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公开(公告)号：EP1940844B1
公开(公告)日：2009-09-30
申请号：EP06826446.4
申请日：2006-10-20
发明人： NAGLE, Advait , GRAY, Nathanael S.
IPC分类号： C07D487/02 , A61K31/519 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-Abl, Aurora- A, AxI, BMX, CHK2, c-RAF, cSRC, Fes, FGFR3, Flt3, IKKα, IR, JNK2α2, Lck, Met, MKK6, MST2, p70S6K, PDGFRα, PKA, PKD2, ROCK-II, Ros, Rskl, SAPK2α, SAPK2β, SAPK3 SAPK4, Syk, Tie2 and TrkB kinases.
摘要翻译： 本发明提供了一类新化合物，包含此类化合物的药物组合物以及使用此类化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症，特别是涉及AbI，Bcr-Abl异常活化的疾病或病症的方法 ，Aurora-A，AxI，BMX，CHK2，c-RAF，cSRC，Fes，FGFR3，Flt3，IKKα，IR，JNK2α2，Lck，Met，MKK6，MST2，p70S6K，PDGFRα，PKA，PKD2，ROCK-II， ，Rsk1，SAPK2α，SAPK2β，SAPK3 SAPK4，Syk，Tie2和TrkB激酶。
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192.发明公开NOVEL ZWITTERIONIC FLUORESCENT DYES FOR LABELING IN PROTEOMIC AND OTHER BIOLOGICAL ANALYSES 审中-公开NEW两性离子荧光探针用于标记AT PROTEO搅拌等生物分析
公开(公告)号：EP1543007A4
公开(公告)日：2009-07-01
申请号：EP03765680
申请日：2003-07-18
申请人： UNIV MONTANA STATE
发明人： DRATZ EDWARD A , GRIECO PAUL A
IPC分类号： C07D487/02 , C07F5/02 , G01N33/533 , G01N33/58
CPC分类号： C07F5/022 , G01N33/533 , G01N33/582
摘要： The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, e.g. between pH 3 and 12. These dye molecules find utility in a variety of applications, including use in the field of proteomics.
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公开(公告)号：EP1696912A4
公开(公告)日：2009-06-03
申请号：EP04821468
申请日：2004-10-01
发明人： HAYS DAVID S , DANIELSON MICHAEL E , GERSTER JOHN F , NIWAS SHRI , PRINCE RYAN B , KSHIRSAGAR TUSHAR A , HEPPNER PHILIP D , MOSER WILLIAM H , MOSEMAN JOAN T , RADMER MATTHEW R , KAVANAGH MAUREEN A , STRONG SARAH A , BONK JASON D
IPC分类号： C07D471/04 , A61K31/437 , C07D471/14 , C07D487/02 , C07D487/12
CPC分类号： C07D471/04 , C07D401/14 , C07D471/14 , C07D495/14
摘要： Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.
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公开(公告)号：EP1658290A4
公开(公告)日：2009-04-15
申请号：EP04816834
申请日：2004-08-27
申请人： IRM LLC
发明人： DING QIANG , GRAY NATHANAEL SCHIANDER , LI BING , LIU YI , UNO TETSUO
IPC分类号： C07D471/04 , A61K20060101 , A61K31/4355 , A61K31/4745 , A61K31/519 , A61K31/675 , A61P35/00 , C07D471/02 , C07D487/02 , C07D487/04
CPC分类号： C07D487/04
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195.发明公开
公开(公告)号：EP2032576A1
公开(公告)日：2009-03-11
申请号：EP07725571.9
申请日：2007-05-25
IPC分类号： C07D487/02 , C07D487/04
CPC分类号： C07D487/02 , C07D487/04 , Y02P20/55
摘要： A process is provided for the N-demethylation of certain morphinans by reaction with α-chloroethyl chloroformate followed by hydrolysis of the resulting intermediate.
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公开(公告)号：EP2015752A2
公开(公告)日：2009-01-21
申请号：EP07873406.8
申请日：2007-04-04
IPC分类号： A61K31/519 , A61P35/00 , A61P35/02 , C07D487/02 , C12N9/99
CPC分类号： C07D487/04
摘要： The present invention provides methods for identifying PI3-Kinase antagonists and antagonists identified by said method.
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197.发明公开
公开(公告)号：EP1997809A8
公开(公告)日：2009-01-14
申请号：EP08164856
申请日：2004-02-25
申请人： ARRAY BIOPHARMA INC
发明人： MUNSON MARK , MARESKA DAVID A , KIM YOUNGBOO , GRONEBERG ROBERT , RIZZI JAMES , RODRIGUEZ MARTHA , KIM GANGHYEOK , VIGERS GUY , RAO CHANG , BALACHARI DEVAN , HARVEY DARREN
IPC分类号： C07D231/56 , A61K20060101 , A61K31/416 , A61K31/4162 , A61K31/42 , A61K31/4745 , A61K31/503 , A61K31/675 , C07D20060101 , C07D261/20 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
CPC分类号： C07D401/14 , C07D231/56 , C07D261/20 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
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198.发明公开BENZOIMIDAZOLYL-PARAZINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES 审中-公开苯并咪唑，PARAZIN化合物用来对付炎症和免疫特殊疾病
公开(公告)号：EP2001476A2
公开(公告)日：2008-12-17
申请号：EP07753877.5
申请日：2007-03-20
发明人： CHEN, Shoujun , JIANG, Jun , ZHANG, Junyi , XIE, Yu
IPC分类号： A61K31/497 , A61K31/53 , C07D473/02 , C07D403/02 , C07D487/02
CPC分类号： C07D413/14 , C07D401/14 , C07D403/04 , C07D417/14
摘要： The invention relates to compounds of structural formula (I) or (III) or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein ring A, X1, X2, X3, X5, R1, R4, Y, Z, L, m and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
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公开(公告)号：EP1968581A2
公开(公告)日：2008-09-17
申请号：EP06850957.9
申请日：2006-12-14
申请人： Genentech, Inc.
IPC分类号： A61K31/4162 , C07D487/02
CPC分类号： C07D497/16
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula (I): I wherein X, Y, Z, R1, R2, R3, Ra, Rb, and n are as described herein.
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公开(公告)号：EP1608631A4
公开(公告)日：2008-08-20
申请号：EP04758392
申请日：2004-03-26
申请人： SCIOS INC
IPC分类号： C07D239/70 , A61K31/517 , A61K31/519 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/04 , C07D471/04 , C07D487/02 , C07D487/04 , C07D491/02 , C07D491/04 , C07D491/048 , C07D493/04 , C07D495/04 , C07D498/02 , C07D498/04
CPC分类号： C07D487/04 , A61K31/517 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D498/04
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