公开(公告)号：EP1385515B1

公开(公告)日：2008-08-06

申请号：EP02739163.0

申请日：2002-04-18

申请人： EURO-CELTIQUE S.A.

发明人： GOEHRING, R., Richard ,  KYLE, Donald ,  LEE, Gary ,  GHARAGOZLOO, Parviz ,  VICTORY, Sam

IPC分类号： A61K31/438 ,  C07D471/10 ,  A61P25/04

CPC分类号： C07D471/10

摘要： A compound of Formula (I) wherein Z, W, A, B, C, R1, R2, Q and n are as disclosed herein.

摘要翻译： 其中Z，W，A，B，C，R 1，R 2，Q和n如本文所公开的式（I）化合物。

公开(公告)号：EP1379246B1

公开(公告)日：2008-10-08

申请号：EP02764236.2

申请日：2002-04-18

申请人： EURO-CELTIQUE S.A.

发明人： SUN, Qun ,  GOEHRING, R., Richard ,  KYLE, Donald ,  CHEN, Zhengming ,  VICTORY, Sam ,  WHITEHEAD, John

IPC分类号： A61K31/44 ,  A61K31/48 ,  A61K31/415 ,  A61K31/445 ,  C07D211/04 ,  C07D211/06 ,  C07D235/24 ,  C07D413/04 ,  C07D235/26 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  A61P25/04

CPC分类号： C07D401/04 ,  C07D235/26 ,  C07D263/58 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： A compound of formula (I), (II), (III) or (IV), wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.

公开(公告)号：EP1537110B1

公开(公告)日：2007-01-17

申请号：EP00982458.2

申请日：2000-12-06

申请人： Euro-Celtique, S.A.

发明人： KYLE, Donald ,  GOEHRING, R., Richard

IPC分类号： C07D471/10 ,  A61K31/445 ,  C07D235/00 ,  C07D221/00

CPC分类号： A61K31/00 ,  A61K31/445 ,  C07D471/10 ,  Y10S514/812

摘要： Disclosed are compounds of formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.

公开(公告)号：EP1432419A1

公开(公告)日：2004-06-30

申请号：EP02773292.4

申请日：2002-09-06

申请人： Euro-Celtique S.A.

发明人： SHAO, Bin ,  GOEHRING, R., Richard ,  VICTORY, Samuel, F. ,  SUN, Qun

IPC分类号： A61K31/4418 ,  C07D213/82 ,  C07D213/81 ,  A61P23/00 ,  A61P25/08 ,  A61P9/06

CPC分类号： C07D213/81 ,  C07D213/82 ,  Y10T436/145555

摘要： This invention relates aryl substituted pyridines of Formula (I),or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

公开(公告)号：EP1385518B1

公开(公告)日：2008-08-06

申请号：EP02764243.8

申请日：2002-04-18

申请人： EURO-CELTIQUE S.A.

发明人： GOEHRING, R., Richard ,  CHEN, Zhengming ,  KYLE, Donald ,  VICTORY, Sam

IPC分类号： A61K31/4523 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/519 ,  A61K31/53 ,  C07D401/04 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  A61P25/00 ,  A61K31/435

CPC分类号： C07D401/04

摘要： Disclosed are compounds of the formula (I): wherein A, B, C, M1-M4, R, R1, R2 and n are as described herein.

公开(公告)号：EP1483247A2

公开(公告)日：2004-12-08

申请号：EP03719019.6

申请日：2003-03-13

申请人： Euro-Celtique S.A.

发明人： GOEHRING, R., Richard ,  VICTORY, Sam, F. ,  KYLE, Donald, J.

IPC分类号： C07D239/46 ,  C07D239/32 ,  A61K31/505 ,  A61P25/00

CPC分类号： C07D239/42 ,  C07D239/47

摘要： This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula (I): or a pharmaceutically acceptable salt, or solvate thereof, wherein A, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

公开(公告)号：EP1385515A1

公开(公告)日：2004-02-04

申请号：EP02739163.0

申请日：2002-04-18

申请人： EURO-CELTIQUE S.A.

发明人： GOEHRING, R., Richard ,  KYLE, Donald ,  LEE, Gary ,  GHARAGOZLOO, Parviz ,  VICTORY, Sam

IPC分类号： A61K31/438 ,  C07D471/10

CPC分类号： C07D471/10

摘要： A compound of Formula (I) wherein Z, W, A, B, C, R1, R2, Q and n are as disclosed herein.

公开(公告)号：EP1711484A1

公开(公告)日：2006-10-18

申请号：EP05726385.7

申请日：2005-02-02

申请人： EURO-CELTIQUE S.A.

发明人： GOEHRING, R., Richard ,  WHITEHEAD, John ,  SHAO, Bin

IPC分类号： C07D401/04 ,  C07D221/00

CPC分类号： C07D471/10 ,  C07D401/04

摘要： Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

摘要翻译： 在某些实施方案中公开了合成式（V）化合物及其盐的方法。

公开(公告)号：EP1551400A2

公开(公告)日：2005-07-13

申请号：EP03770760.1

申请日：2003-10-16

申请人： Euro-Celtique S.A.

发明人： GHARAGOZLOO, Parvis ,  LEE, Gary ,  GOEHRING, R., Richard

IPC分类号： A61K31/438 ,  C07D471/10

CPC分类号： C07D471/10

摘要： The present invention relates to processes for producing triazospiro compounds having the formula (IV): wherein A, B. C. R, R1, and W are as defined herein.

公开(公告)号：EP1385518A1

公开(公告)日：2004-02-04

申请号：EP02764243.8

申请日：2002-04-18

申请人： EURO-CELTIQUE S.A.

发明人： GOEHRING, R., Richard ,  CHEN, Zhengming ,  KYLE, Donald ,  VICTORY, Sam,

IPC分类号： A61K31/4523 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/519 ,  A61K31/53 ,  C07D401/04 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D401/04

摘要： Disclosed are compounds of the formula (I): wherein A, B, C, M1-M4, R, R1, R2 and n are as described herein.