公开(公告)号：EP1133286A1

公开(公告)日：2001-09-19

申请号：EP99959320.5

申请日：1999-11-24

申请人： Gasco, Maria Rosa

发明人： Gasco, Maria Rosa

IPC分类号： A61K9/51

CPC分类号： A61K9/5123 ,  A61K31/22 ,  A61K31/355 ,  A61K31/575 ,  Y10S977/775 ,  Y10S977/783 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/801 ,  Y10S977/912 ,  Y10S977/915

摘要： The present invention relates to pharmaceutical compositions in form of solid lipidic nanospheres able to fast penetrate into the cells, comprising as an active substance a lipidic substance consisting of an ester of α-tocopherol or δ-tocopherol or of cholesterol or of glycerol with a carboxylic acid selected from acetic acid, propionic acid, butyric acid and succinic acid, useful in the treatment of tumoral pathologies and of Mediterranean anaemia.

公开(公告)号：EP0948322A2

公开(公告)日：1999-10-13

申请号：EP97953010.0

申请日：1997-12-09

申请人： Biovector Therapeutics S.A.

发明人： BETBEDER, Didier ,  ETIENNE, Alain ,  DE MIGUEL, Ignacio ,  KRAVTZOFF, Roger ,  MAJOR, Michel

IPC分类号： A61K9

CPC分类号： A61K9/5161 ,  A61K9/167 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S977/783 ,  Y10S977/788 ,  Y10S977/795 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/83 ,  Y10S977/917

摘要： A novel method for the mucosal administration of a substance to a mammal is provided. The method comprises contacting a mucosal surface of the mammal with the substance in combination with a Biovector. The Biovector has a core that comprises a natural polymer, or a derivative or a hydrolysate of a natural polymer, or a mixture thereof. A preferred natural polymer is a polysaccharide or an oligosaccharide. The core is optionally coated with an amphiphilic compound, such as a lipid.

公开(公告)号：EP2018156B1

公开(公告)日：2010-03-17

申请号：EP07873883.8

申请日：2007-04-09

申请人： Chimeros, Inc.

发明人： DAVIS, Claude, Geoffrey ,  DE LOS RIOS, Miguel, A. ,  OH, Kenneth, J. ,  BULLOCK, Timothy, L. ,  JOHNSON, Patrick, T. ,  OSTROWSKI, Jacek

IPC分类号： A61K9/127 ,  A61K9/50

CPC分类号： A61K9/1272 ,  A61K9/5184 ,  A61K47/6849 ,  A61K47/6913 ,  A61K51/1234 ,  A61K2039/505 ,  A61K2039/5258 ,  C07K16/2803 ,  C07K16/3061 ,  C07K2317/77 ,  Y10S977/795 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/802

摘要： The present invention provides a targeted multi-layered drug delivery system for the delivery of cytotoxic agents to B-cells.

公开(公告)号：EP2018156A1

公开(公告)日：2009-01-28

申请号：EP07873883.8

申请日：2007-04-09

申请人： Chimeros, Inc.

发明人： DAVIS, Claude, Geoffrey ,  DE LOS RIOS, Miguel, A. ,  OH, Kenneth, J. ,  BULLOCK, Timothy, L. ,  JOHNSON, Patrick, T. ,  OSTROWSKI, Jacek

IPC分类号： A61K9/127 ,  A61K9/50

CPC分类号： A61K9/1272 ,  A61K9/5184 ,  A61K47/6849 ,  A61K47/6913 ,  A61K51/1234 ,  A61K2039/505 ,  A61K2039/5258 ,  C07K16/2803 ,  C07K16/3061 ,  C07K2317/77 ,  Y10S977/795 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/802

摘要： The present invention provides a targeted multi-layered drug delivery system for the delivery of cytotoxic agents to B-cells.

