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公开(公告)号：EP4257193A3
公开(公告)日：2024-01-24
申请号：EP23179697.0
申请日：2017-04-13
申请人： Sanofi
发明人： YANG, Zhi-Yong , LANGE, Christian , CORVEY, Carsten , NABEL, Gary J. , WU, Lan , SEUNG, Edward , WEI, Ronnie , BENINGA, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian
摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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2.发明公开DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION 审中-公开抗体结合带双可变区相关蛋白及结合区域交叉对准
公开(公告)号：EP3112380A1
公开(公告)日：2017-01-04
申请号：EP16169620.8
申请日：2012-03-28
申请人： SANOFI
发明人： BAURIN, Nicolas , BEIL, Christian , CORVEY, Carsten , LANGE, Christian , LI, Danxi , MIKOL, Vincent , STEINMETZ, Anke , RAO, Ercole
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
摘要翻译： 本发明提供了抗体样结合蛋白包含四个多肽链没有形成四个抗原结合位点，worin每对多肽形成抗体样结合蛋白的具有具有交叉定向双重可变结构域。 因此本发明提供用于制备抗原搜索样结合蛋白的方法。
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公开(公告)号：EP3259282A1
公开(公告)日：2017-12-27
申请号：EP16704641.6
申请日：2016-02-16
申请人： SANOFI
发明人： CORVEY, Carsten , STUMP, Heike , KRUIP, Jochen , CALANDRA, Bernhard , REY, Astrid , KARST, Nathalie , MOUREZ, Michael , FRAISSE, Laurent , ROTHE, Christine , ALLERSDORFER, Andrea , WIEDENMANN, Alexander , HINNER, Marlon , LUNDE, Bradley , JENSEN, Kristian , HÜLSMEYER, Martin
CPC分类号： C07K14/4703 , A61K38/00 , A61K38/005 , A61K38/012 , C07K14/47
摘要： The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of P. aeruginosa. The present disclosure also concerns methods of making one or more pyoverdine- or pyochelin-binding muteins described herein as well as compositions comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these muteins as well as compositions comprising one or more of such muteins.
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4.发明授权DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION 有权抗体结合带双可变区相关蛋白及结合区域交叉对准
公开(公告)号：EP2691416B1
公开(公告)日：2016-05-18
申请号：EP12716818.5
申请日：2012-03-28
申请人： SANOFI
发明人： BAURIN, Nicolas , BEIL, Christian , CORVEY, Carsten , LANGE, Christian , LI, Danxi , MIKOL, Vincent , STEINMETZ, Anke , RAO, Ercole
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
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公开(公告)号：EP3443006A2
公开(公告)日：2019-02-20
申请号：EP17732263.3
申请日：2017-04-13
申请人： Sanofi
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6.发明公开DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION 有权抗体结合带双可变区相关蛋白及结合区域交叉对准
公开(公告)号：EP2691416A1
公开(公告)日：2014-02-05
申请号：EP12716818.5
申请日：2012-03-28
申请人： SANOFI
发明人： BAURIN, Nicolas , BEIL, Christian , CORVEY, Carsten , LANGE, Christian , LI, Danxi , MIKOL, Vincent , STEINMETZ, Anke , RAO, Ercole
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
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7.发明公开PEPTIDE OR PEPTIDE COMPLEX BINDING TO 2 INTEGRIN AND METHODS AND USES INVOLVING THE SAME 有权ALPHA-2结合整联ANTIKOERPER和方法，为了应用
公开(公告)号：EP2611462A2
公开(公告)日：2013-07-10
申请号：EP11757216.4
申请日：2011-08-30
申请人： SANOFI
发明人： CORVEY, Carsten , BLUM, Horst , CAMERON, Béatrice , DABDOUBI, Tarik , DECARY, Stephanie , BAURIN, Nicolas , PAPIN, David , LANGE, Christian
IPC分类号： A61K39/395 , C07K16/28 , G01N33/68 , A61P9/10 , A61P35/00 , A61P29/00 , A61P37/02 , A61P3/10 , A61P17/06
CPC分类号： C07K16/2842 , C07K16/2839 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6857 , G01N33/6872 , G01N2333/70546 , G01N2333/7055
摘要： The present invention relates to a peptide or peptide complex binding to α2 integrin, to one or more nucleic acid(s) coding for the peptide or peptide complex, a recombinant cell producing the peptide or peptide complex, a method for producing the peptide or peptide complex, a pharmaceutical composition comprising the peptide or peptide complex or the nucleic acid(s)for use as a medicament, a method for detecting α2 integrin and a screening method.
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8.发明公开NOVEL ANTAGONIST ANTIBODIES AND THEIR FAB FRAGMENTS AGAINST GPVI AND USES THEREOF 有权新型拮抗剂抗体及其Fab片段AGAINST GPVI及其用途
公开(公告)号：EP2513147A2
公开(公告)日：2012-10-24
申请号：EP10813028.7
申请日：2010-12-17
申请人： SANOFI
发明人： BAURIN, Nicolas , BLANCHE, Francis , CAMERON, Béatrice , CORVEY, Carsten , DABDOUBI, Tarik , ENGEL, Christian , FLORIAN, Peter , FOCKEN, Ingo , KROLL, Katja , KRUIP, Jochen , LANGE, Christian , LANGER, Thomas , LORENZ, Martin , MIKOL, Vincent , RAO, Ercole , WONEROW, Peter
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K1/1075 , C07K16/2803 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： FR2009/113 PCT PATENT APPLICATION TITLE Novel antagonist antibodies and their Fab fragments against GPVI and uses thereof SANOFI-AVENTIS ABSTRACT The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab. The invention concerns a method for prevention of platelet activation when an anti-GP VI Fab is used.
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公开(公告)号：EP4257193A2
公开(公告)日：2023-10-11
申请号：EP23179697.0
申请日：2017-04-13
申请人： Sanofi
发明人： YANG, Zhi-Yong , LANGE, Christian , CORVEY, Carsten , NABEL, Gary J. , WU, Lan , SEUNG, Edward , WEI, Ronnie , BENINGA, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian
IPC分类号： A61P29/00
摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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公开(公告)号：EP3319986A1
公开(公告)日：2018-05-16
申请号：EP16736427.2
申请日：2016-07-06
申请人： SANOFI
发明人： CORVEY, Carsten , STUMP, Heike , KRUIP, Jochen , LANGE, Christian , FOCKEN, Ingo , RAT, Dorothea , STUEDEMANN, Thomas , RASSER, Hans-Falk , SCHAEFER, Juergen , CALANDRA, Bernhard , REY, Astrid , MOUREZ, Michael , FRAISSE, Laurent , ROTHE, Christine , ALLERSDORFER, Andrea , WIEDENMANN, Alexander , HINNER, Marlon , LUNDE, Bradley , JENSEN, Kristian , HÜLSMEYER, Martin
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/50 , C07K2319/70
摘要： The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.
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