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公开(公告)号：EP3156424A4
公开(公告)日：2018-01-24
申请号：EP15799360
申请日：2015-05-27
发明人： KIM YONG ZU , PARK TAE KYO , WOO SUNG HO , KIM SUN YOUNG , CHO JONG UN , JUNG DOO HWAN , YANG JEON , MIN JI YOUNG , LEE HYANG SOOK , PARK YUN HEE , RYU JEONG HEE , OH KYU MAN , OH YEONG SOO , CHAE JEIWOOK , SONG HO YOUNG , CHUNG CHUL-WOONG
CPC分类号： A61K47/48715 , A61K47/48 , A61K47/48092 , A61K47/48338 , A61K47/48384 , A61K47/48415 , A61K47/48584 , A61K47/48646 , A61K47/549 , A61K47/6803 , A61K47/6855 , A61K47/6889 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：EP3229846A1
公开(公告)日：2017-10-18
申请号：EP15866409.4
申请日：2015-12-08
发明人： ZHU, Tong , CHEN, Gang , FU, Yanwen , GROS, Edwige
CPC分类号： C07K16/40 , A61K47/48407 , A61K47/48438 , A61K47/48646 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K2039/505 , C07K16/2863
摘要： There is disclosed an antibody drug conjugate (ADC) having an IgG antibody that binds to a c-Met target conjugated at both Cys sites in the hinge region of an IgG antibody. There is further disclosed a method for treating a breast cancer comprising providing an effective amount of a c-Met ADC.
摘要翻译： 公开了具有IgG抗体的抗体药物偶联物（ADC），其结合IgG抗体的铰链区的两个Cys位点处缀合的c-Met靶标。 还公开了治疗乳腺癌的方法，包括提供有效量的c-Met ADC。
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3.发明公开PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF 有权PICOLINAT-QUERVERBRÜCKTECYCLAME，CHELATE MIT METALLISCHEN KATIONEN UND VERWENDUNG DAVON
公开(公告)号：EP3068787A1
公开(公告)日：2016-09-21
申请号：EP14799724.1
申请日：2014-11-12
发明人： TRIPIER, Raphaël , HALIME, Zakaria
IPC分类号： C07D487/08 , A61K47/22 , A61K47/48 , A61K51/04
CPC分类号： A61K51/1075 , A61K47/48384 , A61K47/48646 , A61K47/6803 , A61K47/6871 , A61K51/0482 , A61K51/1093 , C07B59/002 , C07B2200/05 , C07D487/08 , C07K16/32 , C07K2317/24
摘要： The present invention relates to chelates resulting from the complexation of picolinate cross-bridged cyclams of formula (I), wherein n and the substituents L1-L4 and R1-R5 are defined as in the claims, with metallic cations. The invention further relates to picolinate cross-bridged cyclam ligands of formula (I). Another object of the invention is the use of chelates of the invention in nuclear medicine and the use of ligands of the invention in cations detection or epuration of effluents.
摘要翻译： 本发明涉及由式（I）的吡啶甲酸酯交联桥环化合物络合而得到的螯合物，其中取代基L1-L4和R1-R4如权利要求中所定义，与金属阳离子形成。 本发明还涉及式（I）的吡啶甲酰交叉桥环胞酰胺配体。 本发明的另一个目的是使用本发明的螯合物在核医学中的用途，以及使用本发明的配体在阳离子检测或流出液中的成熟。
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4.发明公开
公开(公告)号：EP3019202A1
公开(公告)日：2016-05-18
申请号：EP14745210.6
申请日：2014-07-11
IPC分类号： A61K47/48 , C07K16/30 , C07D207/456
CPC分类号： A61K47/48646 , A61K47/48338 , A61K47/48561 , A61K47/48715 , A61K47/65 , A61K47/6849 , A61K47/6871 , A61K47/6889 , A61K49/00 , A61K51/02 , C07D207/456 , C07K16/2887 , C07K16/32 , C07K16/40 , C12N9/1077 , C12N9/24 , C12N9/2497 , C12Y204/02036 , C12Y302/00 , C12Y302/02022
摘要： The present invention concerns novel antibody-drug conjugates and the use of same in therapy, in particular in anti-cancer or anti-inflammatory therapy. The present invention also concerns useful synthesis products as linkers, consisting of a linker head and a linker body. The present invention also concerns a method for preparing the linkers and antibody-drug conjugates.
