公开(公告)号：EP1319009A1

公开(公告)日：2003-06-18

申请号：EP01967326.8

申请日：2001-09-10

申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

发明人： KREMMINGER, Peter

IPC分类号： C07D501/06

CPC分类号： C07D501/00

摘要： Cefuroxime in the form of a salt with n-butylamine; and its use for the production of cefuroxime axetil or for the production of the sodium salt of cefuroxime.

公开(公告)号：EP1314527A1

公开(公告)日：2003-05-28

申请号：EP02025537.8

申请日：2002-11-13

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： Heinrich, Axel ,  Seiferling, Bernhard ,  Haberstroh, Klaus

IPC分类号： B29C35/08 ,  B29D11/00

CPC分类号： B29D11/00134 ,  B29C35/0888 ,  B29C2035/0827 ,  B29L2011/0041 ,  B29L2031/752

摘要： A method and an apparatus are proposed for producing mouldings, in particular ophthalmic lenses, such as contact lenses for example, in which a starting material located in a mould (100, 110; 100a, 110a) is polymerized and/or crosslinked by means of exposure to light, in particular by exposure to UV light, so that a demouldable moulding is produced. The measurement of the intensity (I) of the light takes place during the production of the mouldings.

摘要翻译： 提出了用于生产模制品的方法和装置，特别是眼用透镜，例如隐形眼镜，其中位于模具（100,110; 100a，110a）中的起始材料通过以下方式聚合和/或交联： 曝光，特别是通过暴露于紫外光，从而产生可脱模的模制品。 光的强度（I）的测量在模制品生产期间进行。

公开(公告)号：EP1307778A2

公开(公告)日：2003-05-07

申请号：EP01953169.8

申请日：2001-06-11

申请人： Wesley Jessen Corporation

发明人： OCAMPO, Gerardo, J. ,  QUINN, Michael, H.

IPC分类号： G02C7/04

CPC分类号： B29D11/00903 ,  B29D11/00317 ,  G02C7/046

摘要： A colored contact lens and a method of making same is provided. An image of an eye is recorded, optionally enhanced, separated into color pattern components, optionally enhanced, then each color pattern component printed on a contact lens, directly or indirectly. The end result is a natural looking contact that enhances the natural iris color or changes the apparent color of the natural iris.

公开(公告)号：EP1305282A1

公开(公告)日：2003-05-02

申请号：EP01954024.4

申请日：2001-07-09

申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

发明人： ASCHER, Gerd ,  BERNER, Heinz

IPC分类号： C07C323/52 ,  A61K31/10 ,  A61P31/04

CPC分类号： C07C323/52 ,  A61K31/215 ,  C07C2601/14 ,  C07C2603/99

摘要： A compound selected from 14-O-[(Cycloalkyl-sulfanyl)acetyl]mutilins; 14-O-[Cycloalkyl-alkyl-sulfanyl)acetyl] mutilins; 14-O-[(Cycloalkoxy)acetyl] mutilins; or 14-O[(Cycloalkyl-alkoxy)acetyl] mutilins and its use as a pharmaceutical.

摘要翻译： 选自14-O - [（环烷基 - 硫烷基）乙酰基] mutilins的化合物; 14-O - [（环烷基 - 烷基 - 硫烷基）乙酰基] mutilins; 14-O - [（环烷氧基）乙酰基] mutilins; 和14-O - [（环烷基 - 烷氧基）乙酰基] mutilins及其作为药物的用途。

公开(公告)号：EP1303489A2

公开(公告)日：2003-04-23

申请号：EP01950991.8

申请日：2001-07-10

申请人： GENEVA PHARMACEUTICALS, INC.

发明人： RAY, Anup, Kumar ,  PATEL, Hiren, Kumar, V. ,  MERAI, Shilpa, V. ,  PATEL, Mahendra, R.

IPC分类号： C07D211/56 ,  C07D213/74

CPC分类号： C07D213/74 ,  C07C45/46 ,  C07C45/63 ,  C07C49/80 ,  C07C49/813 ,  C07C49/84 ,  C07C67/00 ,  C07C67/343 ,  C07C231/10 ,  C07D211/26 ,  C07D295/182 ,  C07C69/92 ,  C07C69/738 ,  C07C235/60

摘要： This disclosure relates to the use of α,α-dibromo-α-chloroacetophenone compounds as intermediates for the preparation of aromatic carbonyl compounds, especially aromatic amides. The compound 2,5-bis(2,2,2-trifluoroethoxy)-α,α-dibromo-α-chloro-acetophenone is especially useful as an intermediate for the preparation of flecainide, a known pharmaceutical.

