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公开(公告)号：EP2262793B1
公开(公告)日：2012-10-03
申请号：EP09752057.1
申请日：2009-11-05
发明人： STERIMBAUM, Greta , LEVI, Sigalit , YEORI, Adi , KOLTAI, Tamas , NIDDAM-HILDESHEIM, Valerie , PIRAN, Maytal , ASIS, Shay , EISEN-NEVO, Hagit , CROWE, David, Malcolm
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14
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公开(公告)号：EP2262793A2
公开(公告)日：2010-12-22
申请号：EP09752057.1
申请日：2009-11-05
发明人： STERIMBAUM, Greta , LEVI, Sigalit , YEORI, Adi , KOLTAI, Tamas , NIDDAM-HILDESHEIM, Valerie , PIRAN, Maytal , ASIS, Shay , EISEN-NEVO, Hagit , CROWE, David, Malcolm
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14
摘要： Crystalline forms of Nilotinib HCl are described. (I)
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公开(公告)号：EP2043639A2
公开(公告)日：2009-04-08
申请号：EP07810765.3
申请日：2007-07-24
发明人： KOLTAI, Tamas , NIDAM, Tamar , GILBOA, Eyal , PERLMAN, Nurit , PINHASOV, Michael , ABRAMOV, Mili
IPC分类号： A61K31/435
CPC分类号： C07D453/02
摘要： Polymorphic forms of solifenacin have been prepared and characterized. These polymorphic forms are particularly useful in pharmaceutical compositions.
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公开(公告)号：EP1893195A2
公开(公告)日：2008-03-05
申请号：EP06785363.0
申请日：2006-06-22
IPC分类号： A61K31/404 , C07D209/14
CPC分类号： C07D209/14
摘要： Provided are crystalline forms of tegaserod maleate and processes for the preparation thereof.
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公开(公告)号：EP1844034A1
公开(公告)日：2007-10-17
申请号：EP06825070.3
申请日：2006-09-21
发明人： INI, Santiago , ABRAMOV, Mili , KOLTAI, Tamas
IPC分类号： C07D333/16 , A61K31/381 , A61P25/24
CPC分类号： C07D333/16 , A61K31/38 , C07D333/20
摘要： (S)-N,N-Dimethyl-3-(l-naphthalenyloxy)-3-(2-thienyl)propanamine fumarate (DNT-fumarate) and polymorphs of DNT-fumarate, compositions of DNT-fumarate and its polymorphs, processes for the preparation of DNT-fumarate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-fumarate are provided.
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公开(公告)号：EP1838692A2
公开(公告)日：2007-10-03
申请号：EP06815168.7
申请日：2006-09-21
发明人： INI, Santiago , LIBERMAN, Anita , ABRAMOV, Mili , KOLTAI, Tamas
IPC分类号： C07D333/20
CPC分类号： C07D333/20 , A61K31/38
摘要： (S)-N,N-Dimethyl-3-(l-naphtlialenyloxy)-3-(2-thienyl)propanamine nialeate (DNT-maleate) and polymorphs of DNT-maleate, compositions of DNT-maleate and its polymorphs, processes for the preparation of DNT-maleate and its polymorphs, and processes for the preparation of duloxetine hydrochloride from DNT-maleate are provided.
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公开(公告)号：EP1745028A2
公开(公告)日：2007-01-24
申请号：EP05773390.9
申请日：2005-06-29
IPC分类号： C07D263/20 , A61K31/421
CPC分类号： C07D263/20
摘要： Novel crystalline forms of Linezolid, designated as Form TIII, Form V, Form VI, Form IX, Form X, Form XII, Form XIV, Form XVII, and Form XVIII, are disclosed. The novel crystalline forms are characterized by powder X-ray diffraction, FTIR and FTRaman spectroscopy, and differential scanning calorimetry. Methods of preparing the novel crystalline forms, pharmaceutical compositions comprising the novel crystalline forms, and methods of using the novel crystalline forms to treat gram positive bacterial infections are also described. Amorphous Linezolid is also disclosed.
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公开(公告)号：EP1592688A2
公开(公告)日：2005-11-09
申请号：EP04815237.5
申请日：2004-12-20
发明人： ARONHIME, Judith , MENDELOVICI, Marioara , KOLTAI, Tamas , MOSHKOVITS-KAPTSAN, Rinat , NIDAM, Tamar
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： Provided is a crystalline form of ziprasidone base and processes for its preparation.
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公开(公告)号：EP2101570B1
公开(公告)日：2013-02-13
申请号：EP07867741.6
申请日：2007-12-13
发明人： FRENKEL, Anton , KOLTAI, Tamas
IPC分类号： C07C211/42 , C07H13/08
CPC分类号： C07C211/42 , C07C2602/08 , C07H13/08
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公开(公告)号：EP2381767A1
公开(公告)日：2011-11-02
申请号：EP10733731.3
申请日：2010-01-21
发明人： SAFADI, Muhammad , LICHT, Daniella , COHEN, Rachel , FRENKEL, Anton , KOLTAI, Tamas , ZHOLKOVSKY, Marina
IPC分类号： A01N3/02 , A61K31/135
CPC分类号： A61K9/2893 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K9/2846 , A61K9/2886 , A61K31/135 , C07C59/265 , C07C211/42 , C07C2602/08
摘要： Disclosed are formulations of rasagiline base which are designed to delay release of rasagiline while maintaining specific pharmacokinetic properties. Also, disclosed are rasagiline citrate salt and the use and process of manufacture thereof.
摘要翻译： 公开了雷沙吉兰碱的制剂，其被设计为延迟雷沙吉兰的释放，同时保持特定的药代动力学性质。 还公开了雷沙吉兰柠檬酸盐及其用途和制造方法。
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