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1.发明授权DKK1 ONCOGENE AS THERAPEUTIC TARGET FOR CANCER AND A DIAGNOSING MARKER 有权DKK1-ONKOGEN ALS治疗ZIELFÜRKREBS UND诊断标记
公开(公告)号：EP2190478B1
公开(公告)日：2016-03-23
申请号：EP08790474.4
申请日：2008-08-21
IPC分类号： C07K16/32 , C12Q1/68 , C07K16/30 , G01N33/574 , A61K39/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/574 , G01N2333/4703 , G01N2500/04 , G01N2800/50
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公开(公告)号：EP1668156B9
公开(公告)日：2012-02-22
申请号：EP04773526.1
申请日：2004-09-24
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
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公开(公告)号：EP1668156B1
公开(公告)日：2011-05-04
申请号：EP04773526.1
申请日：2004-09-24
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
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公开(公告)号：EP1910570B1
公开(公告)日：2011-04-13
申请号：EP06782210.6
申请日：2006-07-26
IPC分类号： C12Q1/68
CPC分类号： C12N15/1137 , C12N15/1135 , C12N2310/14 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present application provides novel human gene GALNT6 whose expression is markedly elevated in breast cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of breast cancers, as target molecules for developing drugs against the disease, such as siRNAS, and for attenuating cell growth of breast cancer.
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5.发明公开
公开(公告)号：EP2190478A1
公开(公告)日：2010-06-02
申请号：EP08790474.4
申请日：2008-08-21
IPC分类号： A61K39/395 , A61P35/00 , G01N33/15 , G01N33/50
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/574 , G01N2333/4703 , G01N2500/04 , G01N2800/50
摘要： Described herein are antibodies and antibody fragments capable of treating or preventing cancers associated with the over-expression and/or up-regulation of DKK1. Also disclosed are methods of treating or preventing cancer using the antibody and methods and kits utilized to diagnosing cancer. The herein described products and methods find utility in the context of a variety of cancers, such as pancreatic cancer, gastric cancer, liver cancer, prostate cancer, breast cancer, cervical cancer, bile duct cancer, lung cancer and esophageal cancer.
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6.发明公开SCREENING AND THERAPEUTIC METHOD FOR NSCLC TARGETING THE CDCA8-AURKB COMPLEX 审中-公开检测和治疗靶点程序非小细胞肺癌CDCA8，AURKB COMPLEX为目的地
公开(公告)号：EP2142648A1
公开(公告)日：2010-01-13
申请号：EP08739764.2
申请日：2008-03-27
IPC分类号： C12N15/09 , A61K47/46 , A61P35/00 , G01N33/574
CPC分类号： G01N33/57423 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12Y207/01037 , G01N33/5044 , G01N2500/02 , G01N2500/10
摘要： The present invention is based on the observation that the co-activation of CDCA8 and AURKB, and their cognate interactions, play a significant role in lung-cancer progression. Accordingly, inhibiting the formation of the CDCA8-AURKB complex finds utility in the treatment of non-small-cell lung cancer. The present invention also provides methods for identifying for compounds suitable for the treatment and/or prevention non-small-cell lung cancer, using, for example, the transcriptional regulatory region of the CDCA8 or AURKB gene, as well as diagnostic and prognostic methods that utilize the expression levels of CDCA8 and/or AURKB as a determining index.
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公开(公告)号：EP1727831A1
公开(公告)日：2006-12-06
申请号：EP05721047.8
申请日：2005-03-11
IPC分类号： C07K14/47 , G01N33/574 , C12Q1/68 , C12N15/63 , C12N15/11 , C07K16/18 , A61K38/17 , C12N5/10
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5011 , G01N33/57434
摘要： The present application provides novel human gene CCDC4 whose expression is markedly elevated in prostate cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
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公开(公告)号：EP1668156A2
公开(公告)日：2006-06-14
申请号：EP04773526.1
申请日：2004-09-24
CPC分类号： C12Q1/6886 , C07K14/4702 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/57415 , G01N2500/04
摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates between BRC cells and normal cells. In another embodiment, the diagnostic method involves determining the expression level of a BRC-associated gene that discriminates among BRC cells, between DCIS and IDC cells. The present invention further provides means for predicting and preventing breast cancer metastasis using BRC-associated genes having unique altered expression patterns in breast cancer cells with lymph-node metastasis. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of breast cancer, methods of treating breast cancer and method for vaccinating a subject against breast cancer.
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9.发明授权
公开(公告)号：EP1855707B1
公开(公告)日：2012-04-04
申请号：EP06714491.5
申请日：2006-02-17
摘要： The present invention provides immunogenic peptides comprising the amino acid sequence of SEQ ID NO: 1, 2, 13, 32, and peptides comprising the above-mentioned amino acid sequences in which 1, 2, or several amino acids are substituted or added, and having cytotoxic T cell inducibility, and also provides drugs for treating or preventing tumors comprising these peptides. The peptides of this invention can be used as vaccines.
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公开(公告)号：EP1907859B1
公开(公告)日：2011-03-02
申请号：EP06781626.4
申请日：2006-07-19
IPC分类号： G01N33/574 , C12Q1/48
CPC分类号： G01N33/57434 , A61K38/1709 , C07K14/4748 , C12Q1/48 , G01N33/573 , G01N2333/91051 , G01N2500/00
摘要： The present application provides novel human gene ELOVL7 whose expression is markedly elevated in prostate cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
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