公开(公告)号：EP0839125A1

公开(公告)日：1998-05-06

申请号：EP96905351.0

申请日：1996-01-29

申请人： IMARX PHARMACEUTICAL CORP.

发明人： UNGER, Evan, C. ,  SHEN, Dekang ,  WU, Guanli

IPC分类号： C12N15 ,  A61K9 ,  A61K38 ,  A61K47 ,  A61K48 ,  A61P37 ,  C07C237 ,  C07F9 ,  C07K14

CPC分类号： C07K14/005 ,  A61K9/1272 ,  A61K38/00 ,  A61K48/00 ,  C07C237/10 ,  C07C2601/14 ,  C07F9/10 ,  C07K14/501 ,  C12N15/88 ,  C12N2760/18522 ,  Y10S436/829 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/907

摘要： Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.

公开(公告)号：EP0765865A4

公开(公告)日：1997-08-13

申请号：EP95921129

申请日：1995-06-07

申请人： SEIKAGAKU KOGYO CO LTD

发明人： INOKUCHI JINICHI ,  JINBO MASAYUKI ,  NAGAI TAKAYUKI ,  YAMADA HARUKI

IPC分类号： C07C233/36 ,  C07D207/12 ,  C07D211/22 ,  C07D211/46 ,  C07D295/125 ,  C07D295/185 ,  C07C233/43 ,  A61K31/135 ,  A61K31/44 ,  A61K31/445 ,  A61K31/54 ,  C07C235/10 ,  C07D211/40 ,  C07D211/42 ,  C07D213/40 ,  C07D295/12

CPC分类号： C07D295/185 ,  C07C233/36 ,  C07C2601/14 ,  C07D207/12 ,  C07D211/22 ,  C07D211/46 ,  C07D295/125 ,  Y10S977/798 ,  Y10S977/904 ,  Y10S977/915

摘要： A 2-acylaminopropanol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a medicinal composition containing the same as the active ingredient and being efficacious as an antiviral agent and a remedy for nervous diseases, wherein R1 represents phenyl which may be substituted by one to three same or different substituents selected from among alkyl, alkoxy, hydroxy, hydroxyalkyl and nitro; R2 represents a group represented by any of general formulae (II) through (VI) wherein, R?3, R4, R5, R6, R7, R8, R9¿, m and p are each as defined in the specification; R11 represents hydrogen or hydroxy; and n represents an integer of 3 to 15.

摘要翻译： 由通式（I）表示的2-酰氨基丙醇化合物或其药学上可接受的盐，以及含有该化合物作为活性成分并作为抗病毒剂和神经疾病治疗剂有效的药物组合物，其中R1代表可以是 被1-3个选自烷基，烷氧基，羟基，羟烷基和硝基的相同或不同的取代基取代; R2代表由通式（II）至（VI）中任何一个代表的基团，其中R 3，R 4，R 5，R 6，R 7，R 8，R 9，m和p各自如说明书中所定义; R11代表氢或羟基; 并且n表示3至15的整数。