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公开(公告)号：EP3788043A1
公开(公告)日：2021-03-10
申请号：EP19722488.4
申请日：2019-04-29
发明人： CROWLEY, Brendan, M. , CAMPBELL, Brian, T. , CHOBANIAN, Harry, R. , FELLS, James, I. , GUIADEEN, Deodial, G. , GRESHOCK, Thomas, J. , LEAVITT, Kenneth, J. , RADA, Vanessa, L. , BELL, Ian, M.
IPC分类号： C07D413/14 , C07D413/04 , C07D417/04 , C07D417/14 , A61P25/00 , A61K31/438 , C07D401/04 , C07D471/04 , C07D471/08 , C07D487/04 , C07D513/04 , A61K31/439 , A61K31/444 , A61K31/501 , A61K31/506
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公开(公告)号：EP2888006B1
公开(公告)日：2019-04-24
申请号：EP13830714.5
申请日：2013-08-16
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： C07D471/04 , A61P3/10 , A61K31/4184 , A61K31/415 , A61K31/454
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公开(公告)号：EP3433234A1
公开(公告)日：2019-01-30
申请号：EP17714623.0
申请日：2017-03-20
发明人： CROWLEY, Brendan, M. , CAMPBELL, Brian, T. , DUFFY, Joseph, L. , GRESHOCK, Thomas, J. , GUIADEEN, Deodial, G. , HARVEY, Andrew John , HUFF, Belinda, C. , LEAVITT, Kenneth, J. , RADA, Vanessa, L. , SANDERS, John, M. , SHIPE, William, D. , SUEN, Linda, M. , BELL, Ian, M.
IPC分类号： C07D231/12 , C07D233/64 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D495/04 , C07D277/26 , C07D285/08 , C07D285/12
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公开(公告)号：EP2888006A1
公开(公告)日：2015-07-01
申请号：EP13830714.5
申请日：2013-08-16
发明人： APGAR, James, M. , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A61P3/10 , A61K31/4184 , A61K31/415 , A61K31/454
CPC分类号： C07D471/04 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/444 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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15.发明公开NOVEL BENZIMIDAZOLE HEXAHYDROFURO[3,2-B]FURAN DERIVATIVES 有权NEUARTIGE AZABENZIMIDAZOL HEXAHYDROFUR并[3,2-B] FURANDERIVATE
公开(公告)号：EP2887807A1
公开(公告)日：2015-07-01
申请号：EP13830916.6
申请日：2013-08-16
发明人： APGAR, James, M. , ARASAPPAN, Ashok , BIFTU, Tesfaye , CHEN, Ping , FENG, Danqing , GUIDRY, Erin , HICKS, Jacqueline, D. , KEKEC, Ahmet , LEAVITT, Kenneth, J. , LI, Bing , SEBHAT, Iyassu , QIAN, Xiaoxia , WEI, Lan , WILKENING, Robert, R. , WU, Zhicai
IPC分类号： A01N43/50 , A61K31/4184
CPC分类号： C07D493/04 , A61K31/366 , A61K31/397 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/427 , A61K31/454 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The novel benzimidazole hexahydrofuro[3,2-B]furan derivatives of the present invention are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
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