公开(公告)号：EP1700842A3

公开(公告)日：2010-02-24

申请号：EP06013052.3

申请日：2001-07-26

Applicant: Shire US Inc.

Inventor： Lang, Philip Charles ,  Spencer, Roxanne Paula ,  Yeh, Wen-Lung ,  Roth, Michael Joseph

IPC: C07C209/36 ,  C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C201/14

CPC classification number: C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C227/04 ,  C07C227/16 ,  C07C229/16 ,  C07C205/12 ,  C07C205/26 ,  C07C205/44

Abstract: Methods are provided for making certain 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from 2,3-dihalobenzaldehydes. A method is also provided for making the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-dihalobenzaldehydes and for reducing the glycine compounds using either SnCl 2 or a specially defined catalyst. A cyclization method to form the desired 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from the corresponding iminoquinazoline compounds is further provided. These methods are particularly suitable in the manufacture of Anagrelide base.

公开(公告)号：EP1700843A2

公开(公告)日：2006-09-13

申请号：EP06013053.1

申请日：2001-07-26

Applicant: Shire US Inc.

Inventor： Lang, Philip Charles ,  Spencer, Roxanne Paula ,  Yeh, Wen-Lung ,  Roth, Michael Jopseph

IPC: C07C209/36 ,  C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C201/14

CPC classification number: C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C227/04 ,  C07C227/16 ,  C07C229/16 ,  C07C205/12 ,  C07C205/26 ,  C07C205/44

Abstract: Methods are provided for making certain 6,7-dihalo-1,5-dihydroimidazo [2,1-b] quinazolin-2(3H)-ones from 2,3-dihalobenzaldehydes. A method is also provided for making the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-dihalobenzaldehydes and for reducing the glycine compounds using either SnCl 2 or a specially defined catalyst. A cyclization method to form the desired 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from the corresponding iminoquinazoline compounds is further provided. These methods are particularly suitable in the manufacture of Anagrelide base.

Abstract translation: 提供了从2,3-二卤代苯甲醛制备某些6,7-二卤代-1,5-二氢咪唑并[2,1-b]喹唑啉-2（3H） - 酮的方法。 还提供了从2,3-二卤代苯甲醛制备中间体N-（2,3-二卤代-6-硝基苄基）甘氨酸和使用SnCl2或特定催化剂还原甘氨酸化合物的方法。 进一步提供从相应的亚氨基喹唑啉化合物形成所需的6,7-二卤代-1,5-二氢咪唑并[2,1-b]喹唑啉-2（3H） - 酮的环化方法。 这些方法特别适用于制造阿那格雷碱。

公开(公告)号：EP0998440A1

公开(公告)日：2000-05-10

申请号：EP98934499.9

申请日：1998-07-14

Applicant: E.I. DU PONT DE NEMOURS AND COMPANY ,  ELF ATOCHEM S.A.

Inventor： CONTRACTOR, Rashmikant, Maganlal ,  ANDERSON, Mark, William ,  CAMPOS, Daniel ,  HECQUET, Gérard ,  KOTWICA, Roland ,  PHAM, Charlotte ,  SIMON, Michel

IPC: C07C45/28 ,  C07C47/22 ,  B01J8/38 ,  B01J23/31 ,  B01J23/92 ,  C07C201/14

CPC classification number: B01J23/94 ,  B01J8/0055 ,  B01J8/1863 ,  B01J8/26 ,  C07C45/28 ,  Y02P20/584 ,  C07C47/22

Abstract: An improved method for the selective vapor phase oxidation of propylene to acrolein in a recirculating solids reactor system using a bismuth molybdate multimetal oxide involving specific reactant concentrations (preferably 5 mol % to 30 md % propylene, 0 to 20 mol % oxygen, and the remainder inert gas), particle size (1 to 300 micrometers), temperature (250 to 450 °C) and gas (1 to 15 seconds) and solids (2 to 60 seconds) residence times. Such a process leads to improved selectivity and propylene conversion.

