公开(公告)号：EP1341580A2

公开(公告)日：2003-09-10

申请号：EP01993260.7

申请日：2001-12-11

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： ESTELLER, Rosana ,  ECHAUZ, Javier, Ramon ,  LITT, Brian ,  VACHTSEVANOS, George, John

IPC分类号： A61N1/18

CPC分类号： A61B5/076 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/4094 ,  A61B5/486 ,  A61B5/7203 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/7275 ,  A61N1/08 ,  A61N1/36082 ,  G06F19/00 ,  G06K9/00523

摘要： A method and apparatus for forecasting and controlling neurological abnormalities in humans such as seizures or other brain disturbances. The system is based on a multi-level control strategy. Using as inputs one or more types of physiological measures such as brain electrical, chemical or magnetic activity, heart rate, pupil dilation, eye movement, temperature, chemical concentration of certain substances, a feature set is selected off-line from a pre-programmed feature library contained in a high level controller within a supervisory control architecture. This high level controller stores the feature library within a notebook or external PC. The supervisory control also contains a knowledge base that is continuously updated at discrete steps with the feedback information coming from an implantable device where the selected feature set (feature vector) is implemented. This high level controller also establishes the initial system settings (off-line) and subsequent settings (on-line) or tunings through an outer control loop by an intelligent procedure that incorporates knowledge as it arises. The subsequent adaptive settings for the system are determined in conjunction with a low-level controller that resides within the implantable device. The device has the capabilities of forecasting brain disturbances, controlling the disturbances, or both. Forecasting is achieved by indicating the probability of an oncoming seizure within one or more time frames, which is accomplished through an inner-loop control law and a feedback necessary to prevent or control the neurological event by either electrical, chemical, cognitive, sensory, and/or magnetic stimulation.

公开(公告)号：EP1333753A2

公开(公告)日：2003-08-13

申请号：EP01994409.9

申请日：2001-10-19

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： ECHAUZ, Javier, Ramon ,  ESTELLER, Rosana ,  LITT, Brian ,  VACHTSEVANOS, George, John

IPC分类号： A61B5/04

CPC分类号： A61B5/7267 ,  A61B5/0476 ,  A61B5/076 ,  A61B5/4094 ,  A61B5/7275 ,  A61N1/08 ,  A61N1/36017 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  G06F19/00 ,  G06F19/3456 ,  G06F19/3481 ,  G06K9/6262 ,  G06K9/627 ,  G06K9/6278 ,  G16H50/20 ,  G16H50/50

摘要： The invention relates to a system for automatically predicting and preventing the electrographic onset of a seizure in an individual, comprising: a signal acquisition component to condition and digitize a plurality of raw signals received from a transducer implanted in the individual; a preprocessor to attenuate any artifacts in the plurality of digitized signals; a feature extraction component containing processing logic to select patient-specific seizure-predictive and seizure-indicative attributes from the preprocessed signals to form an optimal feature vector; a probability estimator component that synthesizes a probability vector as an estimator of the likelihood of seizure for a plurality of prediction times; a ultitherapy activation component containing processing logic to determine the therapy modalities that are to be activated or deactivated at any time; and an implanted device including a plurality of therapy actuators to automatically activate at least one associated therapy in response to an output signal from the multitherapy activation component.