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    Iminosugar glycoconjugates
    21.
    发明公开
    Iminosugar glycoconjugates 审中-公开
    Iminozucker-Glykokonjugate

    公开(公告)号：EP1903034A1

    公开(公告)日：2008-03-26

    申请号：EP06019545.0

    申请日：2006-09-19

    申请人： Technische Universität Graz ,  Forschungsholding TU Graz GmbH

    发明人： Stütz, Arnold ,  Steiner, Andreas ,  Wrodnigg, Tanja

    IPC分类号： C07D211/00 ,  C07H17/02

    CPC分类号： C07K9/005 ,  C07D211/44 ,  C07K5/06086 ,  C07K5/0823 ,  Y02P20/55

    摘要： The iminosugar conjugates according to the invention are N-alkylated 1,5-dideoxy-1,5-iminohexitol or 1,5-dideoxy-1,5-iminopentitol derivatives. The iminosugar component can be, for example, D- gluco -, L- ido -, D- galacto -, D -manno -, 2-acetamido-2-deoxy-D- gluco - or xylo -configuration. The N-substituent is a protected L-α-aminoacid derivative, showing L-lysine-like structural features. The linkage between the carbohydrate and the peptide component is not via the usual glycosidic position, but shows structural features of a very stable tertiary amine. Thus the linkage is very stable. These new compounds are synthesised by using catalytic intramolecular reductive amination of dicarbonyl sugars with partially protected amino acids. The process of intramolecular reductive amination itself is carried out using Pearlman's catalyst (Pd(OH) 2 /C) and H 2 at ambient pressure and room temperature.
    The resulting accessible class of iminosugar conjugate compounds is represented by the general structure shown in Figure 4(c). The alkyl chain length parameter n can be freely chosen from n=0 upwards. Preferably n is between 0 and 10, and more preferably n is 2, 3, or 4. Residue R 1 can be chosen from H, OH, or NHAc, with Ac being Acetyl. R 2 can be H, OH, or NHAc. R 3 , R 4 , R 5 , R 6 can be H or OH. R 7 and R 8 can be H, CH2OH CH3, COQH, or COOR with R being Alkyl or Aryl. R 9 and R 10 can be chosen from H, NH 2 , NHR, with R being a protective group, an amino acid, a peptide, or a protein. R 11 can be OH, O-Alkyl, O-Aryl, NH 2 , N-Alkyl, N-Aryl, amino acid or peptide, connected via an amide bond.

    摘要翻译： 根据本发明的亚氨基糖偶联物是N-烷基化的1,5-二脱氧-1,5-亚氨基己糖醇或1,5-二脱氧-1,5-亚氨基二醇衍生物。 亚氨基缩寡核苷酸组分可以是例如D-葡萄糖，L-己糖，D-半乳糖，D-甘露醇，2-乙酰氨基-2-脱氧-D-葡萄糖或木糖结构。 N-取代基是受保护的L-±氨基酸衍生物，显示L-赖氨酸样结构特征。 碳水化合物和肽组分之间的连接不是通过通常的糖苷位置，而是显示非常稳定的叔胺的结构特征。 因此联动非常稳定。 这些新化合物通过使用具有部分保护的氨基酸的二羰基糖的催化分子内还原胺化来合成。 分子内还原胺化反应的过程本身使用Pearlman's催化剂（Pd（OH）2 / C）和H 2在环境压力和室温下进行。 得到的可接近类别的亚氨基糖偶联化合物由图4（c）所示的一般结构表示。 烷基链长度参数n可以从n = 0向上自由选择。 n优选为0至10，更优选n为2,3或4.残基R 1可以选自H，OH或NHAc，Ac为乙酰基。 R 2可以是H，OH或NHAc。 R 3，R 4，R 5，R 6可以是H或OH。 R 7和R 8可以是H，CH 2 OH CH 3，COQH或COOR，其中R是烷基或芳基。 R 9和R 10可以选自H，NH 2，NHR，其中R为保护基，氨基酸，肽或蛋白质。 R 11可以是通过酰胺键连接的OH，O-烷基，O-芳基，NH 2，N-烷基，N-芳基，氨基酸或肽。