Abstract translation: 一种改进的方法，用于使用钼酸铋多金属氧化物在循环固体反应器系统中将丙烯选择性气相氧化成丙烯醛，所述钼酸铋多金属氧化物包含特定的反应物浓度（优选5mol％至30md％丙烯，0至20mol％氧气和余量 惰性气体），粒径（1至300微米），温度（250至450℃）和气体（1至15秒）和固体（2至60秒）的停留时间。 这种方法导致改进的选择性和丙烯转化率。

公开(公告)号：EP2491000A1

公开(公告)日：2012-08-29

申请号：EP10765718.1

申请日：2010-10-06

Applicant: ANGUS Chemical Company

Inventor： TRAUTH, Daniel, M. ,  GREEN, George, D. ,  SWEDO, Raymond, J.

IPC: C07C205/02 ,  C07C201/08 ,  C07C201/14

CPC classification number: C07C201/08 ,  Y02P20/582 ,  C07C205/02

Abstract: Provided is a process for making nitrated hydrocarbons by reacting aqueous nitric acid with a hydrocarbon feedstock and a carboxylic acid under specific reaction conditions.

公开(公告)号：EP1700841A3

公开(公告)日：2010-02-24

申请号：EP06013050.7

申请日：2001-07-26

Applicant: Shire US Inc.

Inventor： Lang, Philip Charles ,  Spencer, Roxanne Paula ,  Yeh, Wen-Lung ,  Roth, Michael Joseph

IPC: C07C201/08 ,  C07C201/12 ,  C07C201/14 ,  C07D487/04 ,  C07C209/36

CPC classification number: C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C227/04 ,  C07C227/16 ,  C07C229/16 ,  C07C205/12 ,  C07C205/26 ,  C07C205/44

Abstract: Methods are provided for making certain 6,7-dihalo-1,5-dihydroimidazo [2,1-b] quinazolin-2 (3H) -ones from 2,3-dihalobenzaldehydes. A method is also provided for making the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-dihalobenzaldehydes and for reducing the glycine compounds using either SnCl 2 or a specially defined catalyst. A cyclization method to form the desired 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from the corresponding iminoquinazoline compounds is further provided. These methods are particularly suitable in the manufacture of Anagrelide base.

公开(公告)号：EP2055689A1

公开(公告)日：2009-05-06

申请号：EP09000403.7

申请日：2004-05-17

Applicant: Sumitomo Chemical Company, Limited ,  Carreira, Erick M.

Inventor： Carreira, Erick, M.

IPC: C07B53/00 ,  C07C201/12 ,  C07C201/14 ,  C07C205/04 ,  C07C205/09 ,  C07C205/15 ,  C07C205/16 ,  C07C205/37 ,  C07C205/45 ,  C07C209/34 ,  C07C211/28 ,  C07C231/12 ,  C07C231/18 ,  C07D213/06 ,  C07D213/38 ,  C07D307/12 ,  C07D307/38 ,  C07D307/52 ,  C07D307/58 ,  C07D309/04 ,  C07D309/06 ,  C07D333/12 ,  C07D333/20

CPC classification number: C07B53/00 ,  C07B2200/07 ,  C07C201/12 ,  C07C231/18 ,  C07D213/38 ,  C07D307/12 ,  C07D307/52 ,  C07D309/04 ,  C07D333/20 ,  C07C233/13 ,  C07C233/66 ,  C07C205/04 ,  C07C205/09 ,  C07C205/15 ,  C07C205/16 ,  C07C205/32 ,  C07C205/45

Abstract: A method for producing an optically active nitro compound having two hydrogen atoms on its α-carbon atom and having β-asymmetric carbon atom which comprises making an α, β-unsaturated nitroolefin having a hydrogen atom on its α-carbon atom react with at least one organosilicon compound having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex and water.

