利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

45 条记录 (耗时 0.024 秒)

    Decreasing potential iatrogenic risks associated with influenza vaccines
    21.
    发明公开
    Decreasing potential iatrogenic risks associated with influenza vaccines 有权
    Verminderung von potentiellen iatrogenen Risiken in Verbindung mit Influenza Impfstoffen

    公开(公告)号：EP2236155A1

    公开(公告)日：2010-10-06

    申请号：EP10075310.2

    申请日：2005-09-09

    申请人： Novartis Vaccines and Diagnostics GmbH

    发明人： Gregersen, Jens Peter

    IPC分类号： A61K39/145 ,  C12Q1/70

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  C12N2760/16034 ,  C12N2760/16051 ,  C12N2760/16134 ,  C12N2760/16234 ,  C12Q1/70 ,  C12Q1/701 ,  G01N33/56983 ,  G01N2333/11 ,  Y02A50/467

    摘要： Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modem techniques grow the virus in mammalian cell culture e . g . on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus culture can increase the risk that pathogens other than influenza virus may grow in the cell lines and have identified specific contamination risks. Suitable tests can thus be performed during manufacture in order to ensure safety and avoid iatrogenic infections.

    摘要翻译： 用于制备人类疫苗的流感病毒传统上已经在含胚的鸡蛋上生长，尽管更多的现代技术在哺乳动物细胞培养物中生长病毒e。 G 。 在Vero，MDCK或PER.C6细胞系上。 发明人认识到，用于流感病毒培养的条件可增加除流感病毒以外的病原体可能在细胞系中生长并识别特定污染风险的风险。 因此，在制造过程中可以进行合适的测试，以确保安全性并避免医源性感染。

    FERMENTER SYSTEM FOR BIOTECHNICAL PROCESSES
    23.
    发明公开
    FERMENTER SYSTEM FOR BIOTECHNICAL PROCESSES 审中-公开
    生物技术过程的FERMENTER系统

    公开(公告)号：EP1885838A2

    公开(公告)日：2008-02-13

    申请号：EP06753895.9

    申请日：2006-05-26

    申请人： Novartis Vaccines and Diagnostics GmbH & Co. KG

    发明人： MÜLLER, Gunther ,  VORLOP, Jürgen ,  ZIMMERMANN, Achim

    IPC分类号： C12M1/04

    CPC分类号： C12M23/22 ,  C12M23/58 ,  C12M27/02 ,  C12M41/22

    摘要： A fermenter for use in biotechnical processes in particular for culturing cells is disclosed. The object, to provide a fermenter vessel (1) the inner volume of which can be optically monitored and which fermenter vessel can also be efficiently sterilized is achieved by a fermenter vessel (1) having an outside wall (2) enclosing a vessel volume with a view port (7) being provided in the outside wall (2) for inspecting processes within the vessel volume, the view port (7) having a transparent member (8) wherein the transparent member (8) is provided with a heating device.

    摘要翻译： 公开了用于特别用于培养细胞的生物技术过程的发酵罐。 本发明的目的是提供一种发酵罐容器（1），该发酵罐容器（1）的内部容积可以被光学监控，并且该发酵罐容器也可以被有效地消毒，该发酵罐容器（1）具有包围容器容积的外壁（2） 一个观察口（7）设置在外壁（2）中，用于检查容器体积内的过程，观察口（7）具有透明构件（8），其中透明构件（8）设置有加热装置。

    Cell-derived viral vaccines with low levels of residual cell DNA
    30.
    发明公开
    Cell-derived viral vaccines with low levels of residual cell DNA 无效
    VON ZELLEN STAMMENDE VIRALE IMPFSTOFFE MIT GERINGEN MENGEN REST-ZELL-DNA

    公开(公告)号：EP2301572A1

    公开(公告)日：2011-03-30

    申请号：EP10075529.7

    申请日：2006-11-01

    申请人： Novartis Vaccines and Diagnostics GmbH

    发明人： Kost, Holger ,  Gregersen, Jens-Peter

    IPC分类号： A61K39/12 ,  A61K39/145

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234

    摘要： The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as β-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.

    摘要翻译： 本发明涉及用于治疗或预防病毒感染的疫苗产品。 还提供了减少与细胞培养疫苗的制备相关的污染物的方法。 残留的功能细胞培养物DNA通过用DNA烷基化剂如β-丙内酯（BPL）处理而降解，由此提供一种疫苗，其包含衍生自在细胞培养物上繁殖的病毒的免疫原性蛋白质，基本上不含残留的功能性细胞培养物DNA。