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公开(公告)号：EP1294347A2
公开(公告)日：2003-03-26
申请号：EP01946731.5
申请日：2001-06-28
发明人： WITT, Jonathan, James , WIMALASENA, Rohan, Lalith , WONG, Andrew, Lee , GOULBOURNE Jr., Eric, Altman , DOYLE, Matthew, Joseph
摘要： The present invention relates to topical oral compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, lozenges (including breath mints), dental implements (such as dental floss and tape), and pet care products comprising at least a minimally effective amount of chlorite ion, wherein the pH of the final composition is greater than 7 and the composition is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing diseases and conditions of the oral cavity such as gingivitis, plaque, periodontal disease, herpetic lesions, and infections that may develop following dental procedures such as osseous surgery, tooth extraction, periodontal flap surgery, dental implantation, and scaling and root planing, in humans and other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
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公开(公告)号：EP1294345A2
公开(公告)日：2003-03-26
申请号：EP01948785.9
申请日：2001-06-28
发明人： DOYLE, Matthew, Joseph , HUNTER-RINDERLE, Stephen, Joseph , SINGER, Robert, Ernest, Jr. , WIMALASENA, Rohan, Lalith
摘要： The present invention relates to promoting whole body health in humans and animals by using topical oral compositions comprising a safe and effective amount of chlorite ion in admixture with a pharmaceutically acceptable carrier, said compositions being effective in controlling bacterial-mediated diseases and conditions present in the oral cavity and inhibiting the spread into the bloodstream of oral pathogenic bacteria and associated bacterial toxins and resultant inflammatory cytokines and mediators. The present invention also encompasses methods of use of these compositions by topically applying to the oral cavity, a safe and effective amount of chlorite ion to promote and/or enhance whole body health in humans and other animals.
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公开(公告)号：EP1056438B1
公开(公告)日：2002-12-04
申请号：EP99903850.8
申请日：1999-02-26
摘要： The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chloride dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitis, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
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14.发明授权BIOMARKER-BASED METHODS FOR IDENTIFYING AND FORMULATING COMPOSITIONS THAT IMPROVE SKIN QUALITY AND REDUCE THE VISIBLE SIGNS OF AGING IN SKIN 有权ON基于生物标记鉴定方法和组合物改善皮肤质量的表达和抑制老化的迹象
公开(公告)号：EP2524225B1
公开(公告)日：2017-04-19
申请号：EP10757649.8
申请日：2010-06-25
发明人： WIMALASENA, Rohan, Lalith , STELLA,Qing , WEI, Karl, Shiqing , GARZA, Cynthia, A. , WEHMEYER, Kenneth, Robert
CPC分类号： A61K8/31 , A61K8/03 , A61K8/96 , A61K49/0006 , A61K2800/87 , A61Q19/10 , G01N33/5088 , G01N33/62 , G01N33/6812 , G01N33/6827 , G01N33/6869 , G01N33/6881 , G01N33/92 , G01N2333/4742 , G01N2333/545 , G01N2500/04 , G01N2800/20 , G06Q30/0201
摘要： In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes (e.g. lipids such as ceramides and fatty acids; natural moisturizing factors such as trans-urocanic acid, citrulline, glycine, histidine, ornithine, proline, 2-pyrrolidone-5 acid, serine) that correlate with improvement as evidenced by one or more objective measurements of skin health.
摘要翻译： 提供了一种用于递送的洗去型个人皮肤护理组合物的皮肤的治疗方案。 所述洗去型个人皮肤护理组合物包括改变的起泡剂的比率为疏水性有益剂。 所述洗去型个人皮肤护理组合物可以在相之上和/或在一个治疗周期被施加到使用者的皮肤上。 每个治疗周期的相位可包括不同比率的比率确实可以是不同的：例如大于相邻相的比例更高或更低。
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15.发明公开BIOMARKER-BASED METHODS FOR IDENTIFYING AND FORMULATING COMPOSITIONS THAT IMPROVE SKIN QUALITY AND REDUCE THE VISIBLE SIGNS OF AGING IN SKIN 有权ON基于生物标记鉴定方法和组合物改善皮肤质量的表达和抑制老化的迹象
公开(公告)号：EP2524225A1
公开(公告)日：2012-11-21
申请号：EP10757649.8
申请日：2010-06-25
发明人： WIMALASENA, Rohan, Lalith , STELLA,Qing , WEI, Karl, Shiqing , GARZA, Cynthia, A. , WEHMEYER, Kenneth, Robert
CPC分类号： A61K8/31 , A61K8/03 , A61K8/96 , A61K49/0006 , A61K2800/87 , A61Q19/10 , G01N33/5088 , G01N33/62 , G01N33/6812 , G01N33/6827 , G01N33/6869 , G01N33/6881 , G01N33/92 , G01N2333/4742 , G01N2333/545 , G01N2500/04 , G01N2800/20 , G06Q30/0201
摘要： In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes (e.g. lipids such as ceramides and fatty acids; natural moisturizing factors such as trans-urocanic acid, citrulline, glycine, histidine, ornithine, proline, 2-pyrrolidone-5 acid, serine) that correlate with improvement as evidenced by one or more objective measurements of skin health.
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16.发明公开
公开(公告)号：EP2381914A2
公开(公告)日：2011-11-02
申请号：EP10722207.7
申请日：2010-01-28
发明人： PUTMAN, Christopher, Dean , CETTI, Jonathan, Robert , WEHMEYER, Kenneth, Robert , WEI, Karl, Shiqing , WIMALASENA, Rohan, Lalith , BIEHLE, Susan, Jeane , FARRIS, Richard, Duffy
IPC分类号： A61K8/03
CPC分类号： A61K8/31 , A61K8/03 , A61K2800/87 , A61Q19/10
摘要： In various embodiments, provided are (i) methods and regimens for application of a personal care product for treating and maintaining the quality of skin, wherein a composition formulated to comprise at least two benefit agents, such as a lathering agent and a hydrophobic benefit agent, is applied to the user's skin over a treatment cycle that comprises two or more stages; (ii) methods for identifying and providing personal care products for treating and maintaining the quality of skin to specific populations of users; and (iii) methods for assessing, treating and maintaining the quality of skin and minimizing the signs of aging by assessing the activity of one or more skin biomarkers or physical properties that are indicative of skin quality.
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公开(公告)号：EP1056436B1
公开(公告)日：2004-07-21
申请号：EP99902792.3
申请日：1999-02-26
摘要： The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitis, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
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公开(公告)号：EP1056439B1
公开(公告)日：2002-10-30
申请号：EP99903851.6
申请日：1999-02-26
摘要： The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitus, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
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