专利检索 ap:("TEKMIRA Pharmaceuticals Corporation" OR "THE UNIVERSITY OF BRITISH COLUMBIA" OR "Alnylam Pharmaceuticals") AND inv:"MADDEN, Thomas, D." 第 2 页

11.

发明公开
BILAYER STABILIZING COMPONENTS AND THEIR USE IN FORMING PROGRAMMABLE FUSOGENIC LIPOSOMES 失效
标题翻译：双层稳定成分及其用途在教育可编程融合脂质体

公开(公告)号：EP0792142A1

公开(公告)日：1997-09-03

申请号：EP95932595.0

申请日：1995-10-02

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： HOLLAND, John, W. , MADDEN, Thomas, D. , CULLIS, Pieter, R.

IPC分类号： A61K9 , A61K47 , B01J13

CPC分类号： A61K9/1272 , Y10T428/2984

摘要： The present invention provides a fusogenic liposome comprising a lipid capable of adopting a non-lamellar phase, yet capable of assuming a bilayer structure in the presence of a bilayer stabilizing component; and a bilayer stabilizing component reversibly associated with the lipid to stabilize the lipid in a bilayer structure. Such fusogenic liposomes are extremely advantageous because the rate at which they become fusogenic can be not only predetermined, but varied as required over a time scale ranging from minutes to days. Control of liposome fusion can be achieved by modulating the chemical stability and/or exchangeability of the bilayer stabilizing component(s). The fusogenic liposomes of the present invention can be used to deliver drugs, peptide, proteins, RNA, DNA or other bioactive molecules to the target cells of interest.

12.

发明公开
METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS 审中-公开

公开(公告)号：EP3494963A1

公开(公告)日：2019-06-12

申请号：EP18203249.0

申请日：2010-12-17

申请人： The University of British Columbia , Arbutus Biopharma Corporation

发明人： HOPE, Michael, J. , MADDEN, Thomas, D. , CULLIS, Pieter , MAIER, Martin, A. , JAYARAMAN, Muthusamy , RAJEEV, Kallanthottathil, G. , AKINC, Akin , MANOHARAN, Muthiah , HAFEZ, Ismail Mahmoud

IPC分类号： A61K9/127 , A61K9/133 , C12N15/88 , A61K47/69 , A61K47/54

摘要： A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.

13.

发明授权
METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS 有权

公开(公告)号：EP2512449B1

公开(公告)日：2019-08-07

申请号：EP10838298.7

申请日：2010-12-17

申请人： The University of British Columbia , Arbutus Biopharma Corporation

发明人： HOPE, Michael, J. , MADDEN, Thomas, D. , CULLIS, Pieter , MAIER, Martin, A. , JAYARAMAN, Muthusamy , RAJEEV, Kallanthottathil, G. , AKINC, Akin , MANOHARAN, Muthiah , HAFEZ, Ismail Mahmoud

IPC分类号： A61K9/127 , C12N15/88

14.

发明授权
FUSOGENIC LIPOSOMES 失效
标题翻译：融合脂质体

公开(公告)号：EP0792142B1

公开(公告)日：2001-12-05

申请号：EP95932595.2

申请日：1995-10-02

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： HOLLAND, John, W. , MADDEN, Thomas, D. , CULLIS, Pieter, R.

IPC分类号： A61K9/127

CPC分类号： A61K9/1272 , Y10T428/2984

15.

发明授权
LIPOSOMAL FORMULATIONS COMPRISING DIHYDROSPHINGOMYELIN AND METHODS OF USE THEREOF 有权
标题翻译：与DIHYDROSPHINGOMYELIN脂质体制剂及其使用方法

公开(公告)号：EP1750673B1

公开(公告)日：2009-12-02

申请号：EP05783321.2

申请日：2005-05-16

申请人： Tekmira Pharmaceuticals Corporation

发明人： CULLIS, Pieter, R. , MADDEN, Thomas, D. , HOPE, Michael, J. , ANSELL, Steven, M. , MUI, Barbara, L.S. , SEMPLE, Sean, C. , MAURER, Norbert

IPC分类号： A61K9/127

CPC分类号： A61K31/4745 , A61K9/1272 , A61K9/1278 , A61K33/32 , A61K2300/00