公开(公告)号：EP2049491B1

公开(公告)日：2010-10-20

申请号：EP07811106.9

申请日：2007-08-06

申请人： MILLENNIUM PHARMACEUTICALS, INC.

发明人： CLAIBORNE, Christopher, F. ,  CRITCHLEY, Stephen ,  LANGSTON, Steven, P. ,  OLHAVA, Edward, J. ,  PELUSO, Stephane ,  WEATHERHEAD, Gabriel, S. ,  VYSKOCIL, Stepan ,  VISIERS, Irache ,  MIZUTANI, Hirotake ,  CULLIS, Courtney

IPC分类号： C07D213/82 ,  C07D239/48 ,  C07D251/18 ,  C07D403/04 ,  C07D403/08 ,  C07D473/32 ,  C07D498/04 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D239/48 ,  C07D213/82 ,  C07D251/18 ,  C07D403/04 ,  C07D403/08 ,  C07D473/32 ,  C07D498/04

摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

公开(公告)号：EP1989206A2

公开(公告)日：2008-11-12

申请号：EP07763239.6

申请日：2007-01-31

申请人： MILLENNIUM PHARMACEUTICALS, INC.

发明人： LANGSTON, Steven, P. ,  OLHAVA, Edward, J. ,  VYSKOCIL, Stepan

IPC分类号： C07D471/04 ,  C07D473/34 ,  C07H19/14 ,  C07H19/16 ,  A61P35/00 ,  A61K31/519

CPC分类号： A61K31/519 ,  A61K31/52 ,  C07D403/04 ,  C07D405/14 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D519/00

摘要： This invention relates to compounds of formula (I) that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

摘要翻译： 本发明涉及抑制E1活化酶的式（I）化合物，包含该化合物的药物组合物和使用该化合物的方法。 这些化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎症和神经变性疾病; 和与感染和恶病质相关的炎症。