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21 条记录 (耗时 0.019 秒)

    CHARGED MASS LABELING SYSTEM
    11.
    发明公开
    CHARGED MASS LABELING SYSTEM 审中-公开

    公开(公告)号：EP3405783A1

    公开(公告)日：2018-11-28

    申请号：EP17742004.9

    申请日：2017-01-20

    申请人： Purdue Research Foundation

    发明人： COOKS, Robert, Graham ,  BAIRD, Zane ,  PUGIA, Michael ,  HOLLERBACH, Adam ,  AYRTON, Stephen

    IPC分类号： G01N30/72 ,  G01N33/68

    CPC分类号： G01N33/6848 ,  G01N33/68

    摘要： The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

    LINEAR ION TRAP WITH FOUR PLANAR ELECTRODES
    14.
    发明公开
    LINEAR ION TRAP WITH FOUR PLANAR ELECTRODES 审中-公开
    WITH四个平面电极线性离子阱

    公开(公告)号：EP1849177A2

    公开(公告)日：2007-10-31

    申请号：EP06734407.7

    申请日：2006-02-07

    申请人： Purdue Research Foundation

    发明人： SONG, Yishu ,  OUYANG, Zheng ,  COOKS, Robert, Graham ,  WU, Guangxiang

    IPC分类号： H01J49/42 ,  B01D59/44

    CPC分类号： H01J49/422

    摘要： A rectilinear ion trap includes a first pair of spaced planar RF electrodes, mounted in parallel and a second pair of spaced planar electrodes, mounted in parallel and orthogonal to the first pair of electrodes. The configuration of the pairs of electrodes define an axial direction and a radial direction. The trap further includes an RF source that applies an RF voltage to at least one of the pairs of RF electrodes to generate RF fields to trap ions in the axial and radial directions.

    METHOD AND SYSTEM FOR DESORPTION ELECTROSPRAY IONIZATION
    15.
    发明公开
    METHOD AND SYSTEM FOR DESORPTION ELECTROSPRAY IONIZATION 有权
    方法和系统解吸 - 电喷雾电离

    公开(公告)号：EP1741120A2

    公开(公告)日：2007-01-10

    申请号：EP05763710.0

    申请日：2005-03-30

    申请人： Purdue Research Foundation

    发明人： TAKÁTS, Zoltán ,  GOLOGAN, Bogdan ,  WISEMAN, Justin, Michael ,  COOKS, Robert, Graham

    IPC分类号： H01J27/00

    CPC分类号： H01J49/142 ,  H01J49/0004 ,  H01J49/0404

    摘要： A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.

    USE OF A CHARGED MASS LABELING SYSTEM FOR THE DETECTION OF TARGET ANALYTES
    16.
    发明公开
    USE OF A CHARGED MASS LABELING SYSTEM FOR THE DETECTION OF TARGET ANALYTES 审中-公开

    公开(公告)号：EP4012416A1

    公开(公告)日：2022-06-15

    申请号：EP22155363.9

    申请日：2017-01-20

    申请人： Purdue Research Foundation

    发明人： COOKS, Robert, Graham ,  BAIRD, Zane ,  PUGIA, Michael ,  HOLLERBACH, Adam ,  AYRTON, Stephen

    IPC分类号： G01N33/68 ,  G01N33/531 ,  G01N33/574 ,  C12Q1/6872

    摘要： The present invention provides a method for detecting a target analyte in a sample, the method comprising:
    introducing a charged mass label composition to a sample comprising a target analyte, wherein the charged mass label composition comprises an affinity reagent; and a mass label precursor bound to the affinity reagent, wherein the mass label precursor comprises a label binding unit and a mass label, the label binding unit reversibly binding the mass label to the affinity reagent, and wherein the mass label comprises a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum;
    incubating the sample and the charged mass label composition so that the charged mass label composition binds the target analyte via an interaction between the affinity reagent of the charged mass label composition and the target analyte;
    releasing the mass label from the affinity reagent by breaking one or more bonds of the label binding unit;
    ionizing the mass label; and
    detecting the ionized mass label and/or fragments thereof in a mass spectrometer, thereby detecting the target analyte in the sample.

    ENCLOSED DESORPTION ELECTROSPRAY IONIZATION
    20.
    发明公开
    ENCLOSED DESORPTION ELECTROSPRAY IONIZATION 审中-公开
    解吸包 - 电喷雾

    公开(公告)号：EP2122661A1

    公开(公告)日：2009-11-25

    申请号：EP07868088.1

    申请日：2007-12-28

    申请人： Purdue Research Foundation

    发明人： VENTER, Andre ,  COOKS, Robert, Graham

    IPC分类号： H01J49/16

    CPC分类号： H01J49/165 ,  H01J49/142

    摘要： An improvement to Desorption Electrospray Ionization (DESI), the process of creating ions directly from sample surfaces for mass spectrometric (MS) analysis by impinging a liquid spray onto the surface. The improvement is brought about by enclosing the spray and sample surface and MS-inlet capillary in a pressure tight enclosure. The invention includes methods of sampling a larger or smaller area of surface by impacting and collecting droplets from such an area. The invention allows DESI to be performed without need for careful control of the geometry of the sprayer and MS-inlet capillary positions and angles relative to the sample surface.