公开(公告)号：EP1300408A1

公开(公告)日：2003-04-09

申请号：EP03000220.8

申请日：1998-04-01

申请人： BIOCHEMIE Gesellschaft m.b.H.

发明人： Ascher, Gerd ,  Wieser, Josef ,  Schranz, Michael ,  Ludescher, Johannes ,  Hildebrandt, Johannes

IPC分类号： C07D501/38 ,  C07D295/20 ,  A61K31/546 ,  A61P31/04

CPC分类号： C07D295/215 ,  C07D501/00

摘要： A compound of formula
wherein W, V, R 1 , R 5 R 2 , R 3 and R 4 have various meanings, a process for their production and their use as a pharmaceutical.

摘要翻译： 其中W，V，R1，R5R2，R3和R4具有各种含义的式化合物，其制备方法及其作为药物的用途。

公开(公告)号：EP1292598A1

公开(公告)日：2003-03-19

申请号：EP01943455.4

申请日：2001-05-28

申请人： BIOCHEMIE Gesellschaft m.b.H.

发明人： BILKE, Hans, Werner ,  DAEMON, Otto ,  SCHWARZ, Franz, Xaver

IPC分类号： C07D499/00 ,  A61K31/43

CPC分类号： C07D499/00 ,  A61K9/2095 ,  A61K31/43

摘要： Process for drying amoxicillin (compositions), characterised in that a gas, which is inert towards amoxicillin (compositions) and having a relative humidity content which is greater than zero is used for drying.

公开(公告)号：EP1280929A2

公开(公告)日：2003-02-05

申请号：EP01973780.8

申请日：2001-04-30

申请人： Novartis AG ,  The Scripps Research Institute ,  Nemerow, Glen R. ,  Von Seggern, Daniel J. ,  Friedlander, Marty

发明人： NEMEROW, Glen R. ,  VON SEGGERN, Daniel J. ,  FRIEDLANDER, Marty

IPC分类号： C12N15/861 ,  A61K48/00 ,  A61P27/02

CPC分类号： C12N7/00 ,  A61K48/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10352 ,  C12N2810/6018

摘要： Adenovirus vector-based gene therapy methods for treating ocular disorders are provided. Adenovirus vectors for therapy of ocular diseases and methods of treatment using the vectors are provided. Compositions, kits, and methods of preparation and use of the vectors for gene therapy are provided.

公开(公告)号：EP1280822A2

公开(公告)日：2003-02-05

申请号：EP01929598.9

申请日：2001-04-24

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H. ,  The Scripps Research Institute

发明人： BALICKI, Danuta ,  BEUTLER, Ernest

IPC分类号： C07K14/47 ,  A61K48/00 ,  C12N15/87

CPC分类号： C07K14/4702

摘要： The present invention provides a novel gene delivery system in which a gene delivery facilitating peptide, generally derived from Histone H2A, is complexed with a nucleic acid for efficient and stable delivery of the nucleic acid into a cell, ultimately to the nucleus. Such peptide-mediated gene delivery is based on the principal that unneutralized positive charges on the histone are bound electrostatically both by the negatively charged phosphate backbone of DNA and that nuclear targeting signals in histones improve trafficking of the DNA to the nucleus for transcription.

公开(公告)号：EP1276711A2

公开(公告)日：2003-01-22

申请号：EP01931614.0

申请日：2001-04-17

申请人： Novartis AG

发明人： RAY, Anup Kumar ,  PATEL, Hiren Kumar V. ,  PATEL, Mahendra, R.

IPC分类号： C07C231/14 ,  C07C237/08 ,  C07C247/10

CPC分类号： C07C231/14 ,  C07C237/08 ,  C07C247/10

摘要： Midodrine hydrochloride, ± 1-(2',5'-dimethoxyphenyl)-2-glycineamido-ethanol-(1)- HCI, is prepared from a novel intermediate, 1-(2',5'-dimethoxyphenyl)-2-azidoethanone.