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    ARYL SUBSTITUTED PYRIMIDINES AND THE USE THEREOF
    12.
    发明授权
    ARYL SUBSTITUTED PYRIMIDINES AND THE USE THEREOF 有权
    芳基取代嘧啶和它们的用途

    公开(公告)号：EP1483247B1

    公开(公告)日：2009-06-24

    申请号：EP03719019.6

    申请日：2003-03-13

    申请人： EURO-CELTIQUE S.A.

    发明人： GOEHRING, R., Richard ,  VICTORY, Sam, F. ,  KYLE, Donald, J.

    IPC分类号： C07D239/46 ,  C07D239/32 ,  A61K31/505 ,  A61P25/00

    CPC分类号： C07D239/42 ,  C07D239/47

    摘要： This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula (I): or a pharmaceutically acceptable salt, or solvate thereof, wherein A, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

    HETEROCYCLIC SUBSTITUTED 2- (4-PHENOXY) PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEURONAL DAMAGE AND NEURODEGENERATIVE CONDITIONS
    14.
    发明公开
    HETEROCYCLIC SUBSTITUTED 2- (4-PHENOXY) PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEURONAL DAMAGE AND NEURODEGENERATIVE CONDITIONS 审中-公开
    杂环取代的2-（4-苯氧基）吡啶衍生物和相关化合物作为钠通道阻滞剂用于治疗神经元损伤和神经变性疾病

    公开(公告)号：EP1432424A1

    公开(公告)日：2004-06-30

    申请号：EP02770470.9

    申请日：2002-09-06

    申请人： Euro-Celtique S.A.

    发明人： SHAO, Bin ,  GOEHRING, R., Richard

    IPC分类号： A61K31/5377 ,  A61K31/4545 ,  C07D413/04 ,  C07D213/68 ,  C07D213/74 ,  C07D213/79 ,  C07D213/81

    CPC分类号： C07D213/64 ,  C07D213/81

    摘要： This invention relates to aryl substituted pyridines of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: Ar is selected from the group consisting of Ar1, Ar2, Ar3 and Ar4, wherein Ar1 is R1 is selected from the group consisting of an optionally substituted alkyl, amino, alkylthiol, C(O)R10, SO2R10, and OC(O)NH2; R2 is Ym-(CH2)n-Z, wherein Y is O, S or NR11, wherein R11 is hydrogen or alkyl, Z is a saturated heterocyclic ring optionally substituted at one or more carbon atoms, m is 0 or 1, and n is 0-6; or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyothrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, including diabetic neuropathy, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, and as antiarrhythmics.