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1.发明公开A NONINVASIVE METHOD FOR MEASURING HISTAMINE FROM SKIN AS AN OBJECTIVE MEASURMENT OF ITCH 有权FROM AS LENSES瘙痒测量皮肤测量组胺的非侵入性方法
公开(公告)号：EP2478376A1
公开(公告)日：2012-07-25
申请号：EP10755273.9
申请日：2010-09-09
发明人： SCHWARTZ, James, Robert , KERR, Kathleen, Marie , DOYLE, Patricia, West , WEHMEYER, Kenneth, Robert , BURT, Thomas, Massey , FIENO, Angela, Marie , WIMALASENA, Rohan, Lalith , FADAYEL, Gina, Marie
CPC分类号： G01N33/6881 , G01N2001/2833 , G01N2001/4061
摘要： A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.
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2.发明公开METHODS FOR IMPROVING SKIN QUALITY USING RINSE-OFF PERSONAL CARE COMPOSITIONS WITH VARIABLE AMOUNTS OF HYDROPHOBIC BENEFIT AGENTS 审中-公开使用具有可变量疏水性有益剂的冲洗性个人护理组合物来改善皮肤质量的方法
公开(公告)号：EP2384187A2
公开(公告)日：2011-11-09
申请号：EP10709102.7
申请日：2010-01-28
发明人： PUTMAN, Christopher, Dean , CETTI, Jonathan, Robert , WEHMEYER, Kenneth, Robert , WEI, Karl, Shiqing , WIMALASENA, Rohan, Lalith , BIEHLE, Susan, Jeane , FARRIS, Richard, Duffy , ABSHER, Sarah, Noelle
CPC分类号： A61K8/31 , A61K8/03 , A61K2800/87 , A61Q19/10
摘要： In various embodiments, provided are (i) methods and regimens for application of a personal care product for treating and maintaining the quality of skin, wherein a composition formulated to comprise at least two benefit agents, such as a lathering agent and a hydrophobic benefit agent, is applied to the user's skin over a treatment cycle that comprises two or more stages; (ii) methods for identifying and providing personal care products for treating and maintaining the quality of skin to specific populations of users; and (iii) methods for assessing, treating and maintaining the quality of skin and minimizing the signs of aging by assessing the activity of one or more skin biomarkers or physical properties that are indicative of skin quality.
摘要翻译： 在各种实施方案中，提供了（i）用于施用个人护理产品以治疗和维持皮肤质量的方法和方案，其中配制成包含至少两种有益剂的组合物，所述有益剂例如起泡剂和疏水性有益剂 通过包括两个或更多阶段的治疗周期应用于使用者的皮肤; （ii）识别和提供个人护理产品用于治疗和维持特定人群的皮肤质量的方法; 和（iii）通过评估一种或多种皮肤生物标志物或指示皮肤质量的物理特性的活性来评估，治疗和维持皮肤质量并使老化迹象最小化的方法。
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3.发明公开METHODS FOR IMPROVING SKIN QUALITY USING RINSE-OFF PERSONAL CARE COMPOSITIONS WITH VARIABLE AMOUNTS OF HYDROPHOBIC BENEFIT AGENTS 审中-公开方法改善皮肤质量使用可清洗的个人护理组合具有疏水活性成分的可变量
公开(公告)号：EP2384185A2
公开(公告)日：2011-11-09
申请号：EP10708663.9
申请日：2010-01-28
发明人： PUTMAN, Christopher, Dean , CETTI, Jonathan, Robert , WEHMEYER, Kenneth, Robert , WEI, Karl, Shiqing , WIMALASENA, Rohan, Lalith , BIEHLE, Susan, Jeane , FARRIS, Richard, Duffy
CPC分类号： A61K8/31 , A61K8/03 , A61K2800/87 , A61Q19/10
摘要： In various embodiments, provided are (i) methods and regimens for application of a personal care product for treating and maintaining the quality of skin, wherein a composition formulated to comprise at least two benefit agents, such as a lathering agent and a hydrophobic benefit agent, is applied to the user's skin over a treatment cycle that comprises two or more stages; (ii) methods for identifying and providing personal care products for treating and maintaining the quality of skin to specific populations of users; and (iii) methods for assessing, treating and maintaining the quality of skin and minimizing the signs of aging by assessing the activity of one or more skin biomarkers or physical properties that are indicative of skin quality.
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公开(公告)号：EP1056436A1
公开(公告)日：2000-12-06
申请号：EP99902792.3
申请日：1999-02-26
摘要： The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitis, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
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5.发明授权A NONINVASIVE METHOD FOR MEASURING HISTAMINE FROM SKIN AS AN OBJECTIVE MEASURMENT OF ITCH 有权FROM AS LENSES瘙痒测量皮肤测量组胺的非侵入性方法
公开(公告)号：EP2478376B1
公开(公告)日：2015-06-17
申请号：EP10755273.9
申请日：2010-09-09
发明人： SCHWARTZ, James, Robert , KERR, Kathleen, Marie , DOYLE, Patricia, West , WEHMEYER, Kenneth, Robert , BURT, Thomas, Massey , FIENO, Angela, Marie , WIMALASENA, Rohan, Lalith , FADAYEL, Gina, Marie
CPC分类号： G01N33/6881 , G01N2001/2833 , G01N2001/4061
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6.发明公开BIOMARKER-BASED METHODS FOR FORMULATING COMPOSITIONS THAT IMPROVE SKIN QUALITY AND REDUCE THE VISIBLE SIGNS OF AGING IN SKIN FOR INDIVIDUALS IN A SELECTED POPULATION 审中-公开ON基于生物标志物PROCESS FOR组合物用于改善皮肤质量和减少老化的迹象人员对特定人口表达
公开(公告)号：EP2524224A1
公开(公告)日：2012-11-21
申请号：EP10743268.4
申请日：2010-06-25
发明人： STELLA, Qing , WEI, Karl, Shiqing , GARZA, Cynthia, A. , WEHMEYER, Kenneth, Robert , WIMALASENA, Rohan, Lalith
CPC分类号： A61K8/31 , A61K8/03 , A61K8/96 , A61K49/0006 , A61K2800/87 , A61Q19/10 , G01N33/5088 , G01N33/62 , G01N33/6812 , G01N33/6827 , G01N33/6869 , G01N33/6881 , G01N33/92 , G01N2333/4742 , G01N2333/545 , G01N2500/04 , G01N2800/20 , G06Q30/0201
摘要： In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes (e.g. lipids such as ceramides and fatty acids; natural moisturizing factors such as trans-urocanic acid, citrulline, glycine, histidine, ornithine, proline, 2-pyrrolidone-5 acid, serine) that correlate with improvement as evidenced by one or more objective measurements of skin health.