Abstract translation: 一种在其± - 碳原子上具有2-不对称碳原子的具有2个氢原子的光学活性硝基化合物的方法，其包括在其± - 碳原子上制备具有氢原子的±，2不饱和的硝基烯烃至少与 一种在不对称铜配合物和水的存在下在分子中具有至少一个硅氢键的有机硅化合物。

公开(公告)号：EP1700841A2

公开(公告)日：2006-09-13

申请号：EP06013050.7

申请日：2001-07-26

Applicant: Shire US Inc.

Inventor： Lang, Philip Charles ,  Spencer, Roxanne Paula ,  Yeh, Wen-Lung ,  Roth, Michael Joseph

IPC: C07C201/08 ,  C07C201/12 ,  C07C201/14 ,  C07D487/04 ,  C07C209/36

CPC classification number: C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C227/04 ,  C07C227/16 ,  C07C229/16 ,  C07C205/12 ,  C07C205/26 ,  C07C205/44

Abstract: Methods are provided for making certain 6,7-dihalo-1,5-dihydroimidazo [2,1-b] quinazolin-2 (3H) -ones from 2,3-dihalobenzaldehydes. A method is also provided for making the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-dihalobenzaldehydes and for reducing the glycine compounds using either SnCl 2 or a specially defined catalyst. A cyclization method to form the desired 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from the corresponding iminoquinazoline compounds is further provided. These methods are particularly suitable in the manufacture of Anagrelide base.

Abstract translation: 提供了从2,3-二卤代苯甲醛制备某些6,7-二卤代-1,5-二氢咪唑并[2,1-b]喹唑啉-2（3H） - 酮的方法。 还提供了从2,3-二卤代苯甲醛制备中间体N-（2,3-二卤代-6-硝基苄基）甘氨酸和使用SnCl2或特定催化剂还原甘氨酸化合物的方法。 进一步提供从相应的亚氨基喹唑啉化合物形成所需的6,7-二卤代-1,5-二氢咪唑并[2,1-b]喹唑啉-2（3H） - 酮的环化方法。 这些方法特别适用于制造阿那格雷碱。

公开(公告)号：EP1700840A2

公开(公告)日：2006-09-13

申请号：EP06013049.9

申请日：2001-07-26

Applicant: Shire US Inc.

Inventor： Lang, Philip Charles ,  Spencer, Roxanne Paula ,  Yeh, Wen-Lung ,  Roth, Michael Joseph

IPC: C07C201/08 ,  C07C201/12 ,  C07C201/14 ,  C07D487/04 ,  C07C209/36

CPC classification number: C07D487/04 ,  C07C201/08 ,  C07C201/12 ,  C07C227/04 ,  C07C227/16 ,  C07C229/16 ,  C07C205/12 ,  C07C205/26 ,  C07C205/44

Abstract: Methods are provided for making certain 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from 2,3-dihalobenzaldehydes. A method is also provided for making the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-dihalobenzaldehydes and for reducing the glycine compounds using either SnCl 2 or a specially defined catalyst. A cyclization method to form the desired 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from the corresponding iminoquinazoline compounds is further provided. These methods are particularly suitable in the manufacture of Anagrelide base.

Abstract translation: 提供了从2,3-二卤代苯甲醛制备某些6,7-二卤代-1,5-二氢咪唑并[2,1-b]喹唑啉-2（3H） - 酮的方法。 还提供了从2,3-二卤代苯甲醛制备中间体N-（2,3-二卤代-6-硝基苄基）甘氨酸和使用SnCl2或特定催化剂还原甘氨酸化合物的方法。 进一步提供从相应的亚氨基喹唑啉化合物形成所需的6,7-二卤代-1,5-二氢咪唑并[2,1-b]喹唑啉-2（3H） - 酮的环化方法。 这些方法特别适用于制造阿那格雷碱。

公开(公告)号：EP0402485A1

公开(公告)日：1990-12-19

申请号：EP90901095.1

申请日：1989-12-22

Applicant: ANDRIEVSKY, Alexandr Mikhailovich ,  GORELIK, Mikhail Viktorovich ,  AVIDON, Sergei Viktorovich ,  GORDIEVSKAYA, Evgenia Vasilievna ,  ALTMAN, Elena Shulimovna ,  VOROZHTSOV, Georgy Nikolaevich ,  DJUMAEV, Kirill Mikhailovich

