公开(公告)号：EP0031567A3

公开(公告)日：1981-11-04

申请号：EP80108083

申请日：1980-12-20

申请人： Takeda Chemical Industries, Ltd.

发明人： Masahiko, Fujino ,  Mitsuhiro, Wakumasu ,  Kiyohisa, Kawai

IPC分类号： C07C103/52 ,  A61K37/02 ,  C07C133/00 ,  C07C159/00

CPC分类号： C07K5/0812 ,  C07K5/1016 ,  Y02P20/55

摘要： Novel tetrapeptidesemicarbazide derivatives, inclusive of a pharmacologically acceptable salt thereof, which has the general formula (I):
wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or a D-α-amino acid side chain; R 3 is hydrogen or lower alkyl; X is oxygen or sulfur, are useful as analgesics.