公开(公告)号：EP2049646A2

公开(公告)日：2009-04-22

申请号：EP07872155.2

申请日：2007-07-13

申请人： Xcellerex, Inc.

发明人： GALLIHER, Parrish, M. ,  HODGE, Geoffrey, L. ,  FISHER, Michael

IPC分类号： C12M1/00 ,  B01L1/04 ,  F24F3/16

CPC分类号： C12M41/14 ,  B08B15/02 ,  C12M23/52 ,  C12M37/02 ,  C12M41/00 ,  C12M41/40 ,  Y10S55/18

摘要： Environmental containment systems, and in certain embodiments, systems and methods involving vessels and unit operations or components of cell culture, cell containment, bioreactor, chemical manufacturing, or pharmaceutical manufacturing systems provided with environmental containment are provided. Certain vessels, unit operations, devices, and components may be used to perform all or part of biological, chemical, and/or pharmaceutical manufacturing processes therein. In some embodiments, an environmental containment system includes a multi-level containment apparatus. For instance, a first substantially closed environmental containment enclosure may be contained within a second substantially closed environmental containment enclosure; the first and second enclosures may be contained in a third substantially closed environmental containment enclosure, etc. Each of the environments within the substantially closed environmental containment enclosures may be controlled independently, and leakage of any materials from an inner system may be contained by an outer system.

摘要翻译： 环境容纳系统，并且在某些实施方案中，提供涉及容器和单元操作的系统和方法或细胞培养，细胞容纳，生物反应器，化学制造或配备有环境容纳的药物制造系统的组件。 某些容器，单元操作，装置和部件可用于执行其中的全部或部分生物，化学和/或药物制造过程。 在一些实施例中，环境容纳系统包括多级容纳装置。 例如，第一基本封闭的环境安全壳可容纳在第二基本封闭的环境安全壳内; 第一和第二外壳可以容纳在第三基本上封闭的环境容纳外壳中等。基本上封闭的环境容纳外壳内的每个环境可以被独立地控制，并且内部系统的任何材料的泄漏可以被外部 系统。

公开(公告)号：EP2044190A2

公开(公告)日：2009-04-08

申请号：EP07872150.3

申请日：2007-06-15

申请人： Xcellerex, Inc.

发明人： GALLIHER, Parrish, M. ,  HODGE, Geoffrey, L. ,  FISHER, Michael

IPC分类号： C12M1/06

CPC分类号： B65D33/02 ,  B01F3/04106 ,  B01F13/0827 ,  B01F15/00831 ,  B01F15/0085 ,  B01F2215/0073 ,  B29C45/16 ,  B29K2023/0633 ,  B29L2031/7128 ,  C12M23/14 ,  C12M29/06 ,  C12M41/02

摘要： Systems for containing and manipulating fluids including systems and methods involving supported collapsible bags that may be used as reactors for performing chemical, biochemical and/or biological reactions contained therein are provided. Generally, a series of improvements and features for fluid containment systems such as gas delivery configurations, foam control systems and bag molding methods and articles for supported collapsible bag vessels and bioreactors are provided. For instance, in one aspect, fluids contained in a vessel can be sparged, e.g., such that a fluid is directed into a container of the vessel, and in some cases, the sparging can be controlled by rapidly activating or altering the degree of sparging as needed. Multiple spargers may be used in some cases. In another aspect, the vessel includes a seamless collapsible bag. In some cases, the collapsible bag may be injected, blown, or spin cast molded. In yet another aspect, the vessel includes a device which can reduce the foam produced or contained within the vessel. Sensors and/or controllers may optionally be used to monitor and/or control foaming.

摘要翻译： 用于容纳和操纵流体，包括系统和涉及支持可折叠袋方法的系统也可被用作反应器，用于执行其中所含提供化学，生物化学和/或生物反应。 通常，一系列的改进和功能流体容纳系统：提供了如气体输送构型中，泡沫控制系统和袋成型方法和用于支持可折叠袋容器和生物反应器的文章。 举例来说，在一个方面中，包含在容器中的流体可以喷射，例如，求没有流体被引导到所述容器的一个容器中，并且在一些情况下，喷射可以通过快速激活或改变喷射的程度来控制 根据需要。 多个排气管可以在某些情况下使用。 在另一个方面，该容器包括一个无缝可折叠袋。 在一些情况下，可折叠袋可以被注射，吹塑，或纺粘型浇铸模制。 在另一个方面，该容器包括一装置，其能够降低制造或在容器内包含的泡沫。 传感器和/或控制器可任选地用于监测和/或控制起泡。