27/3691 ,  A61F2002/4445 ,  A61F2002/445 ,  A61L27/18 ,  A61L27/22 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/3658 ,  A61L27/40 ,  C08L71/02

    摘要： Bioprosthetic devices (10) include an exterior biological tissue member (10-1) which at least partly defines a cavity, and a proteinaceous biopolymer (10-2) which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device (10) is a bioprosthetic vertebral disc, having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer (10-2). Preferably, the proteinaceous biopolymer (10-2) is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.

    EXPANDABLE FOAM-LIKE BIOMATERIALS AND METHODS
    4.
    发明授权
    EXPANDABLE FOAM-LIKE BIOMATERIALS AND METHODS 有权
    可膨胀的泡沫样生物材料和方法

    公开(公告)号：EP1416946B1

    公开(公告)日：2017-12-20

    申请号：EP01273879.5

    申请日：2001-11-07

    申请人： CryoLife, Inc.

    发明人： YUKSEL, K., Umit ,  BIRD, Ana, T. ,  BLACK, Kirby, S.

    IPC分类号： A61L27/22 ,  A61L27/56

    CPC分类号： A61L27/56 ,  A61L27/22

    摘要： Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.

    EXPANDABLE FOAM-LIKE BIOMATERIALS AND METHODS
    5.
    发明公开
    EXPANDABLE FOAM-LIKE BIOMATERIALS AND METHODS 有权
    维生素B的生物制剂

    公开(公告)号：EP1416946A2

    公开(公告)日：2004-05-12

    申请号：EP01273879.5

    申请日：2001-11-07

    申请人： CryoLife, Inc.

    发明人： YUKSEL, K., Umit ,  BIRD, Ana, T. ,  BLACK, Kirby, S.

    IPC分类号： A61K35/55 ,  A61K38/38

    CPC分类号： A61L27/56 ,  A61L27/22

    摘要： Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.

    摘要翻译： 将液体，可注射的水溶液原位转化为可膨胀的泡沫状，空间填充和粘附的生物材料。 优选地，泡沫状生物材料是两部分液体体系实现其原位形成的反应产物。 液体系统通常由蛋白质溶液和交联剂溶液组成，其可以预混合，然后施用于需要生物材料的部位，或同时混合并通过直接混合/分配尖端直接递送到该部位 。 在特别优选的实施方案中，可发泡泡沫状生物材料包括人或动物衍生的蛋白质材料与二醛或多醛在碳酸氢盐存在下的反应产物和足以赋予材料泡沫结构的酸性滴定剂的量 。

    RADICAL RETARDANT CRYOPRESERVATION SOLUTIONS
    7.
    发明公开
    RADICAL RETARDANT CRYOPRESERVATION SOLUTIONS 审中-公开
    自由基保护剂冷冻保存液

    公开(公告)号：EP1569511A1

    公开(公告)日：2005-09-07

    申请号：EP03813016.7

    申请日：2003-12-11

    申请人： CryoLife, Inc.

    发明人： GOLDSTEIN, Steven ,  HAMBY, Joseph ,  WALSH, Steven, P. ,  BLACK, Kirby, S.

    IPC分类号： A01N1/02

    CPC分类号： A01N1/0215 ,  A01N1/02

    摘要： A novel solution for cryopreservation of a tissue that includes water, a bio­compatible buffer, a cell-impermeant constituent, a cell-permeant constituent, and a radical scavenger is disclosed. The solution may be used to preserve the tissue for later transplantation in an animal, including human, host. The radical scavenger is believed to reduce damage to the tissue that could otherwise occur during sterilization with ionizing radiation.

    摘要翻译： 公开了用于冷冻包含水，生物相容性缓冲液，细胞渗透性成分，细胞渗透性成分和自由基清除剂的组织的新型溶液。 可以使用该溶液来保存组织，以便随后在包括人，宿主的动物中移植。 据信自由基清除剂可减少在用电离辐射灭菌期间可能发生的组织损伤。