公开(公告)号：EP1333753A2

公开(公告)日：2003-08-13

申请号：EP01994409.9

申请日：2001-10-19

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： ECHAUZ, Javier, Ramon ,  ESTELLER, Rosana ,  LITT, Brian ,  VACHTSEVANOS, George, John

IPC分类号： A61B5/04

CPC分类号： A61B5/7267 ,  A61B5/0476 ,  A61B5/076 ,  A61B5/4094 ,  A61B5/7275 ,  A61N1/08 ,  A61N1/36017 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G06K9/6262 ,  G06K9/627 ,  G06K9/6278 ,  G16H50/20 ,  G16H50/50

摘要： The invention relates to a system for automatically predicting and preventing the electrographic onset of a seizure in an individual, comprising: a signal acquisition component to condition and digitize a plurality of raw signals received from a transducer implanted in the individual; a preprocessor to attenuate any artifacts in the plurality of digitized signals; a feature extraction component containing processing logic to select patient-specific seizure-predictive and seizure-indicative attributes from the preprocessed signals to form an optimal feature vector; a probability estimator component that synthesizes a probability vector as an estimator of the likelihood of seizure for a plurality of prediction times; a ultitherapy activation component containing processing logic to determine the therapy modalities that are to be activated or deactivated at any time; and an implanted device including a plurality of therapy actuators to automatically activate at least one associated therapy in response to an output signal from the multitherapy activation component.