公开(公告)号：EP2049491A1

公开(公告)日：2009-04-22

申请号：EP07811106.9

申请日：2007-08-06

申请人： MILLENNIUM PHARMACEUTICALS, INC.

发明人： CLAIBORNE, Christopher, F. ,  CRITCHLEY, Stephen ,  LANGSTON, Steven, P. ,  OLHAVA, Edward, J. ,  PELUSO, Stephane ,  WEATHERHEAD, Gabriel, S. ,  VYSKOCIL, Stepan ,  VISIERS, Irache ,  MIZUTANI, Hirotake ,  CULLIS, Courtney

IPC分类号： C07D213/82 ,  C07D239/48 ,  C07D251/18 ,  C07D403/04 ,  C07D403/08 ,  C07D473/32 ,  C07D498/04 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D239/48 ,  C07D213/82 ,  C07D251/18 ,  C07D403/04 ,  C07D403/08 ,  C07D473/32 ,  C07D498/04

摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

公开(公告)号：EP1848718A1

公开(公告)日：2007-10-31

申请号：EP06734691.6

申请日：2006-02-02

申请人： MILLENNIUM PHARMACEUTICALS, INC.

发明人： CRITCHLEY, Stephen ,  GANT, Thomas, G. ,  LANGSTON, Steven, P. ,  OLHAVA, Edward, J. ,  PELUSO, Stephane

IPC分类号： C07D473/34 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07H19/16 ,  C07D405/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/048 ,  C07H19/14 ,  C07H19/23

摘要： This invention relates to compounds of formula (I-A) wherein Ring A and the variables X, Y, R3a, R3b, R3c, R3d, R4, R5, R5′, and m are defined herein. The compounds of formula (I-A) inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds of the invention are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

公开(公告)号：EP1848718B1

公开(公告)日：2012-08-01

申请号：EP06734691.6

申请日：2006-02-02

申请人： MILLENNIUM PHARMACEUTICALS, INC.

发明人： CRITCHLEY, Stephen ,  GANT, Thomas, G. ,  LANGSTON, Steven, P. ,  OLHAVA, Edward, J. ,  PELUSO, Stephane

IPC分类号： C07D473/34 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07H19/16 ,  C07D405/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/34 ,  C07D487/04 ,  C07H19/048 ,  C07H19/14 ,  C07H19/23

摘要： This invention relates to compounds of formula (I-A) wherein Ring A and the variables X, Y, R3a, R3b, R3c, R3d, R4, R5, R5′, and m are defined herein. The compounds of formula (I-A) inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds of the invention are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.

摘要翻译： 本发明涉及式（I-A）化合物，其中环A和变量X，Y，R 3a，R 3b，R 3c，R 3d，R 4，R 5，R 5'和m如本文所定义。 式（I-A）化合物抑制E1活化酶，包含该化合物的药物组合物和使用该化合物的方法。 本发明的化合物可用于治疗疾病，特别是细胞增殖病症，包括癌症，炎性和神经变性疾病; 和与感染和恶病质相关的炎症。

公开(公告)号：EP2049491B1

公开(公告)日：2010-10-20

申请号：EP07811106.9

申请日：2007-08-06

申请人： MILLENNIUM PHARMACEUTICALS, INC.

发明人： CLAIBORNE, Christopher, F. ,  CRITCHLEY, Stephen ,  LANGSTON, Steven, P. ,  OLHAVA, Edward, J. ,  PELUSO, Stephane ,  WEATHERHEAD, Gabriel, S. ,  VYSKOCIL, Stepan ,  VISIERS, Irache ,  MIZUTANI, Hirotake ,  CULLIS, Courtney

IPC分类号： C07D213/82 ,  C07D239/48 ,  C07D251/18 ,  C07D403/04 ,  C07D403/08 ,  C07D473/32 ,  C07D498/04 ,  A61K31/505 ,  A61P35/00

CPC分类号： C07D239/48 ,  C07D213/82 ,  C07D251/18 ,  C07D403/04 ,  C07D403/08 ,  C07D473/32 ,  C07D498/04

摘要： This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.