    VERFAHREN UND VORRICHTUNG ZUM ERMITTELN DER FÖRDERPARAMETER EINES PARTIKEL FÜHRENDEN, DURCH EINE LEITUNG STRÖMENDEN FLUIDUMS
    26.
    发明公开
    VERFAHREN UND VORRICHTUNG ZUM ERMITTELN DER FÖRDERPARAMETER EINES PARTIKEL FÜHRENDEN, DURCH EINE LEITUNG STRÖMENDEN FLUIDUMS 审中-公开
    方法和一种用于确定粒子党的领导融资参数由管道中流动的流体

    公开(公告)号：EP1957944A1

    公开(公告)日：2008-08-20

    申请号：EP06804342.1

    申请日：2006-10-10

    申请人： Technische Universität Graz ,  Forschungsholding TU Graz GmbH

    发明人： FUCHS, Anton ,  ZANGL, Hubert

    IPC分类号： G01F1/56 ,  G01F1/704 ,  G01F1/74

    CPC分类号： G01F1/74 ,  G01F1/56 ,  G01F1/704

    摘要： The invention relates to a method and a device for determining the transport parameters of a particle transporting fluid flowing in a line, comprising an electrode arrangement with at least two electrodes, wherein the coupled capacitance between at least two electrodes arranged around the circumferential region of the line is measured and at least the flow speed of recorded particles is determined from the measured values, said measured values are subjected to a fast Fourier transform and a selected number n of obtained frequency components are summated to give a particle speed value. A device for determining the transport parameter of a particle-transporting fluid flowing in a line (LEI) comprises an electrode arrangement arranged in the circumferential region of the line with at least two electrodes (E1 ... E8; E1a, E1b ... E8a, E8b/ Ea, Eb, Eo, Eu), a measuring device (CME) for the real-time measurement of the coupled capacitance between the at least two electrodes and an analytical unit (AWE), to which the measured values from the measuring device are supplied. The analytical unit (AWE) subjects the measured values to a fast Fourier transform and a selected number n of the frequency components obtained are subjected to a summation to give a particle speed or density value.

    VERFAHREN UND VORRICHTUNG ZUM BESTIMMEN VON PARAMETERN EINER FLUKTUATIONEN AUFWEISENDEN STRÖMUNG
    27.
    发明公开
    VERFAHREN UND VORRICHTUNG ZUM BESTIMMEN VON PARAMETERN EINER FLUKTUATIONEN AUFWEISENDEN STRÖMUNG 审中-公开
    方法和设备，用来确定涨落具有流动性的物性参数

    公开(公告)号：EP1716395A2

    公开(公告)日：2006-11-02

    申请号：EP05706185.5

    申请日：2005-02-10

    申请人： Forschungsholding TU Graz GmbH

    发明人： ZANGL, Hubert ,  FUCHS, Anton

    IPC分类号： G01F1/712 ,  G01P5/22 ,  G01P3/80

    CPC分类号： G01F1/64 ,  G01F1/712 ,  G01F1/74 ,  G01P5/08 ,  G01P5/22

    摘要： The invention relates to a method and a device for determining the parameters of a fluctuating flow of a fluid in a pipe, wherein at least three electrodes (S1, E, S2) that are placed at a distance from one another in the direction of flow are provided in the periphery of the flow, wherein alternating voltage signals (ss) are fed to a first upstream transmission electrode arrangement (S1) and to a second downstream transmission electrode arrangement (S2) and the receiving signals (se) generated by the displacement current are detected in a receiving electrode arrangement (E) located between the transmission electrodes and subjected to a time-discrete cross-correlation. The throughput times of the fluctuations detected by the electrodes are determined on the basis of the results.