公开(公告)号：EP4257193A3

公开(公告)日：2024-01-24

申请号：EP23179697.0

申请日：2017-04-13

申请人： Sanofi

发明人： YANG, Zhi-Yong ,  LANGE, Christian ,  CORVEY, Carsten ,  NABEL, Gary J. ,  WU, Lan ,  SEUNG, Edward ,  WEI, Ronnie ,  BENINGA, Jochen ,  RAO, Ercole ,  LEUSCHNER, Wulf Dirk ,  BEIL, Christian

IPC分类号： C07K16/24 ,  C07K16/28 ,  C07K16/32 ,  A61P35/00 ,  A61P29/00 ,  A61K39/00 ,  C07K16/46

摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.