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公开(公告)号：EP2040698A2
公开(公告)日：2009-04-01
申请号：EP07810356.1
申请日：2007-07-12
发明人： MATSUMURA, Akira , MIKAMIYAMA, Hidenori , TSUNO, Naoki , KYLE, Donald, J. , SHAO, Bin , YAO, Jiangchao
IPC分类号： A61K31/40 , C07D207/14
CPC分类号： C07D211/72 , C07D211/96 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is O, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
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2.发明授权ARYL SUBSTITUTED PYRIDINES, PYRIMIDINES, PYRAZINES AND TRIAZINES AND THE USE THEREOF 有权芳基取代的吡啶，嘧啶，吡嗪和三嗪及其使用
公开(公告)号：EP1265866B1
公开(公告)日：2010-07-21
申请号：EP01918558.6
申请日：2001-03-12
申请人： Euro-Celtique S.A.
发明人： HOGENKAMP, Derk, J. , NGUYEN, Phong , SHAO, Bin
IPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D251/24 , C07D241/24 , C07D403/04 , A61K31/505 , A61P25/08
CPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D241/24 , C07D251/24 , C07D403/04
摘要： This invention relates aryl substituted pyridines, pyrimides, pyrazines and triazines of Formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhytmics and for the treatment of prevention of diabetic neuropathy.
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3.发明公开HETEROCYCLIC SUBSTITUTED 2- (4-PHENOXY) PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEURONAL DAMAGE AND NEURODEGENERATIVE CONDITIONS 审中-公开杂环取代的2-（4-苯氧基）吡啶衍生物和相关化合物作为钠通道阻滞剂用于治疗神经元损伤和神经变性疾病
公开(公告)号：EP1432424A1
公开(公告)日：2004-06-30
申请号：EP02770470.9
申请日：2002-09-06
申请人： Euro-Celtique S.A.
发明人： SHAO, Bin , GOEHRING, R., Richard
IPC分类号： A61K31/5377 , A61K31/4545 , C07D413/04 , C07D213/68 , C07D213/74 , C07D213/79 , C07D213/81
CPC分类号： C07D213/64 , C07D213/81
摘要： This invention relates to aryl substituted pyridines of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: Ar is selected from the group consisting of Ar1, Ar2, Ar3 and Ar4, wherein Ar1 is R1 is selected from the group consisting of an optionally substituted alkyl, amino, alkylthiol, C(O)R10, SO2R10, and OC(O)NH2; R2 is Ym-(CH2)n-Z, wherein Y is O, S or NR11, wherein R11 is hydrogen or alkyl, Z is a saturated heterocyclic ring optionally substituted at one or more carbon atoms, m is 0 or 1, and n is 0-6; or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyothrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, including diabetic neuropathy, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, and as antiarrhythmics.
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4.发明授权
公开(公告)号：EP1242085B1
公开(公告)日：2005-08-24
申请号：EP00980981.5
申请日：2000-12-06
申请人： Euro-Celtique, S.A.
发明人： KYLE, Donald , GOEHRING, Richard, R. , SHAO, Bin
IPC分类号： C07D401/04 , A61K31/4184 , A61P25/04
CPC分类号： C07D401/04
摘要： Disclosed are compounds of formula (I), wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
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5.发明公开ARYL SUBSTITUTED PYRIDINES, PYRIMIDINES, PYRAZINES AND TRIAZINES AND THE USE THEREOF 有权芳基取代的吡啶，嘧啶，吡嗪和三嗪及其使用
公开(公告)号：EP1265866A2
公开(公告)日：2002-12-18
申请号：EP01918558.6
申请日：2001-03-12
发明人： HOGENKAMP, Derk, J. , NGUYEN, Phong , SHAO, Bin
IPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D251/24 , C07D241/24 , C07D403/04 , A61K31/505 , A61P25/08
CPC分类号： C07D213/81 , C07D239/28 , C07D239/38 , C07D241/24 , C07D251/24 , C07D403/04
摘要： This invention relates aryl substituted pyridines, pyrimides, pyrazines and triazines of Formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhytmics and for the treatment of prevention of diabetic neuropathy.
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6.发明公开ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS 审中-公开芳基取代的吡啶甲酰胺及其作为钠通道阻滞剂
公开(公告)号：EP1432419A1
公开(公告)日：2004-06-30
申请号：EP02773292.4
申请日：2002-09-06
申请人： Euro-Celtique S.A.
IPC分类号： A61K31/4418 , C07D213/82 , C07D213/81 , A61P23/00 , A61P25/08 , A61P9/06
CPC分类号： C07D213/81 , C07D213/82 , Y10T436/145555
摘要： This invention relates aryl substituted pyridines of Formula (I),or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1-R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
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公开(公告)号：EP1242085A1
公开(公告)日：2002-09-25
申请号：EP00980981.5
申请日：2000-12-06
申请人： Euro-Celtique, S.A.
发明人： KYLE, Donald , GOEHRING, Richard, R. , SHAO, Bin
IPC分类号： A61K31/454 , A61P29/02 , C07D401/04
CPC分类号： C07D401/04
摘要： Disclosed are compounds of formula (I), wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
摘要翻译： 公开了式（I）的化合物，其中A，R 1，R 2，R 3，R 4和X 1如本文所公开。 这些化合物对ORL1受体具有亲和力，可用于治疗慢性和急性疼痛。
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公开(公告)号：EP1711484A1
公开(公告)日：2006-10-18
申请号：EP05726385.7
申请日：2005-02-02
申请人： EURO-CELTIQUE S.A.
IPC分类号： C07D401/04 , C07D221/00
CPC分类号： C07D471/10 , C07D401/04
摘要： Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
摘要翻译： 在某些实施方案中公开了合成式（V）化合物及其盐的方法。
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9.发明授权
公开(公告)号：EP2086958B1
公开(公告)日：2015-01-14
申请号：EP08806986.9
申请日：2008-08-29
发明人： GOEHRING, Richard, R. , MATSUMURA, Akira , SHAO, Bin , TAODA, Yoshiyuki , TSUNO, Naoki , WHITEHEAD, John, William, Frank , YAO, Jiangchao , FUCHINO, Kouki
IPC分类号： C07D401/04 , C07D401/14 , C07D451/04 , C07D451/14 , C07D471/14 , A61K31/498 , A61K31/4985 , A61P25/04
CPC分类号： C07D451/14 , A61K31/498 , C07D401/04 , C07D401/14 , C07D451/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D498/08 , C07D519/00
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10.发明授权TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF 有权四氢吡啶和DIHYDROPYRROLYLVERBINDUNGEN及其用途
公开(公告)号：EP2331522B1
公开(公告)日：2013-09-18
申请号：EP09802045.6
申请日：2009-08-03
发明人： MIKAMIYAMA, Hidenori , NI, Chiyou , SHAO, Bin , TAFESSE, Laykea
IPC分类号： C07D401/04 , C07D413/14 , C07D409/14 , C07D401/14 , C07D413/04 , C07D451/02 , A61K31/44 , A61P25/28 , A61P25/04
CPC分类号： C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D451/02
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