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11.发明公开PROCESS FOR THE PRODUCTION OF INTERMADIATES FOR THE PREPARATION OF TRICYCLIC BENZIMIDAZOLES 审中-公开于制备中间体，用于生产三环的苯并咪唑
公开(公告)号：EP1904454A2
公开(公告)日：2008-04-02
申请号：EP06763796.7
申请日：2006-06-20
申请人： Nycomed GmbH
发明人： CHIESA, Maria Vittoria , PALMER, Andreas , BUHR, Wilm , ZIMMERMANN, Peter Jan , BREHM, Christof , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang , ZANOTTI-GEROSA, Antonio
IPC分类号： C07D235/08 , C07F7/08 , C07D401/06 , C07D409/06 , C07D491/04 , A61K31/4188 , A61P1/00
CPC分类号： C07D235/08 , C07D401/06 , C07D409/06 , C07D491/04
摘要： The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
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公开(公告)号：EP1899338A1
公开(公告)日：2008-03-19
申请号：EP06763684.5
申请日：2006-06-13
申请人： Nycomed GmbH
发明人： ZIMMERMANN, Peter Jan , SENN-BILFINGER, Jörg , BREHM, Christof , BUHR, Wilm , CHIESA, Maria Vittoria , PALMER, Andreas , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang
IPC分类号： C07D471/10 , A61K31/438 , A61P1/04
CPC分类号： C07D471/10
摘要： The invention provides compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
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13.发明公开SUBSTITUTED IMIDAZO[4,5-b]PYRIDINES AS INHIBITORS OF GASTRIC ACID SECRETION 审中-公开取代的咪唑并[4,5-b]吡啶作为抑制剂胃酸分泌
公开(公告)号：EP1824850A2
公开(公告)日：2007-08-29
申请号：EP05850438.2
申请日：2005-12-06
申请人： Nycomed GmbH
发明人： BREHM, Christof , BUHR, Wilm , CHIESA, M. Vittoria , PALMER, Andreas , ZIMMERMANN, Peter Jan , SIMON, Wolfgang-Alexander , POSTIUS, Stefan , KROMER, Wolfgang
IPC分类号： C07D471/04 , A61K31/437 , A61P1/04
CPC分类号： C07D471/04
摘要： The invention provides compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
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公开(公告)号：EP1527066B1
公开(公告)日：2013-03-27
申请号：EP03747866.6
申请日：2003-07-26
申请人： Nycomed GmbH
发明人： KOHL, Bernhard , MÜLLER, Bernd , HUBER, Reinhard , HUMMEL, Rolf-Peter , KROMER, Wolfgang , POSTIUS, Stefan , SIMON, Wolfgang-Alexander , STURM, Ernst , HANAUER, Guido
IPC分类号： C07D401/12
CPC分类号： C07D401/12
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公开(公告)号：EP1912947A1
公开(公告)日：2008-04-23
申请号：EP06777980.1
申请日：2006-07-26
申请人： Nycomed GmbH
发明人： KOHL, Bernhard , MÜLLER, Bernd , HAAG, Dieter , SIMON, Wolfgang-Alexander , ZECH, Karl , DAVID, Michael , VON RICHTER, Oliver , HUTH, Felix
IPC分类号： C07D213/69 , C07D401/12 , A61P1/04 , A61K31/4439
CPC分类号： C07D401/12 , C07D213/69
摘要： The invention relates to compounds of formula 1 and to medicaments comprising these compounds, further to intermediates of formula 2 and 3.
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公开(公告)号：EP1718648B1
公开(公告)日：2008-04-23
申请号：EP05708021.0
申请日：2005-02-16
申请人： Nycomed GmbH
发明人： CHIESA, M. Vittoria , BUHR, Wilm , ZIMMERMANN, Peter Jan , BREHM, Christof , PALMER, Andreas , KROMER, Wolfgang , POSTIUS, Stefan , SIMON, Wolfgang-Alexander
IPC分类号： C07D471/14 , C07D471/04 , A61K31/435
CPC分类号： C07D471/04 , C07D471/14
摘要： The invention relates to compounds of the formula (1), in which the substituents R1, R2, R3 and Arom have the meanings as indicated in the description. The compounds are valuable intermediates for the preparation of pharmaceutical active compounds.
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公开(公告)号：EP1127059B1
公开(公告)日：2008-02-20
申请号：EP99953956.2
申请日：1999-10-29
申请人： Nycomed GmbH
发明人： GRUNDLER, Gerhard , POSTIUS, Stefan , SIMON, Wolfgang-Alexander , KROMER, Wolfgang , SENN-BILFINGER, Jörg
IPC分类号： C07D471/14 , A61K31/44
CPC分类号： C07D471/14
摘要： Compounds of formula (I), in which the substituents are as defined in the description are suitable for preventing and treating gastrointestinal disorders.
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