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公开(公告)号：EP2076506B1
公开(公告)日：2010-09-22
申请号：EP08727696.0
申请日：2008-01-15
IPC分类号： C07D401/04 , C07D451/14 , C07D471/04 , C07D471/08 , A61K31/498 , A61P25/04
CPC分类号： C07D401/04 , C07D451/14 , C07D471/04 , C07D471/08
摘要： The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.
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公开(公告)号：EP2164325A1
公开(公告)日：2010-03-24
申请号：EP08767992.4
申请日：2008-05-30
申请人： Shionogi&Co., Ltd.
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D211/96
摘要： The invention relates to oxyimino compounds of (Formula I), and pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein: Y is CO or SOm; Z is hydrogen, each optionally substituted lower alkyl, lower alkenyl, aryl, heterocyclyl etc. R1 and R2 are each independently hydrogen, each optionally substituted lower alkyl, lower alkenyl, cycloalkyl, aryl, heterocyclyl etc., each X is independently =O, optionally substituted lower alkyl, cyano, nitro etc., m is 1 or 2, p is O, 1 or 2 and q is O or 1. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及（式I）的氧亚氨基化合物及其药学上可接受的盐，前药和溶剂化物，其中：Y是CO或SOm; Z为氢，各自任选取代的低级烷基，低级烯基，芳基，杂环基等.R 1和R 2各自独立地为氢，各自任选取代的低级烷基，低级烯基，环烷基，芳基，杂环基等，各X独立地为= O， 任选取代的低级烷基，氰基，硝基等，m是1或2，p是0,1或2，q是0或1.本发明还涉及使用式I化合物治疗，预防或改善 对钙通道阻断有响应的病症，特别是N型钙通道。 本发明的化合物对于治疗疼痛特别有用。
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公开(公告)号：EP2040698A2
公开(公告)日：2009-04-01
申请号：EP07810356.1
申请日：2007-07-12
发明人： MATSUMURA, Akira , MIKAMIYAMA, Hidenori , TSUNO, Naoki , KYLE, Donald, J. , SHAO, Bin , YAO, Jiangchao
IPC分类号： A61K31/40 , C07D207/14
CPC分类号： C07D211/72 , C07D211/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is O, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
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14.发明公开SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF 审中-公开PIPERIDINVERBINDUNGEN VOM SUBSTITUIERTEN CHINOXALINTYP UND ANWENDUNGEN DAVON
公开(公告)号：EP3101018A1
公开(公告)日：2016-12-07
申请号：EP16176601.9
申请日：2008-08-29
发明人： GOEHRING, R. Richard , MATSUMURA, Akira , SHAO, Bin , TAODA, Yoshiyuki , TSUNO, Naoki , WHITEHEAD, John, W., F. , YAO, Jiangchao , FUCHINO, Kouki
IPC分类号： C07D401/04 , C07D401/14 , C07D451/04 , C07D451/14 , C07D471/14 , A61K31/498 , A61K31/4985 , A61P25/04
CPC分类号： C07D451/14 , A61K31/498 , C07D401/04 , C07D401/14 , C07D451/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D498/08 , C07D519/00
摘要： The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds of formula (I) and formula (II), compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.
摘要翻译： 本发明涉及式（I）和式（II）的取代的喹喔啉型哌啶化合物，包含有效量的取代的喹喔啉型哌啶化合物的组合物和治疗或预防诸如疼痛的病症的方法，包括 向有需要的动物施用有效量的取代的喹喔啉型哌啶化合物。
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公开(公告)号：EP2164325B1
公开(公告)日：2013-04-24
申请号：EP08767992.4
申请日：2008-05-30
申请人： Shionogi & Co., Ltd.
IPC分类号： A01N43/40 , A61K31/445 , A61P25/00
CPC分类号： C07D211/96
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公开(公告)号：EP2076506A2
公开(公告)日：2009-07-08
申请号：EP08727696.0
申请日：2008-01-15
IPC分类号： C07D401/04 , C07D451/14 , C07D471/04 , C07D471/08 , A61K31/498 , A61P25/04
CPC分类号： C07D401/04 , C07D451/14 , C07D471/04 , C07D471/08
摘要： The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound.
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