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    DISPOSABLE BIOREACTOR SYSTEMS AND METHODS
    2.
    发明公开
    DISPOSABLE BIOREACTOR SYSTEMS AND METHODS 有权
    一次性生物反应器系统和程序

    公开(公告)号：EP1773976A2

    公开(公告)日：2007-04-18

    申请号：EP05763165.7

    申请日：2005-06-06

    申请人： Xcellerex, Inc.

    发明人： HODGE, Geoffrey ,  GALLIHER, Parrish ,  FISHER, Michael

    IPC分类号： C12M1/00

    CPC分类号： C12M23/14 ,  B01F13/0827 ,  B01F15/0085 ,  B01F15/00896 ,  B01F2215/0073 ,  C12M27/02 ,  C12M27/20 ,  C12M41/12 ,  C12M41/26 ,  C12M41/34 ,  C12M41/48

    摘要： Accordingly, in one embodiment of the invention, a bioreactor system is presented and includes a disposable container for housing biomaterials for processing, the disposable container including at least one input port, at least one exhaust port, at least one harvest port, and the integrity of the sterile environment is protected with sterile filters attached to all external open ports a structure for supporting the disposable container, one or more sensors for sensing one or more parameters of the biomaterials in the container, a heater for heating the contents of the container, the heater having a thermostat and mixing system arranged with the system such that biomaterials contained in the disposable container are mixed.

    LINEARLY SCALABLE SINGLE USE BIOREACTOR SYSTEM
    3.
    发明公开
    LINEARLY SCALABLE SINGLE USE BIOREACTOR SYSTEM 审中-公开
    线性扩展生物反应器系统一次性使用

    公开(公告)号：EP2663629A2

    公开(公告)日：2013-11-20

    申请号：EP12733903.4

    申请日：2012-01-11

    申请人： Xcellerex, Inc.

    发明人： TUOHEY, Colin ,  DELOGGIO, Ted ,  ERDENBERGER, Thomas ,  CLAPP, Kenneth, P. ,  DAMREN, Richard ,  GALLIHER, Parrish, M. ,  GUERTIN, Patrick ,  LEE, Jiyoung ,  FISHER, Michael

    IPC分类号： C12M1/00

    CPC分类号： C12M23/28 ,  C12M23/02 ,  C12M23/14 ,  C12M23/26 ,  C12M27/02

    摘要： Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear/scalability/performance basis and also from a validation and regulatory basis. In summary, the 10 L bioreactor system disclosed provides for "linear scalability" by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag/components, process control system, and shear rates as larger 50-5000 L systems.

    WEIGHT MEASUREMENTS OF LIQUIDS IN FLEXIBLE CONTAINERS
    5.
    发明公开
    WEIGHT MEASUREMENTS OF LIQUIDS IN FLEXIBLE CONTAINERS 审中-公开
    在柔性容器液体的重量测量

    公开(公告)号：EP2132534A1

    公开(公告)日：2009-12-16

    申请号：EP08726216.8

    申请日：2008-02-28

    申请人： Xcellerex, Inc.

    发明人： MITCHELL, Peter, A. ,  FISHER, Michael

    IPC分类号： G01F23/14 ,  C12M1/00

    CPC分类号： G01F23/14 ,  G01F23/18 ,  G01F23/20 ,  G01G17/04

    摘要： Articles and methods for measuring weight of a liquid in a disposable bag bioreactor are presented. In certain embodiments, bioreactor systems described herein include a supported container (e.g., a flexible bag in a reusable housing) for containing a liquid, and at least two pressure indicating sensors operatively associated with the container. A first pressure indicating sensor can be placed near the bottom of the container to measure the total downward force within the container, including the liquid head in the container and the gas pressure above the liquid. The second pressure indicating sensor can be placed near the top of the container to measure only the pressure at the top of or above the liquid. Signals from the pressure indicating sensors can be directed to a control system that receives the signals and calculates a difference between the signals. This difference can be used to determine a volume or a weight of the liquid in the container. Advantageously, real-time weight measurements can be obtained while the system is in operation and continuous flow processes can be monitored. Moreover, in some embodiments, the pressure indicating sensors are isolated from contact with any fluid (e.g., liquid) in the container and, therefore, do not require cleaning after processing of each batch of reactants. Contamination of the process fluid by contact with the pressure indicating sensors can also be avoided.

    CONTINUOUS RECOVERY HARVEST BAG
    9.
    发明公开
    CONTINUOUS RECOVERY HARVEST BAG 审中-公开
    具有连续恢复收集袋

    公开(公告)号：EP2470638A1

    公开(公告)日：2012-07-04

    申请号：EP10812625.1

    申请日：2010-08-26

    申请人： Xcellerex, Inc.

    发明人： TOUHEY, Colin ,  ERDENBERGER, Thomas ,  DAMREN, Richard ,  FISHER, Michael ,  SWIBES, John

    IPC分类号： C12N1/02

    CPC分类号： C12M23/26 ,  C12M23/14 ,  C12M23/28 ,  C12M23/34 ,  C12M25/16 ,  C12M29/04 ,  C12M47/02 ,  C12M47/10

    摘要： A nonporous vessel capable of holding a fluid comprises an outer wall surface and an inner wall surface, the inner wall surface defining an interior chamber for holding the fluid; a filter having a perimeter, a first surface and a second surface, and fixedly attached around its entire perimeter to a portion of the inner wall surface of the nonporous vessel, thereby forming an integrated interior bag within the nonporous vessel; and a fitment attached to the outer wall of the nonporous vessel at a portion of the outer wall that is adjacent to the first surface of the integrated interior bag, the fitment forming a port configured to allow fluid to flow from the interior chamber through the integrated interior bag, through the filter, and out of the port.