Inventor： ANDRIEVSKY, Alexandr Mikhailovich ,  GORELIK, Mikhail Viktorovich ,  AVIDON, Sergei Viktorovich ,  GORDIEVSKAYA, Evgenia Vasilievna ,  ALTMAN, Elena Shulimovna ,  VOROZHTSOV, Georgy Nikolaevich ,  DJUMAEV, Kirill Mikhailovich

IPC: C07C205/12 ,  C07C201/08 ,  C07C201/06 ,  C07C201/14 ,  C07B39/00 ,  C07B43/02

CPC classification number: C07C201/14 ,  C07C205/12

Abstract: Die Herstellung von 2-Brom-4,6-dinitrochlorbenzol wird aus Chlorbenzol, das vorher mit einem Gemisch aus Schwefel- und Salpetersäure behandelt wird, oder aus individuellen o-, p-Nitrochlorbenzolen, oder aus einem eutektischen Gemisch von o-, p-, m-Nitrochlorbenzolen vorgenommen, indem man beliebige der genannten Stoffe bei einer Temperatur von 20 bis 120° C mit Brom oder mit Alkalimetallbromid, mit Salpetersäure oder mit Alkalimetallnitrat und mit Schwefelsäure oder mit Oleum bei folgenden Molverhältnissen der Reagenzien behandelt: Ausgangsstoff: Brom oder Alkalimetallbromid: Salpetersäure oder Alkalimetallnitrat: Schwefelsäure oder Oleum gleich 1,0:0,5-1,5 oder 1,0-3,0:2,0-4,0 oder 2,5-5,0:6,0-70,0.

Abstract translation: 氯苯的2-溴-4,6-二硝基氯苯，这是预先用硫酸和硝酸的混合物处理的制备中，或从个人邻 - ，对 - 硝基氯苯，或低共熔混合物邻，对 ，间硝基氯苯在20的温度下上述至120℃下用溴或与碱金属溴化物的物质的任何处理制成，用硝酸或与碱金属硝酸盐和硫酸或在试剂的以下摩尔比的发烟硫酸：起始原料：溴或碱金属溴化物 ：硝酸或碱金属硝酸盐：硫酸或发烟硫酸是等于1.0：0.5-1.5，或1.0-3.0：2.0-4.0或2.5-5.0：6.0至70 第0

公开(公告)号：EP4324558A1

公开(公告)日：2024-02-21

申请号：EP22787881.6

申请日：2022-03-02

Applicant: Organo Corporation

Inventor： NAKAMURA, Shinji ,  SAJIKI, Hironao ,  YAMADA, Tsuyoshi ,  PARK, Kwihwan ,  YAMADA, Yutaro

IPC: B01J35/04 ,  B01J35/10 ,  C07B37/04 ,  C07C22/08 ,  C07C201/14 ,  C07C205/06 ,  C07C253/30 ,  C07C255/50 ,  C07C17/26 ,  C07B61/00 ,  C08J5/20 ,  B01J41/05 ,  B01J41/14 ,  B01J47/12 ,  B01J31/08

Abstract: The purpose of the present invention is to provide: an ion exchanger which shows small shrinkage upon the contact with an organic solvent in a water-wetted state; and a method for producing the ion exchanger. Provided is an ion exchanger which is composed of a polymer chain represented by general formula (1)

(wherein R 1 represents an alkyl group of 4 to 22 carbon atoms which may be substituted; or a benzyl group which may be substituted with an alkyl group of 1 to 6 carbon atoms which may be substituted, a halogen atom, an alkoxy group of 1 to 6 carbon atoms which may be substituted, an amino group which may be substituted, a cyano group, or a nitro group; R 2 and R 3 each independently represent an alkyl group of 1 to 4 carbon atoms; L represents a linker site; and "Polymer" represents a polymer chain).