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    PROCESS FOR PRODUCING MATURATION BONE MORPHOGENETIC PROTEIN
    22.
    发明公开
    PROCESS FOR PRODUCING MATURATION BONE MORPHOGENETIC PROTEIN 失效
    用于生产骨衰老特异性蛋白质形态

    公开(公告)号：EP0915168A4

    公开(公告)日：1999-11-17

    申请号：EP97919717

    申请日：1997-04-28

    申请人： HOECHST MARION ROUSSEL LTD

    发明人： TAKAHASHI MIKIKO ,  MAKISHIMA F ,  KIMURA MICHIO

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/22 ,  A61P43/00 ,  C07K14/495 ,  C07K14/51 ,  C07K14/52 ,  C12N9/64 ,  C12P21/02 ,  C12P21/06 ,  C12R1/91 ,  C12N15/12

    CPC分类号： C07K14/51 ,  A61K38/00

    摘要： A process for producing a maturation bone morphogenetic protein by the action of a processing enzyme on a bone morphogenetic protein precursor, which comprises either introducing an expression vector of a bone morphogenetic protein precursor and an expression vector of a processing enzyme into an aminol cell strain, culturing the resultant strain to yield a maturation bone morphogenetic protein, and separating the same from the culture, or alternatively adding a solution of a processing enzyme to a solution of a bone morphogenetic protein precursor and incubating the obtained solution mixture. A suitable process comprises introducing an expression vector of a human MP52 precursor and an expression vector of a secretory furin variant into an established animal cell strain, culturing the resultant strain to yield a maturation bone morphogenetic protein, and separating the same from the culture.

    CARTILAGE/BONE INDUCING MATERIALS FOR REPARATION
    24.
    发明公开
    CARTILAGE/BONE INDUCING MATERIALS FOR REPARATION 失效
    Knorpel und Knochen bildendes材料zurGewebsrückgewinnung

    公开(公告)号：EP0884052A1

    公开(公告)日：1998-12-16

    申请号：EP96938460.1

    申请日：1996-11-14

    申请人： Hoechst Marion Roussel, Ltd.

    发明人： SHIMURA, Takesada Hoechst Marion Russel Ltd. ,  Toriyama,Satsuki Hoechst Marion Russel Ltd.

    IPC分类号： A61K38/18 ,  A61K47/32 ,  A61F2/28 ,  A61B17/56 ,  A61M37/00

    CPC分类号： A61L27/227 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61K38/1875 ,  C07K14/51

    摘要： A cartilage and bone morphogenetic repairing material which contains a bone morphogenetic protein and a polyoxyethylene-p-olyoxypropylene glycol. In particular, it is preferable that a molecular weight of a polypropylene glycol, i.e., a component of said polyoxyethylene-polyoxypropylene glycol, being in the range of about 1,500-4,000 and a weight ratio of ethylene oxide being in the range of 40-80%/molecule, and a concentration of said polyoxyethylene-polyoxypropylene glycol in an aqueous solution being about 10-50%.
    It may be applied in a cartilage and bone morphogenetic method requiring no surgical operation and which comprises a bone morphogenetic protein and a carrier having a high bio-absorption, a good affinity to the bone morphogenetic protein and capable of temperature dependent gel-sol reversible transition. It is convenient to apply locally to the site of bone fracture or bone defect with efficient treatment effect.

    摘要翻译： 含有骨形态发生蛋白和聚氧乙烯 - 对羟基丙二醇的软骨和骨形态发生修复材料。 特别地，优选聚丙二醇的分子量，即所述聚氧乙烯 - 聚氧丙烯二醇的组分在约1,500-4,000范围内，环氧乙烷的重量比在40-80范围内 ％/分子，并且所述聚氧乙烯 - 聚氧丙烯二醇在水溶液中的浓度为约10-50％。 它可以应用于不需要手术操作的软骨和骨形态发生方法，其包括骨形态发生蛋白和具有高生物吸收性，对骨形态发生蛋白具有良好亲和力并能够进行温度依赖性凝胶 - 溶胶可逆转换的载体 。 方便将局部施用于骨折或骨缺损部位，有效治疗效果。