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公开(公告)号：EP3606946A1
公开(公告)日：2020-02-12
申请号：EP18715008.1
申请日：2018-03-29
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公开(公告)号：EP1869087A2
公开(公告)日：2007-12-26
申请号：EP06723934.3
申请日：2006-03-31
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2317/24 , C07K2317/52 , C07K2317/565
摘要： An antibody binding to human CCR5 comprising a variable heavy chain and a variable light chain, characterized in that the variable heavy chain comprises CDR sequences CDRl, CDR2 and CDR3 and CDRl being selected from the group consisting of SEQ ID NOs: 9, 10, 11, 12, CDR2 being selected from the group consisting of SEQ ID NOs: 13, 14, 15, CDR3 being selected from the group consisting of SEQ ID NOs: 16, 17, wherein said CDRs are selected independently of each other, or is a chimeric, humanized variant or a fragment of said antibody, has advantageous properties for the treatment of immunosuppressive diseases.
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公开(公告)号：EP4201953A1
公开(公告)日：2023-06-28
申请号：EP22191366.8
申请日：2018-03-29
发明人： CODARRI DEAK, Laura , KLEIN, Christian , LAUENER, Laura , NICOLINI, Valeria G. , SEEBER, Stefan , UMAÑA, Pablo , WALDHAUER, Inja
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：EP3954709A1
公开(公告)日：2022-02-16
申请号：EP21182109.5
申请日：2016-09-29
发明人： CODARRI DEAK, Laura , FERTIG, Georg , FISCHER, Jens , KLEIN, Christian , LEVITSKI, Viktor , LIFKE, Valeria , PERRO, Mario , REGULA, Joerg Thomas , SCHLOTHAUER, Tilman , SEEBER, Stefan , UMAÑA, Pablo , WUENSCHE, Ildiko , ZWICK, Adrian
摘要： The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.
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公开(公告)号：EP3606954A1
公开(公告)日：2020-02-12
申请号：EP18715026.3
申请日：2018-04-03
发明人： CODARRI DEAK, Laura , DENGL, Stefan , FISCHER, Jens , KLEIN, Christian , SEEBER, Stefan , WEBER, Patrick Alexander Aaron , ZWICK, Adrian
IPC分类号： C07K16/28 , A61K39/395
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6.发明公开
公开(公告)号：EP3455248A1
公开(公告)日：2019-03-20
申请号：EP17725542.9
申请日：2017-05-11
发明人： FERRARA KOLLER, Claudia , CLAUS, Christina , KLEIN, Christian , SEEBER, Stefan , AMANN, Maria , GRAU-RICHARDS, Sandra , BRUENKER, Peter , UMANA, Pablo , LEVITSKI, Viktor , MOESSNER, Ekkehard
IPC分类号： C07K14/705 , A61K39/395 , C07K16/28 , C12N15/62
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公开(公告)号：EP3215532A1
公开(公告)日：2017-09-13
申请号：EP15790559.7
申请日：2015-11-05
发明人： LIFKE, Valeria , GEORGES, Guy , LEVITSKY, Victor , PLOETTNER, Oliver , SEEBER, Stefan , WEISER, Barbara , WUENSCHE, Ildiko , ZWICK, Adrian
CPC分类号： C07K16/2803 , A61K47/6803 , A61K47/6817 , A61K47/6829 , A61K47/6831 , A61K47/6849 , A61K47/6851 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides anti-TIM3 antibodies and methods of using the same.
摘要翻译： 本发明提供了抗TIM3抗体及其使用方法。
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公开(公告)号：EP2344537A1
公开(公告)日：2011-07-20
申请号：EP09736830.2
申请日：2009-10-07
发明人： BAEHNER, Monika , BRINKMANN, ULRICH , GEORGES, Guy , GRIEP, Remko, Albert , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , SEEBER, Stefan , THOMAS, Markus
IPC分类号： C07K16/22 , A61K39/395 , C07K19/00 , C07K16/46 , C07K14/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：EP1836226B1
公开(公告)日：2011-06-22
申请号：EP06706157.2
申请日：2006-01-02
发明人： ENDL, Josef , FUENTES, Maria , GRAUS, Yvo , GROSSMANN, Adelbert , NEUMANN, Sebastian , PARREN, Paul , REBERS, Frank , REGULA, Joerg , SCHUMACHER, Ralf , SEEBER, Stefan , STRACKE, Jan , STUBENRAUCH, Kay-Gunnar , VAN DE WINKEL, Jan , VAN VUGT, Martine , VEREECKEN-VERPLOEGEN, Sandra
IPC分类号： C07K16/28 , A61K39/395 , A61P11/06 , A61P37/08 , C12N15/13 , C12N15/79 , C12N15/70 , C12N5/10 , C12N5/20 , C12N1/21
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： An antibody binding to IL-13Rαl, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of said antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9 is useful in the treatment of asthma and allergic diseases.
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公开(公告)号：EP2134745A1
公开(公告)日：2009-12-23
申请号：EP08734921.3
申请日：2008-04-01
发明人： BRINKMANN, Ulrich , BRUENKER, Peter , FERRARA KOLLER, Claudia , LANZENDOERFER, Martin , REGULA, Joerg, Thomas , SCHLOTHAUER, Tilman , SEEBER, Stefan , ZECK, Anne
IPC分类号： C07K14/705
CPC分类号： C07K14/70535 , G01N2333/70535
摘要： The present invention relates to the field of human immunoglobulin receptors. It is herein reported the glycostructure of a human Fc gamma receptor HIa recombinantly expressed in human embryonic kidney cells and Chinese hamster ovary cells.
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