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公开(公告)号：EP2603530A2
公开(公告)日：2013-06-19
申请号：EP11740932.6
申请日：2011-08-09
申请人： Roche Glycart AG
发明人： BACAC, Marina , FREIMOSER-GRUNDSCHOBER, Anne , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , NICOLINI, Valeria G. , UMANA, Pablo
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K47/6871 , A61K51/1075 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/41 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/92
摘要： The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
摘要翻译： 本发明提供了针对成纤维细胞活化蛋白（FAP），并使用它们的方法的抗体。
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公开(公告)号：EP2516469A1
公开(公告)日：2012-10-31
申请号：EP10798541.8
申请日：2010-12-17
申请人： Roche Glycart AG
发明人： BOSSENMAIER, Birgit , DIMOUDIS, Nikolaos , FRIESS, Thomas , GEORGES, Guy , KOLM, Irene , KRELL, Hans-Willi , LIFKE, Valeria , MOESSNER, Ekkehard
IPC分类号： C07K16/28 , C07K16/32 , A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies binding to human HER3 (anti-HER3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：EP2417156A1
公开(公告)日：2012-02-15
申请号：EP10712365.5
申请日：2010-04-01
申请人： Roche Glycart AG
发明人： BRINKMANN, Ulrich , CROASDALE, Rebecca , HOFFMANN, Eike , KLEIN, Christian , MOESSNER, Ekkehard , SCHANZER, Juergen Michael , UMANA, Pablo , SUSTMANN, Claudio
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
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公开(公告)号：EP2331575A1
公开(公告)日：2011-06-15
申请号：EP09815646.6
申请日：2009-09-21
申请人： Roche Glycart AG
发明人： AUER, Johannes , DIMOUDIS, Nikolaos , GEORGES, Guy , HANKE, Petra , KNOETGEN, Hendrik , LANGRISH, Claire, Louise , MOESSNER, Ekkehard
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , C07K2317/76 , Y10S530/809
摘要： An antibody binding to IL- 17 characterized by binding to the same IL- 17 epitope to which monoclonal antibody 3C1 binds, and being of human IgG1 isotype modified in the hinge region at amino acid position 216-240, preferably at amino acid position 220-240, between C
H 1 and C
H 2 and/or in the second inter-domain region at amino acid position 327-331 between C
H 2 and C
H 3 has advantageous properties for the treatment of inflammatory diseases.-
公开(公告)号：EP3892640A1
公开(公告)日：2021-10-13
申请号：EP20217556.8
申请日：2012-08-21
申请人： Roche Glycart AG
发明人： AST, Oliver , BRUENKER, Peter , FAUTI, Tanja , FREIMOSER-GRUNDSCHOBER, Anne , JAEGER, Christiane , KLEIN, Christian , MOESSNER, Ekkehard , UMAÑA, Pablo
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：EP3489255A1
公开(公告)日：2019-05-29
申请号：EP18191941.6
申请日：2012-02-07
申请人： Roche Glycart AG
发明人： AST, Oliver , BRUENKER, Peter , FREIMOSER-GRUNDSCHOBER, Anne , HERTER, Sylvia , HOFER, Thomas U. , HOSSE, Ralf , KLEIN, Christian , MOESSNER, Ekkehard , NICOLINI, Valeria G. , UMANA, Pablo
IPC分类号： C07K14/55 , C12N15/26 , A61K39/395 , C07K16/46 , C07K19/00 , C07K14/54 , A61K38/20 , C07K16/28 , C07K16/30 , C07K16/40 , A61K39/00 , A61K47/68
摘要： The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the α-subunit of the IL-2 receptor, for use as immunotherapeutic agents. In addition, the invention relates to immunoconjugates comprising said mutant IL-2 polypeptides, polynucleotide molecules encoding the mutant IL-2 polypeptides or immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant IL-2 polypeptides or immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：EP2882774B1
公开(公告)日：2018-10-03
申请号：EP13745407.0
申请日：2013-08-05
申请人： Roche Glycart AG
发明人： DUERNER, Lydia Jasmin , EMRICH, Thomas , FISCHER, Jens , HOSSE, Ralf , MOESSNER, Ekkehard , UMANA, Pablo , XU, Daigen
CPC分类号： C07K16/00 , A61K38/00 , A61K39/00 , C07K14/5428 , C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/92 , C07K2319/00
摘要： The present invention generally relates to fusion proteins of antibodies and interleukin-10 (IL-10). In addition, the present invention relates to polynucleotides encoding such fusion proteins, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the fusion proteins of the invention, and to methods of using them in the treatment of disease.
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公开(公告)号：EP3321286A1
公开(公告)日：2018-05-16
申请号：EP17206703.5
申请日：2012-08-21
申请人： Roche Glycart AG
发明人： AST, Oliver , BRUENKER, Peter , FAUTI, Tanja , FREIMOSER-GRUNDSCHOBER, Anne , NEUMANN, Christiane , KLEIN, Christian , MOESSNER, Ekkehard , UMANA, Pablo
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00
CPC分类号： C07K16/468 , C07K16/2809 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/40 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
摘要翻译： 本发明一般涉及用于T细胞活化和重定向至特定靶细胞的新型双特异性抗原结合分子。 此外，本发明涉及编码此类双特异性抗原结合分子的多核苷酸，以及包含此类多核苷酸的载体和宿主细胞。 本发明进一步涉及生产本发明双特异性抗原结合分子的方法，以及使用这些双特异性抗原结合分子治疗疾病的方法。
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公开(公告)号：EP2961770A1
公开(公告)日：2016-01-06
申请号：EP14705788.9
申请日：2014-02-24
申请人： Roche Glycart AG
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61K35/00 , C07K16/46
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/2863 , C07K16/3007 , C07K16/3053 , C07K16/468 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/66 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present disclosure generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present disclosure relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The disclosure further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：EP2467165B1
公开(公告)日：2015-01-07
申请号：EP10744911.8
申请日：2010-08-13
申请人： Roche Glycart AG
CPC分类号： C07K16/00 , A61K47/48423 , A61K47/48538 , A61K47/48646 , A61K47/6813 , A61K47/6843 , A61K47/6871 , A61K2039/505 , C07K16/18 , C07K16/40 , C07K16/468 , C07K2317/73 , C07K2317/74 , C07K2317/92
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