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39 条记录 (耗时 0.012 秒)

    Anti-diabetic agents and veterinary anti-diabetic agents
    13.
    发明公开
    Anti-diabetic agents and veterinary anti-diabetic agents 失效
    Antidiabetikafürhumane undtierärztlicheAnwendung。

    公开(公告)号：EP0462022A2

    公开(公告)日：1991-12-18

    申请号：EP91401623.3

    申请日：1991-06-17

    申请人： CHIBA FLOUR MILLING CO. LTD. ,  Soma, Gen-Ichiro ,  Mizuno, Den'Ichi

    发明人： SOMA, GEN'ICHIRO ,  YOSHIMURA, KIYOSHI ,  TSUKIOKA, DAISUKE ,  MIZUNO, DEN'ICHI, ,  OSHIMA, HARUYUKI

    IPC分类号： A61K37/20 ,  A61K35/78 ,  A61K35/74

    CPC分类号： A61K36/06 ,  A61K36/02 ,  A61K36/07 ,  A61K36/899 ,  Y02A50/473 ,  A61K2300/00

    摘要： An anti-diabetic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED₅₀ is 0.4 - 100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation abillty (%) along the axis of ordinate wherein the ability is estimated to be 0 % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100 % is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, diabetes mellitus of said animal is prevented or cured; and
       a method of treating diabetes mellitus of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the diabetes mellitus of said animal.

    摘要翻译： 一种抗糖尿病组合物，其包含有效量的至少一种LPS成分，其巨噬细胞活化ED 50为0.4-100ng / ml培养液，其鲎试验阳性LPS含量在通过测定能力制备的乙状曲线上观察到 的LPS以激活体外培养的巨噬细胞的TNF生产力，并绘制沿纵坐标轴的巨噬细胞活化能力（％），其中在对应于由TNFα产生的TNF的量的情况下，该能力估计为0％ 没有添加LPS的巨噬细胞，100％被赋予巨噬细胞活化能力，其提供由巨噬细胞产生的TNF的最大和恒定量，并沿着横坐标绘制LPS的鲎试验阳性LPS含量为对数 与药物或兽医学上可接受的载体混合，使得当施用于动物时，预防所述动物的糖尿病或c ured; 以及治疗动物糖尿病的方法，包括向所述动物施用一定量的有效预防或治愈所述动物糖尿病的上述组合物。

    Anti-herpes agents and veterinary anti-herpes agent
    14.
    发明公开
    Anti-herpes agents and veterinary anti-herpes agent 失效
    反人类和人性化的Anwendung。

    公开(公告)号：EP0462020A2

    公开(公告)日：1991-12-18

    申请号：EP91401621.7

    申请日：1991-06-17

    申请人： CHIBA FLOUR MILLING CO. LTD. ,  Soma, Gen-Ichiro ,  Mizuno, Den'Ichi

    发明人： Soma,Gen'Ichiro ,  Yoshimura, Kiyoshi ,  Tsukioka, Daisuke ,  Mizuno Den'Ichi ,  Oshima ,Haruyuki

    IPC分类号： A61K37/20 ,  A61K35/78 ,  A61K35/74

    CPC分类号： A61K36/02 ,  A61K36/06 ,  A61K36/07 ,  A61K36/899 ,  Y02A50/473 ,  A61K2300/00

    摘要： An anti-herpes composition comprising an effective amount of at l east one member of LPS whose macrophage activation ED₅₀ is 0.4 - 100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro , and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0 % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100 % is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, herpes of said animal is cured; and
       a method of treating herpes of an animal comprising administration to said animal an amount of the above composition effective to cure the herpes of said animal.

    摘要翻译： 一种抗疱疹组合物，其包含有效量的至少一种LPS的成员，其巨噬细胞活化ED 50为0.4-100ng / ml培养液，其鲎试验阳性LPS含量在通过测定能力制备的乙状曲线上观察到 的LPS以激活体外培养的巨噬细胞的TNF生产力，并绘制沿纵坐标轴的巨噬细胞活化能力（％），其中在对应于由TNFα产生的TNF的量的情况下，该能力估计为0％ 没有添加LPS的巨噬细胞，100％被赋予巨噬细胞活化能力，其提供由巨噬细胞产生的TNF的最大和恒定量，并且沿着横坐标绘制LPS的鲎试验阳性LPS含量为对数 与药学或兽医学上可接受的载体混合，使得当施用于动物时，所述动物的疱疹被固化; 以及治疗动物疱疹的方法，包括向所述动物施用一定量的上述有效治愈所述动物疱疹的组合物。

    Anti-diabetic agents and veterinary anti-diabetic agents
    20.
    发明公开
    Anti-diabetic agents and veterinary anti-diabetic agents 失效
    抗糖尿病药物和兽用抗糖尿病药

    公开(公告)号：EP0462022A3

    公开(公告)日：1992-04-29

    申请号：EP91401623.3

    申请日：1991-06-17

    申请人： CHIBA FLOUR MILLING CO. LTD. ,  Soma, Gen-Ichiro ,  Mizuno, Den'Ichi

    发明人： SOMA, GEN'ICHIRO ,  YOSHIMURA, KIYOSHI ,  TSUKIOKA, DAISUKE ,  MIZUNO, DEN'ICHI, ,  OSHIMA, HARUYUKI

    IPC分类号： A61K37/20 ,  A61K35/78 ,  A61K35/74

    CPC分类号： A61K36/06 ,  A61K36/02 ,  A61K36/07 ,  A61K36/899 ,  Y02A50/473 ,  A61K2300/00

    摘要： An anti-diabetic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED₅₀ is 0.4 - 100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation abillty (%) along the axis of ordinate wherein the ability is estimated to be 0 % in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100 % is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, diabetes mellitus of said animal is prevented or cured; and
       a method of treating diabetes mellitus of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the diabetes mellitus of said animal.