公开(公告)号：EP1934215A1

公开(公告)日：2008-06-25

申请号：EP06793674.0

申请日：2006-09-20

申请人： Nycomed GmbH

发明人： KOHL, Bernhard ,  ZIMMERMANN, Peter Jan ,  ZECH, Karl ,  BUHR, Wilm ,  PALMER, Andreas ,  BREHM, Christof ,  CHIESA, Maria Vittoria ,  KROMER, Wolfgang ,  POSTIUS, Stefan ,  SIMON, Wolfgang-Alexander ,  HOLST, Hans Christof

IPC分类号： C07D471/04 ,  C07D471/14 ,  A61K31/437 ,  A61P1/00

CPC分类号： C07D471/04 ,  C07B2200/05

摘要： The invention provides deuterated compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.

公开(公告)号：EP1904454A2

公开(公告)日：2008-04-02

申请号：EP06763796.7

申请日：2006-06-20

申请人： Nycomed GmbH

发明人： CHIESA, Maria Vittoria ,  PALMER, Andreas ,  BUHR, Wilm ,  ZIMMERMANN, Peter Jan ,  BREHM, Christof ,  SIMON, Wolfgang-Alexander ,  POSTIUS, Stefan ,  KROMER, Wolfgang ,  ZANOTTI-GEROSA, Antonio

IPC分类号： C07D235/08 ,  C07F7/08 ,  C07D401/06 ,  C07D409/06 ,  C07D491/04 ,  A61K31/4188 ,  A61P1/00

CPC分类号： C07D235/08 ,  C07D401/06 ,  C07D409/06 ,  C07D491/04

摘要： The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

公开(公告)号：EP1899338A1

公开(公告)日：2008-03-19

申请号：EP06763684.5

申请日：2006-06-13

申请人： Nycomed GmbH

发明人： ZIMMERMANN, Peter Jan ,  SENN-BILFINGER, Jörg ,  BREHM, Christof ,  BUHR, Wilm ,  CHIESA, Maria Vittoria ,  PALMER, Andreas ,  SIMON, Wolfgang-Alexander ,  POSTIUS, Stefan ,  KROMER, Wolfgang

IPC分类号： C07D471/10 ,  A61K31/438 ,  A61P1/04

CPC分类号： C07D471/10

摘要： The invention provides compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.

公开(公告)号：EP1824850A2

公开(公告)日：2007-08-29

申请号：EP05850438.2

申请日：2005-12-06

申请人： Nycomed GmbH

发明人： BREHM, Christof ,  BUHR, Wilm ,  CHIESA, M. Vittoria ,  PALMER, Andreas ,  ZIMMERMANN, Peter Jan ,  SIMON, Wolfgang-Alexander ,  POSTIUS, Stefan ,  KROMER, Wolfgang

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P1/04

CPC分类号： C07D471/04

摘要： The invention provides compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.

公开(公告)号：EP1926714A1

公开(公告)日：2008-06-04

申请号：EP06792891.1

申请日：2006-08-18

申请人： Nycomed GmbH

发明人： KOHL, Bernhard ,  ZIMMERMANN, Peter Jan ,  ZECH, Karl ,  ZIMMERMANN, Peter ,  BUHR, Wilm ,  PALMER, Andreas ,  BREHM, Christof ,  CHIESA, Maria Vittoria ,  DAVID, Michael ,  VON RICHTER, Oliver ,  SIMON, Wolfgang-Alexander ,  POSTIUS, Stefan ,  KROMER, Wolfgang ,  HOLST, Hans Christof

IPC分类号： C07D235/06 ,  C07D235/08 ,  C07D235/12 ,  A61K31/4184 ,  A61P1/04

CPC分类号： C07D235/12 ,  C07D235/06 ,  C07D235/08

摘要： The invention provides deuterated compounds of the formula (1), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.

公开(公告)号：EP1910313A1

公开(公告)日：2008-04-16

申请号：EP06725219.7

申请日：2006-03-22

申请人： Nycomed GmbH

发明人： ZIMMERMANN, Peter, Jan ,  BUHR, Wilm ,  BREHM, Christof ,  PALMER, Andreas ,  CHIESA, Maria Vittoria ,  SIMON, Wolfgang-Alexander ,  POSTIUS, Stefan ,  KROMER, Wolfgang

IPC分类号： C07D235/08 ,  A61K31/4184 ,  A61P1/04

CPC分类号： C07D235/06 ,  C07D235/08 ,  C07D235/12

摘要： The invention relates to (6)-thioamide-substituted benzimidazoles of formula (1), in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.

公开(公告)号：EP1879891A1

公开(公告)日：2008-01-23

申请号：EP06754865.1

申请日：2006-04-26

申请人： Nycomed GmbH

发明人： BREHM, Christof ,  KLEIN, Thomas ,  BUHR, Wilm ,  CHIESA, Maria, Vittoria ,  PALMER, Andreas ,  ZIMMERMANN, Peter, Jan ,  SIMON, Wolfgang-Alexander ,  KROMER, Wolfgang ,  POSTIUS, Stefan ,  GRUNDLER, Gerhard

IPC分类号： C07D471/04 ,  A61K31/4188 ,  A61P29/00 ,  A61P1/04

CPC分类号： C07D471/04

摘要： The invention relates compounds of the formula I, in which the substituents and symbols have the meanings as indicated in the description. The compounds are prodrugs and exhibit in the human and/or animal body antipyretic, analgesic, antiphlogistic and/or anti-inflammatory activity as well as gastric acid secretion inhibiting and therefore gastro and intestinal protective activity. Formula (I)

公开(公告)号：EP1899341A1

公开(公告)日：2008-03-19

申请号：EP06763685.2

申请日：2006-06-13

申请人： Nycomed GmbH

发明人： ZIMMERMANN, Peter Jan ,  SENN-BILFINGER, Jörg ,  BUHR, Wilm ,  BREHM, Christof ,  CHIESA, Maria Vittoria ,  PALMER, Andreas ,  SIMON, Wolfgang-Alexander ,  POSTIUS, Stefan ,  KROMER, Wolfgang

IPC分类号： C07D471/20 ,  A61K31/438 ,  A61P1/04

CPC分类号： C07D471/10

摘要： The invention provides compounds of the formula (I), in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.

公开(公告)号：EP1863820A1

公开(公告)日：2007-12-12

申请号：EP06725220.5

申请日：2006-03-22

申请人： Nycomed GmbH

发明人： CHIESA, Maria Vittoria ,  ZIMMERMANN, Peter Jan ,  BUHR, Wilm ,  BREHM, Christof ,  PALMER, Andreas ,  SIMON, Wolfgang-Alexander ,  KROMER, Wolfgang ,  POSTIUS, Stefan ,  HOLST, Hans Christof

IPC分类号： C07D491/04 ,  C07D471/04 ,  A61P1/00 ,  A61K31/4188

CPC分类号： C07D471/04 ,  C07D491/04

摘要： The invention relates to cyclic benzimidazoles of formula (I), in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.

公开(公告)号：EP1758900B1

公开(公告)日：2007-10-03

申请号：EP05752619.6

申请日：2005-06-07

申请人： Nycomed GmbH

发明人： BREHM, Christof ,  ZIMMERMANN, Peter Jan ,  BUHR, Wilm ,  CHIESA, M. Vittoria ,  PALMER, Andreas ,  POSTIUS, Stefan ,  KROMER, Wolfgang ,  SIMON, Wolfgang-Alexander

IPC分类号： C07D471/04 ,  A61K31/435

CPC分类号： C07D471/04

摘要： The invention relates to compounds of the formula (1), in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.