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5.发明授权PICOLINATE CROSS-BRIDGED CYCLAMS, CHELATES WITH METALLIC CATIONS AND USE THEREOF 有权PICOLINATE具有金属阳离子的螯合环，以及使用它们的用途
公开(公告)号：EP3068787B1
公开(公告)日：2017-11-01
申请号：EP14799724.1
申请日：2014-11-12
发明人： TRIPIER, Raphaël , HALIME, Zakaria
IPC分类号： A61K31/4427 , A61P35/04
CPC分类号： A61K51/1075 , A61K47/48384 , A61K47/48646 , A61K47/6803 , A61K47/6871 , A61K51/0482 , A61K51/1093 , C07B59/002 , C07B2200/05 , C07D487/08 , C07K16/32 , C07K2317/24
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6.发明公开METHODS OF TREATING EARLY BREAST CANCER WITH TRASTUZUMAB-MCC-DM1 AND PERTUZUMAB 审中-公开VERFAHREN ZUR BEHANDLUNG VONFRÜHZEITIGEMBRUSTKREBS MIT TRASTUZUMAB-MCC-DM1 UND PERUUZUMAB
公开(公告)号：EP3134440A1
公开(公告)日：2017-03-01
申请号：EP15720875.2
申请日：2015-04-23
CPC分类号： A61K47/48646 , A61K31/513 , A61K31/5365 , A61K31/675 , A61K31/704 , A61K39/395 , A61K39/39558 , A61K47/6803 , A61K47/6855 , A61K47/6869 , A61K47/6871 , A61K2039/507 , C07K16/32 , C07K2317/24 , C07K2317/72 , A61K2300/00
摘要： Methods of treating patients having HER2 -positive, operable, locally advanced or inflammatory breast cancer with the antibody-drug conjugate Trastuzumab-MCC-DMl and Pertuzumab are provided.
摘要翻译： 提供了使用抗体 - 药物缀合物曲妥单抗-MMC-DM1和Pertuzumab治疗患有HER2阳性，可操作的，局部晚期或炎性乳腺癌的患者的方法。
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7.发明公开NOVEL ANTI-RNF43 ANTIBODIES AND METHODS OF USE 审中-公开VERFAHREN ZUR VERWENDUNG的NEUARTIGE ANTI-RNF43-ANTIKÖRPER
公开(公告)号：EP3134121A2
公开(公告)日：2017-03-01
申请号：EP15783044.9
申请日：2015-04-21
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/40 , A61K47/48646 , A61K47/6857 , A61K47/6863 , A61K47/6871 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The invention discloses novel anti-RNF43 antibodies and derivatives thereof, including antibody drug conjugates, and methods of using such anti-RNF43 antibodies and antibody drug conjugates to diagnose and treat cancer.
摘要翻译： 本发明公开了新型抗RNF43抗体及其衍生物，包括抗体药物偶联物，以及使用这种抗RNF43抗体和抗体药物偶联物来诊断和治疗癌症的方法。
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8.发明公开SPECIFIC DELIVERY OF TOXINS CONJUGATED WTIH ANTIBODIES TO ACTIVATED MATRIPTASE 审中-公开反对资本蛋白裂解酶共轭毒素的抗体靶向释放
公开(公告)号：EP2904015A1
公开(公告)日：2015-08-12
申请号：EP13844164.7
申请日：2013-10-02
CPC分类号： A61K47/48646 , A61K31/704 , A61K31/7048 , A61K47/6809 , A61K47/6851 , A61K47/6871 , C07K16/40 , C07K2317/24 , C07K2317/76 , C07K2319/55
摘要： Disclosed are antibody drug conjugates (ADC) that include highly potent toxic agents with specific antibodies to target tumors. Also disclosed are related antibodies, polypeptides, nucleic acids, host cells, compositions, and uses.
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公开(公告)号：EP3096797A1
公开(公告)日：2016-11-30
申请号：EP15703385.3
申请日：2015-01-23
CPC分类号： A61K47/48646 , A61K38/08 , A61K47/6811 , A61K47/6819 , A61K47/6869 , A61K47/6871 , A61K47/6889 , C07K16/40
摘要： Provided herein are methods of treating prostate cancer in particular androgen receptor inhibitor nave prostate cancer using anti-STEAP-1 antibodies and immunoconjugates thereof.
摘要翻译： 本文提供了使用抗STEAP-1抗体及其免疫偶联物治疗前列腺癌特别是雄激素受体抑制剂前列腺癌的方法。
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10.发明授权Picolinate cross-bridged cyclams, chelates with metallic cations and use thereof 有权Picolinatcyclame跨桥，螯合物与金属阳离子和它们的使用
公开(公告)号：EP2871186B1
公开(公告)日：2016-09-21
申请号：EP13192597.6
申请日：2013-11-12
发明人： Tripier, Raphaël , Halime, Zakaria
IPC分类号： C07D487/08 , A61K47/22 , A61K47/48 , A61K51/04
CPC分类号： A61K51/1075 , A61K47/48384 , A61K47/48646 , A61K47/6803 , A61K47/6871 , A61K51/0482 , A61K51/1093 , C07B59/002 , C07B2200/05 , C07D487/08 , C07K16/32 , C07K2317/24
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