摘要翻译： 提供了一种用于递送的洗去型个人皮肤护理组合物的皮肤的治疗方案。 所述洗去型个人皮肤护理组合物包括改变的起泡剂的比率为疏水性有益剂。 所述洗去型个人皮肤护理组合物可以在相之上和/或在一个治疗周期被施加到使用者的皮肤上。 每个治疗周期的相位可包括不同比率的比率确实可以是不同的：例如大于相邻相的比例更高或更低。
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公开(公告)号：EP1056439A1
公开(公告)日：2000-12-06
申请号：EP99903851.6
申请日：1999-02-26
摘要： The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chlorine dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitus, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
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公开(公告)号：EP1056438A1
公开(公告)日：2000-12-06
申请号：EP99903850.8
申请日：1999-02-26
摘要： The present invention relates to oral care compositions, including therapeutic rinses, especially mouth rinses, as well as toothpastes, gels, tooth powders, chewing gums, mouth sprays, and lozenges (including breath mints), comprising at least a minimally effective amount of chlorite ion, wherein preferably the pH of the final composition is greater than 7 and level of chloride dioxide or chlorous acid is less than about 50 ppm, preferably is essentially free of chlorine dioxide or chlorous acid. This invention further relates to a method for treating or preventing gingivitis, plaque, periodontal disease, and/or breath malodor, and/or for the whitening of teeth, in humans or other animals, by applying a safe and effective amount of the chlorite ion composition to the oral cavity.
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9.发明授权BIOMARKER-BASED METHODS FOR FORMULATING COMPOSITIONS THAT IMPROVE SKIN QUALITY AND REDUCE THE VISIBLE SIGNS OF AGING IN SKIN 有权基于生物标志物的方法用于配制改善皮肤质量并减少皮肤衰老的可见迹象的组合物
公开(公告)号：EP2524223B1
公开(公告)日：2018-03-21
申请号：EP10743267.6
申请日：2010-06-25
发明人： STELLA, Qing , WEI, Karl, Shiqing , GARZA, Cynthia, A. , WEHMEYER, Kenneth, Robert , WIMALASENA, Rohan, Lalith
CPC分类号： A61K8/31 , A61K8/03 , A61K8/96 , A61K49/0006 , A61K2800/87 , A61Q19/10 , G01N33/5088 , G01N33/62 , G01N33/6812 , G01N33/6827 , G01N33/6869 , G01N33/6881 , G01N33/92 , G01N2333/4742 , G01N2333/545 , G01N2500/04 , G01N2800/20 , G06Q30/0201
摘要： In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes (e.g. lipids such as ceramides and fatty acids; natural moisturizing factors such as trans-urocanic acid, citrulline, glycine, histidine, ornithine, proline, 2-pyrrolidone-5 acid, serine) that correlate with improvement as evidenced by one or more objective measurements of skin health.
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10.发明公开BIOMARKER-BASED METHODS FOR FORMULATING COMPOSITIONS THAT IMPROVE SKIN QUALITY AND REDUCE THE VISIBLE SIGNS OF AGING IN SKIN 有权ON基于生物标志物PROCESS FOR组合物用于改善皮肤质量和减少老化的迹象表达
公开(公告)号：EP2524223A1
公开(公告)日：2012-11-21
申请号：EP10743267.6
申请日：2010-06-25
发明人： STELLA, Qing , WEI, Karl, Shiqing , GARZA, Cynthia, A. , WEHMEYER, Kenneth, Robert , WIMALASENA, Rohan, Lalith
CPC分类号： A61K8/31 , A61K8/03 , A61K8/96 , A61K49/0006 , A61K2800/87 , A61Q19/10 , G01N33/5088 , G01N33/62 , G01N33/6812 , G01N33/6827 , G01N33/6869 , G01N33/6881 , G01N33/92 , G01N2333/4742 , G01N2333/545 , G01N2500/04 , G01N2800/20 , G06Q30/0201
摘要： In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes (e.g. lipids such as ceramides and fatty acids; natural moisturizing factors such as trans-urocanic acid, citrulline, glycine, histidine, ornithine, proline, 2-pyrrolidone-5 acid, serine) that correlate with improvement as evidenced by one or more objective measurements of skin health.
摘要翻译： 提供了一种用于递送的洗去型个人皮肤护理组合物的皮肤的治疗方案。 所述洗去型个人皮肤护理组合物包括改变的起泡剂的比率为疏水性有益剂。 所述洗去型个人皮肤护理组合物可以在相之上和/或在一个治疗周期被施加到使用者的皮肤上。 每个治疗周期的相位可包括不同比率的比率确实可以是不同的：例如大于相邻相的比例更高或更低。
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