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11.NUCLEIC ACIDS ENCODING CD40/CD40L CHIMERIC POLYPEPTIDES, METHODS FOR THEIR PRODUCTION AND USES THEREOF 审中-公开
标题翻译: NUKLEOTIDENSÄURE编码CD40 / CD40L嵌合多肽,方法生产及其用途公开(公告)号:EP1173589A1
公开(公告)日:2002-01-23
申请号:EP00918873.1
申请日:2000-04-13
发明人: DICKER, Frank , FRIESS, Thomas , MAASS, Gerd , PESSARA, Ulrich , SCHEUER, Werner , SEEBER, Stefan
IPC分类号: C12N15/62 , C07K14/705 , C07K19/00 , C12N5/10 , A61K48/00
CPC分类号: C07K14/70578 , A61K38/00 , A61K48/00
摘要: A nucleic acid encoding a chimeric polypeptide comprising nucleic acid fragments encoding i) a mammalian signal peptide and downstream thereof, ii) the binding and trimerization domain of CD40L and downstream thereof, iii) a spacer of 50 to 100 amino acids and downstream thereof, iv) the transmembrane and signal transduction domains of CD40, is useful as a gene therapy agent for the local treatment of solid tumors.
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公开(公告)号:EP3990484A1
公开(公告)日:2022-05-04
申请号:EP20734039.9
申请日:2020-06-25
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公开(公告)号:EP3947437A1
公开(公告)日:2022-02-09
申请号:EP20713895.9
申请日:2020-03-26
IPC分类号: C07K14/735 , B01D15/38
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公开(公告)号:EP3606955A1
公开(公告)日:2020-02-12
申请号:EP18716573.3
申请日:2018-04-03
发明人: CODARRI DEAK, Laura , FISCHER, Jens , IMHOF-JUNG, Sabine , KLEIN, Christian , SEEBER, Stefan , WEBER, Patrick Alexander Aaron , PERRO, Mario
IPC分类号: C07K16/28
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公开(公告)号:EP3176178B1
公开(公告)日:2019-01-30
申请号:EP16203631.3
申请日:2012-11-21
发明人: ENDL, Josef , FISCHER, Jens , KERN, Peter , OFFNER, Sonja , PLATZER, Josef , SEEBER, Stefan
IPC分类号: C07K16/00 , C07K16/28 , C12N5/16 , C12N5/0781
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公开(公告)号:EP3356404A1
公开(公告)日:2018-08-08
申请号:EP16774499.4
申请日:2016-09-29
发明人: SEEBER, Stefan , LIFKE, Valeria , FISCHER, Jens , WEISER, Barbara , WUENSCHE, Ildiko , PLOETTNER, Oliver , ZWICK, Adrian , GEORGES, Guy , DENGL, Stefan , LEVITSKI, Viktor , KLEIN, Christian , CODARRI DEAK, Laura , FENN, Sebastian , BENZ, Joerg
IPC分类号: C07K16/28
CPC分类号: C07K16/2818 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to anti-PD1 antibodies and methods of using the same.
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公开(公告)号:EP2791174B1
公开(公告)日:2018-02-28
申请号:EP12798775.8
申请日:2012-12-12
发明人: FERTIG, Georg , FIDLER, Alexander , KALUZA, Klaus , RIES, Carola , SEEBER, Stefan , THOMAS, Marlene
IPC分类号: C07K16/28
CPC分类号: C07K16/2866 , C07K2317/33 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号:EP3176178A1
公开(公告)日:2017-06-07
申请号:EP16203631.3
申请日:2012-11-21
发明人: ENDL, Josef , FISCHER, Jens , KERN, Peter , OFFNER, Sonja , PLATZER, Josef , SEEBER, Stefan
IPC分类号: C07K16/00 , C07K16/28 , C12N5/16 , C12N5/0781
CPC分类号: C07K16/28 , C07K16/00 , C07K2317/14 , C12N5/0635 , C12N2501/2302 , C12N2501/2321 , C12N2501/52 , C12N2502/99 , C12N2510/00
摘要: Herein is reported a co-cultivation system for co-cultivating a pool of human B-cells or single deposited human B-cells wherein CD40L expressing mammalian cells are used as feeder in the presence of IL-2 and IL-21.
摘要翻译: 本文报道了用于共培养人B细胞或单个沉积的人B细胞库的共培养系统,其中表达CD40L的哺乳动物细胞在IL-2和IL-21存在下用作饲养细胞。
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公开(公告)号:EP3948281A1
公开(公告)日:2022-02-09
申请号:EP20712371.2
申请日:2020-03-25
IPC分类号: G01N33/543 , C07K16/00 , C07K16/06 , G01N33/68
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