公开(公告)号：EP1133286B1

公开(公告)日：2004-11-24

申请号：EP99959320.5

申请日：1999-11-24

申请人： Gasco, Maria Rosa

发明人： Gasco, Maria Rosa

IPC分类号： A61K9/51

CPC分类号： A61K9/5123 ,  A61K31/22 ,  A61K31/355 ,  A61K31/575 ,  Y10S977/775 ,  Y10S977/783 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/801 ,  Y10S977/912 ,  Y10S977/915

摘要： The present invention relates to pharmaceutical compositions in form of solid lipidic nanospheres able to fast penetrate into the cells, comprising as an active substance a lipidic substance consisting of an ester of α-tocopherol or δ-tocopherol or of cholesterol or of glycerol with a carboxylic acid selected from acetic acid, propionic acid, butyric acid and succinic acid, useful in the treatment of tumoral pathologies and of Mediterranean anaemia.

公开(公告)号：EP1773303A2

公开(公告)日：2007-04-18

申请号：EP05818210.6

申请日：2005-05-25

申请人： Chimeracore, Inc.

发明人： DE LOS RIOS, Miguel, A. ,  OH, Kenneth, J.

IPC分类号： A61K9/50 ,  A61K9/127 ,  C07K14/02

CPC分类号： A61K9/5184 ,  A61K9/1277 ,  A61K9/5192 ,  A61K47/6901 ,  A61K47/6913 ,  B82Y5/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2730/10122 ,  C12N2730/10123 ,  Y10S977/795 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/802

摘要： A self-assembling nanoparticle drug delivery system for the delivery of drugs including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The self-assembling nanoparticle drug delivery system described herein includes viral capsid proteins, such as Hepatitis B Virus core protein, encapsulating the drug, a lipid bi-layer envelope and targeting or facilitating molecules anchored in the lipid bilayer. A method for construction of the self-assembling nanocparticle drug delivery system is also provided.

摘要翻译： 提供了用于递送包括肽，蛋白质，核酸或合成化学药物的药物的自组装纳米颗粒药物递送系统。 本文所述的自组装纳米颗粒药物递送系统包括病毒衣壳蛋白，例如包封药物的乙型肝炎病毒核心蛋白，脂质双层包膜和靶向或促进锚定在脂质双层中的分子。 还提供了一种用于构建自组装纳米颗粒药物递送系统的方法。

公开(公告)号：EP0839125A4

公开(公告)日：2002-10-30

申请号：EP96905351

申请日：1996-01-29

申请人： IMARX PHARMACEUTICAL CORP

发明人： UNGER EVAN C ,  SHEN DEKANG ,  WU GUANLI

IPC分类号： C12N15/09 ,  A61K9/107 ,  A61K9/127 ,  A61K38/00 ,  A61K47/14 ,  A61K47/16 ,  A61K48/00 ,  A61P37/04 ,  C07C237/10 ,  C07F9/10 ,  C07K14/135 ,  C07K14/50 ,  C12N15/88 ,  C07C69/00 ,  A61K9/50 ,  C07C233/00 ,  C12N15/64

CPC分类号： C07K14/005 ,  A61K9/1272 ,  A61K38/00 ,  A61K48/00 ,  C07C237/10 ,  C07C2601/14 ,  C07F9/10 ,  C07K14/501 ,  C12N15/88 ,  C12N2760/18522 ,  Y10S436/829 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/907

公开(公告)号：EP0765865A1

公开(公告)日：1997-04-02

申请号：EP95921129.3

申请日：1995-06-07

申请人： SEIKAGAKU CORPORATION

发明人： INOKUCHI, Jinichi ,  JINBO, Masayuki ,  NAGAI, Takayuki ,  YAMADA, Haruki

IPC分类号： C07C233/43 ,  C07C235/10 ,  C07D211/40 ,  C07D211/42 ,  C07D213/40 ,  C07D295/12 ,  A61K31/135 ,  A61K31/44 ,  A61K31/445 ,  A61K31/54

CPC分类号： C07D295/185 ,  C07C233/36 ,  C07C2601/14 ,  C07D207/12 ,  C07D211/22 ,  C07D211/46 ,  C07D295/125 ,  Y10S977/798 ,  Y10S977/904 ,  Y10S977/915

