-
公开(公告)号：EP1907859B1
公开(公告)日：2011-03-02
申请号：EP06781626.4
申请日：2006-07-19
IPC分类号： G01N33/574 , C12Q1/48
CPC分类号： G01N33/57434 , A61K38/1709 , C07K14/4748 , C12Q1/48 , G01N33/573 , G01N2333/91051 , G01N2500/00
摘要： The present application provides novel human gene ELOVL7 whose expression is markedly elevated in prostate cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
-
公开(公告)号：EP2352825A1
公开(公告)日：2011-08-10
申请号：EP09809511.0
申请日：2009-08-21
IPC分类号： C12N15/09
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N33/57438 , G01N33/57484 , G01N2500/10
摘要： Objective methods for diagnosing a predisposition to developing pancreatic cancer and prostate cancer, particularly pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, are described herein. In one embodiment, the diagnostic method involves the step of determining an expression level of C12ORF48 using siRNAs targeting the C12ORF48 gene. The invention also features products such as siRNAs as well as to compositions containing them. The present invention further provides methods of screening for therapeutic agents useful in the treatment of C12ORF48 associated disease, such as a cancer, e.g. pancreatic cancer and prostate cancer, as well as methods of inhibiting the cell growth and treating or alleviating one or more disease symptoms. The invention also features products such as double stranded molecules, as well as vectors and compositions containing them.
-
公开(公告)号：EP2334790A1
公开(公告)日：2011-06-22
申请号：EP09809512.8
申请日：2009-08-21
CPC分类号： G01N33/57438 , C12N9/93 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/158 , C12Y603/02025
摘要： The present invention relates to the roles played by TTLL4 genes in pancreatic cancer carcinogenesis and features a method for treating or preventing pancreatic cancer by administering a double-stranded molecule against one or more of the TTLL4 genes or a composition, vector or cell containing such a double stranded molecule. Also, disclosed are methods of identifying compounds for treating and preventing pancreatic cancer, using as an index their effect on the over-expression of TTLL4 in the pancreatic cancer cell.
-
公开(公告)号：EP2262541A1
公开(公告)日：2010-12-22
申请号：EP09718793.4
申请日：2009-03-10
IPC分类号： A61K49/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , C07K16/18 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： G01N33/57438 , A61K48/005 , C07K16/303 , C12N15/113 , C12N2310/14 , G01N2500/02
摘要： Described herein are objective methods for detecting or diagnosing a predisposition to developing cancer, particularly pancreatic cancer. In one embodiment, the diagnostic method involves the step of determining an expression level of C2orf18 using anti-C2orf18 antibody. The present invention further provides methods of screening for therapeutic agents useful in the treatment of a C2orf18-associated disease, such as a cancer, e.g. pancreatic cancer, methods of inhibiting the cell growth and treating or alleviating their symptom. The invention also features products, such as polynucleotides, polypeptides, and vectors double-stranded molecules, antibodies, vectors and compositions composed thereof.
-
15.发明公开
公开(公告)号：EP2059593A2
公开(公告)日：2009-05-20
申请号：EP07792516.2
申请日：2007-08-08
IPC分类号： C12N15/11 , A61K31/7088 , A61K39/395 , C07K16/32 , C07K14/475 , A61K38/00 , A61P35/00 , C12Q1/68 , G01N33/53
CPC分类号： C12N15/1135 , A61K38/00 , C07K14/47 , C07K16/18 , C07K2317/56 , C07K2317/565 , C12N2310/111 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of an siRNA that inhibits expression of REG4 or KIAA0101. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, prostatic cancer cell, breast cancer cell, and bladder cancer cell, particularly pancreatic ductal adenocarcinoma (PDAC) by inhibiting REG4 gene. The present invention also relates to methods of treating or preventing PDAC in a subject comprising the step of administering to said subject a pharmaceutically effective amount of an antibody or fragment thereof that binds to a protein encoded by REG4. The present invention also relates to methods of diagnosing chemo-radiation therapeutic resistance of a cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises polypeptide which comprises QKGIGEFF/SEQ ID NO: 21. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine.
-
-
-
-
搜索结果
15 条记录 (耗时 0.028 秒)