摘要： This invention relates to a 2-acylaminopropanol compound represented by the formula (I):
(wherein R 1 represents a phenyl group which may be substituted by 1 to 3 same or different substituents selected from alkyl, alkoxy, hydroxyl, hydroxyalkyl and nitro, R 2 represents the following formula (II), (III), (IV), (V) or (VI),
(wherein R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , m and p are those defined in the specification)
R 11 represents a hydrogen atom or a hydroxyl group, and n represents an integer of 3 to 15)
or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及由式（I）表示的2-酰氨基丙醇化合物：（其中R 1表示可以被1至3个相同或不同的选自烷基，烷氧基，羟基，羟烷基和硝基的取代基取代的苯基，R 2表示 （其中R 3，R 4，R 5，R 6，R 7，R 8，R 9，m和p是在说明书中定义的那些）R 11 表示氢原子或羟基，并且n表示3至15的整数）或其药学上可接受的盐。

公开(公告)号：EP0948322B1

公开(公告)日：2003-11-26

申请号：EP97953010.2

申请日：1997-12-09

申请人： CEVA SANTE ANIMALE

发明人： BETBEDER, Didier ,  ETIENNE, Alain ,  DE MIGUEL, Ignacio ,  KRAVTZOFF, Roger ,  MAJOR, Michel

IPC分类号： A61K9/51 ,  A61K9/16

CPC分类号： A61K9/5161 ,  A61K9/167 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/481 ,  Y10S977/783 ,  Y10S977/788 ,  Y10S977/795 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/83 ,  Y10S977/917

摘要： A novel method for the mucosal administration of a substance to a mammal is provided. The method comprises contacting a mucosal surface of the mammal with the substance in combination with a Biovector. The Biovector has a core that comprises a natural polymer, or a derivative or a hydrolysate of a natural polymer, or a mixture thereof. A preferred natural polymer is a polysaccharide or an oligosaccharide. The core is optionally coated with an amphiphilic compound, such as a lipid.

公开(公告)号：EP0765865B1

公开(公告)日：2001-12-12

申请号：EP95921129.3

申请日：1995-06-07

申请人： Seikagaku Corporation

发明人： INOKUCHI, Jinichi ,  JINBO, Masayuki ,  NAGAI, Takayuki ,  YAMADA, Haruki

IPC分类号： C07C233/43 ,  C07C235/10 ,  C07D211/40 ,  C07D211/42 ,  C07D213/40 ,  C07D295/12 ,  A61K31/135 ,  A61K31/44 ,  A61K31/445 ,  A61K31/54

CPC分类号： C07D295/185 ,  C07C233/36 ,  C07C2601/14 ,  C07D207/12 ,  C07D211/22 ,  C07D211/46 ,  C07D295/125 ,  Y10S977/798 ,  Y10S977/904 ,  Y10S977/915

摘要： A 2-acylaminopropanol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a medicinal composition containing the same as the active ingredient and being efficacious as an antiviral agent and a remedy for nervous diseases, wherein R1 represents phenyl which may be substituted by one to three same or different substituents selected from among alkyl, alkoxy, hydroxy, hydroxyalkyl and nitro; R2 represents a group represented by any of general formulae (II) through (VI) wherein, R?3, R4, R5, R6, R7, R8, R9¿, m and p are each as defined in the specification; R11 represents hydrogen or hydroxy; and n represents an integer of 3 to 15.

摘要翻译： 本发明涉及由式（I）表示的2-酰基氨基丙醇化合物：其中R 1表示可以被1-3个相同或不同的选自烷基，烷氧基，羟基， 羟基烷基和硝基，R 2表示下式（II），（III），（IV），（V）或（VI），（其中R 3，R 4，R 5 R 6，R 7，R 8，R 9，m和p是说明书中定义的那些，R 11表示氢原子或羟基，n表示整数 3〜15>或其药学上可接受的盐。